Abstract: The present disclosure provides a method of treating or preventing a disease or condition associated with fibrosis and/or diabetes in a subject in need thereof comprising subcutaneously administering to the subject one or more effective doses of a fibroblast growth factor 21 (FGF-21) polypeptide, e.g., FGF-21 conjugate, e.g., PEG-FGF-21.

Abstract: The disclosure relates to a method for depolymerizing lignin. The method includes reacting a lignin compound with a thiol compound to depolymerize the lignin compound and to form a depolymerized lignin product having a reduced molecular weight relative to the lignin compound prior to reacting. The method can further include forming an oxidized thiol reaction product between two thiol groups from one or more thiol compounds, and then reducing the oxidized thiol reaction product to re-form or regenerate the thiol compound for further lignin depolymerization.

Abstract: The disclosure relates to a method for depolymerizing lignin. The method includes reacting a lignin compound with a thiol compound to depolymerize the lignin compound and to form a depolymerized lignin product having a reduced molecular weight relative to the lignin compound prior to reacting. The method can further include forming an oxidized thiol reaction product between two thiol groups from one or more thiol compounds, and then reducing the oxidized thiol reaction product to re-form or regenerate the thiol compound for further lignin depolymerization.

Abstract: The present invention is a physiological measurement and stimulation device that can autonomously adapt its actuation output behavior based on acquired data in the form of biofeedback sensory measurements. When operating the invention, the user can place the device on the body at the intended area of operation, at which time the physiological measurements sensors can initiate data collection. Either prior to or following this time, the actuator can be activated and controlled manually and/or autonomously per a command signal generated by the control system. The operation of the present invention can be continued until the invention detects that a predetermined threshold has been reached. When the invention is used as a sexual stimulation device, the predetermined threshold can be physiological data corresponding to various stages of arousal or orgasm.

Abstract: The present invention is a physiological measurement and stimulation device that can autonomously adapt its actuation output behavior based on acquired data in the form of biofeedback sensory measurements. When operating the invention, the user can place the device on the body at the intended area of operation, at which time the physiological measurements sensors can initiate data collection. Either prior to or following this time, the actuator can be activated and controlled manually and/or autonomously per a command signal generated by the control system. The operation of the present invention can be continued until the invention detects that a predetermined threshold has been reached. When the invention is used as a sexual stimulation device, the predetermined threshold can be physiological data corresponding to various stages of arousal or orgasm.