Patents by Inventor Elizabeth J. Goldsmith

Elizabeth J. Goldsmith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR INHIBITION OF AUTOPHAGY
    Publication number: 20200000806
    Abstract: The present invention concerns compounds and their use to treat cell proliferative disorders including tumor growth and metastasis. Compounds of the present invention act as inhibitors of TAOK2 and modulators of autophagy, thereby functioning as anti-cancer or cancer-preventative therapeutic agents.
    Type: Application
    Filed: July 3, 2019
    Publication date: January 2, 2020
    Inventors: Elizabeth J. Goldsmith, Alexander T. Piala, Malia B. Potts
  • COMPOSITIONS AND METHODS FOR INHIBITION OF AUTOPHAGY
    Publication number: 20170340636
    Abstract: The present invention concerns compounds and their use to treat cell proliferative disorders including tumor growth and metastasis. Compounds of the present invention act as inhibitors of TAOK2 and modulators of autophagy, thereby functioning as anti-cancer or cancer-preventative therapeutic agents.
    Type: Application
    Filed: May 24, 2017
    Publication date: November 30, 2017
    Inventors: Elizabeth J. Goldsmith, Alexander T. Piala, Malia B. Potts
  • Chimerizing protein kinases for drug discovery
    Publication number: 20030032649
    Abstract: The present invention relates to chimeric protein kinase molecules and methods for designing inhibitors of protein kinases using the chimeric protein kinases of the present invention. The chimeric protein kinase of the present invention comprise inhibitor binding site residues of a non-crystallizable protein and non-inhibitor binding site residues of a crystallizable protein. The chimeric protein is preferably crystallizable and is useful for designing inhibitors for the non-crystallizable protein. In addition, the present invention is directed to a protein kinase inhibitor binding site which is outside the ATP binding site of the protein kinase and methods of use therefore.
    Type: Application
    Filed: July 31, 2001
    Publication date: February 13, 2003
    Inventors: Elizabeth J. Goldsmith, Akella Radha, Richard B. Gaynor
  • Pai-1 mutants
    Patent number: 5866413
    Abstract: The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: February 2, 1999
    Assignee: Board of Regents of the University of Texas System
    Inventors: Joseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething, Robert D. Gerard
  • U-PA mutants resistant to inhibition by their cognate inhibitors
    Patent number: 5728564
    Abstract: The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
    Type: Grant
    Filed: May 21, 1996
    Date of Patent: March 17, 1998
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Joseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething, Robert D. Gerard
  • Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors and genes encoding the same and serine protease inhibitor mutants and genes encoding the same
    Patent number: 5550042
    Abstract: The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: August 27, 1996
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Joseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething, Robert D. Gerard
  • Genes encoding serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
    Patent number: 5486602
    Abstract: The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: January 23, 1996
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Joseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething
  • Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
    Patent number: 5304482
    Abstract: The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: April 19, 1994
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Joseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething