Patents by Inventor Elizabeth Leadbetter

Elizabeth Leadbetter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nanoparticles for immune stimulation
    Patent number: 10881720
    Abstract: The invention relates, in part, to nanoparticles, methods for preparing nanoparticles and methods of administering nanoparticles for immune stimulation. An immune-stimulating nanoparticle of the invention may include, at least in part, a polymer substrate comprising a biodegradable polymer and may include at least one antigen and/or at least one adjuvant.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: January 5, 2021
    Assignees: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Elizabeth Leadbetter, Eyal Amiel, Emilie Vomhof-Dekrey, Robert Lindhardt, Amanda MacDonald, Jianjun Maio
  • NANOPARTICLES FOR IMMUNE STIMULATION
    Publication number: 20170165345
    Abstract: The invention relates, in part, to nanoparticles, methods for preparing nanoparticles and methods of administering nanoparticles for immune stimulation. An immune-stimulating nanoparticle of the invention may include, at least in part, a polymer substrate comprising a biodegradable polymer and may include at least one antigen and/or at least one adjuvant.
    Type: Application
    Filed: January 29, 2015
    Publication date: June 15, 2017
    Inventors: Elizabeth LEADBETTER, Eyal AMIEL, Emilie VOMHOF-DEKREY, Robert LINDHARDT, Amanda WEYERS, Jianjun MAIO
  • METHOD AND COMPOSITION FOR TREATING IMMUNE COMPLEX ASSOCIATED DISORDERS
    Publication number: 20100203053
    Abstract: The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g., cryoglobulinemia) in a subject having an ICAD or at risk for developing ICAD. The invention is based upon the surprising finding that chromatin-containing immune complexes activate autoreactive B cells and dendritic cells by a dual receptor engagement process which, in both cell types, involves a Toll-like receptor (TLR).
    Type: Application
    Filed: November 25, 2009
    Publication date: August 12, 2010
    Applicants: Trustees of Boston University, Yale University
    Inventors: Ann Marshak-Rothstein, Elizabeth A. Leadbetter, Ian R. Rifkin, Mark J. Shlomchik
  • Method and composition for treating immune complex associated disorders
    Patent number: 7709451
    Abstract: The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g., cryoglobulinemia) in a subject having an ICAD or at risk for developing ICAD. The invention is based upon the surprising finding that chromatin-containing immune complexes activate autoreactive B cells and dendritic cells by a dual receptor engagement process which, in both cell types, involves a Toll-like receptor (TLR).
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: May 4, 2010
    Assignees: Trustees of Boston University, Yale University
    Inventors: Ann Marshak-Rothstein, Elizabeth A. Leadbetter, Ian R. Rifkin, Mark J. Shlomchik
  • Conjugate vaccines for non-proteinaceous antigens
    Publication number: 20070231344
    Abstract: The present invention is directed to pharmaceutical compositions that can be used to immunize subjects using, for example, lipid, glycan, or nucleic acid antigens. These antigens are conjugated to a glycosphingolipid.
    Type: Application
    Filed: October 30, 2006
    Publication date: October 4, 2007
    Applicants: The Brigham and Women's Hospital, Inc., The University of Birmingham
    Inventors: Elizabeth Leadbetter, Michael Brenner, Gurdyal Besra
  • Method and composition for treating immune complex associated disorders
    Publication number: 20050106142
    Abstract: The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g., cryoglobulinemia) in a subject having an ICAD or at risk for developing ICAD. The invention is based upon the surprising finding that chromatin-containing immune complexes activate autoreactive B cells and dendritic cells by a dual receptor engagement process which, in both cell types, involves a Toll-like receptor (TLR).
    Type: Application
    Filed: September 9, 2002
    Publication date: May 19, 2005
    Inventors: Ann Marshak-Rothstein, Elizabeth Leadbetter, Ian Rifkin, Mark Shlomchik