Abstract: The present disclosure provides, inter alia, antibody-drug conjugates that are useful in treating various diseases such as cancer.

Abstract: A mixing system for a power washer includes an electrically actuated valve communicated with a supply of a working fluid, and having a valve head that is movable between open and closed positions to control the flow rate of the working fluid through an outlet of the valve. The outlet of the valve is communicated with a fluid passage of the power washer to enable flow of the working fluid into a primary fluid and discharge of a mixture of the primary fluid and working fluid from the power washer when the valve is open, and to provide a flow of primary fluid from the power washer when the valve is closed.

Abstract: The invention provides systems and methods for ergonomic dental instruments for dental professionals with small hands. In one embodiment, a dental instrument includes an elongated metal handle having a length in the range of about 3- 7/16 inches to about 3- 15/16 inches and a diameter in the range of about ¼ inches to about ¾ inches. A working end may be operably coupled to one or both ends of the handle via a sweated fit. The length and knurling of the elongated metal shaft and terminal shaft facilitate optimum performance for the user.