Abstract: Biguanide compounds of formula where R1 comprises a cubanyl-substituted alkyl and R2 comprises a substituted or unsubstituted alkyl, and their use in the treatment of cancers and viral infections are described.

Abstract: Systems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container.

Abstract: An apparatus includes a plurality of processor cores, a cache memory that includes a plurality of banks, and a power management circuit. The power management circuit is configured to maintain a power credit approach for the apparatus that includes tracking a total number of currently available power credits, and to store a plurality of threshold values. Each threshold value is associated with one or more of a plurality of throttling actions. In response to the total number of currently available power credits reaching a particular threshold value of the plurality of threshold values, the power management circuit performs the one or more throttling actions associated with the particular threshold value. The plurality of throttling actions includes selectively throttling one or more of the plurality of processor cores, and selectively throttling one or more of the plurality of banks in the cache memory.

Abstract: An apparatus includes a plurality of processor cores, a cache memory that includes a plurality of banks, and a power management circuit. The power management circuit is configured to maintain a power credit approach for the apparatus that includes tracking a total number of currently available power credits, and to store a plurality of threshold values. Each threshold value is associated with one or more of a plurality of throttling actions. In response to the total number of currently available power credits reaching a particular threshold value of the plurality of threshold values, the power management circuit performs the one or more throttling actions associated with the particular threshold value. The plurality of throttling actions includes selectively throttling one or more of the plurality of processor cores, and selectively throttling one or more of the plurality of banks in the cache memory.

Abstract: Nanopatterned devices are easily fabricated, over large surface areas when desired, by forming a multilayer article of deformable substrate, brittle layer, and coating layer, and deforming the multilayer film such that a plurality of cracks are formed therein. The cracks have different physicochemical properties than the non-cracked coating layer, and advantageously serve as attachment points for culturing microorganisms.

Abstract: Nanopatterned devices are easily fabricated, over large surface areas when desired, by forming a multilayer article of deformable substrate, brittle layer, and coating layer, and deforming the multilayer film such that a plurality of cracks are formed therein. The cracks have different physicochemical properties than the non-cracked coating layer, and advantageously serve as attachment points for culturing microorganisms.

Abstract: A technique for obtaining an intermediate set of frequency dependant features from a speech signal for use in speech processing and in obtaining estimates of speech pitch. The technique utilizes multiple tapers derived from Slepian sequences to obtain a product of the speech signal and the Slepian functions. Multiple tapered Fourier transforms are then obtained from the product, from which the set of frequency dependent features are calculated. In a preferred embodiment, a derivative of the cepstrum of the speech signal is used as an estimate of speech signal pitch. In another preferred embodiment, the F-spectrum is calculated from the product and the F-cepstrum is obtained therefrom by calculating the Fourier transform of the smoothed derivative of the log of the F-spectrum. The maximum of the F-cepstrum also provides a pitch estimation.

Abstract: A hair curling roller having an oval-shaped, elongated body with two rounded ends and a U-shaped clip attached to an annular pivotal housing embedded through one rounded end of the body. The opposite end of the U-shaped clip has an enlarged spherical tip adapted to slide over a groove which extends through the rounded end of the oval-shaped body. As the sperical tip slides over the groove, the clip is pulled towards the oval-shaped body, securing any hair wound around the roller. In an alternate embodiment the traverse cross-section of the body is circular in shape and the clip is rotatably secured to the body by a ball and socket.