Patents by Inventor Elizabeth M. Kudlacz

Elizabeth M. Kudlacz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating chronic obstructive pulmonary disease (COPD)
    Publication number: 20030232048
    Abstract: The present disclosure relates to methods of treating Chronic Obstructive Pulmonary Disease (COPD) and its various indications, particularly including chronic bronchitis, emphysema, and irreversible asthma. Treatment regimens generally include the administration of anti-interleukin-8 antibodies to the patient to reduce the severity of an inflammatory response by the patient's immune system.
    Type: Application
    Filed: March 18, 2003
    Publication date: December 18, 2003
    Inventors: Xiao-dong Yang, Gregory Bell, Ronald P. Gladue, Elizabeth M. Kudlacz, Henry J. Showell
  • Substituted piperidines useful for the treatment of allergic diseases
    Patent number: 6329392
    Abstract: The present invention relates to novel substituted piperidine derivatives of the formula stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic diseases including: seasonal rhinitis, allergic rhinitis, and sinusitis.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: December 11, 2001
    Assignee: Aventis Pharmaceuticals, Inc.
    Inventors: Timothy P. Burkholder, Larry D. Bratton, Elizabeth M. Kudlacz, George P. Maynard, John M. Kane, Braulio Santiago
  • Carboxy substituted acylic carboxamide derivatives
    Patent number: 6316445
    Abstract: The present invention relates to novel carboxy substituted acyclic carboxamide derivatives of formula (1)): and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: November 13, 2001
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Timothy P. Burkholder, George D. Maynard, Elizabeth M. Kudlacz
  • Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl) benzamides useful for the treatment of allergic diseases
    Patent number: 6297259
    Abstract: The present invention relates to novel substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamide derivatives of the formula stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: October 2, 2001
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: George P. Maynard, John M. Kane, Larry D. Bratton, Elizabeth M. Kudlacz
  • Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
    Patent number: 6211199
    Abstract: The present invention relates to novel substituted piperidine derivatives of formula (1), stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
    Type: Grant
    Filed: December 15, 1997
    Date of Patent: April 3, 2001
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: John M. Kane, George D. Maynard, Timothy P. Burkholder, Larry D. Bratton, Christopher R. Dalton, Braulio Santiago, Elizabeth M. Kudlacz
  • Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
    Patent number: 6194406
    Abstract: The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula (1): and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: February 27, 2001
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: John M. Kane, George D. Maynard, Timothy P. Burkholder, Larry D. Bratton, Christopher R. Dalton, Elizabeth M. Kudlacz, Braulio Santiago
  • Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
    Patent number: 5998439
    Abstract: The present invention relates to novel substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamide derivatives of the formula ##STR1## stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: December 7, 1999
    Assignee: Hoescht Marion Roussel, Inc.
    Inventors: George P. Maynard, John M. Kane, Larry D. Bratton, Elizabeth M. Kudlacz
  • Carboxysubstituted cyclic carboxamide derivatives
    Patent number: 5977139
    Abstract: The present invention relates to novel carboxy substituted cyclic carboxamide derivatives of formula (1), ##STR1## and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, coughs and bronchitis.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: November 2, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Timothy P. Burkholder, George D. Maynard, Elizabeth M. Kudlacz
  • Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
    Patent number: 5932571
    Abstract: The present invention relates to novel N-methyl-N-(4-(4-(1H-benzimidazol-2-yl)?1,4!diazepan-1-yl)-2-(aryl)butyl)b enzamide derivatives of the formula: ##STR1## stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: August 3, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: George D. Maynard, John M. Kane, Christopher R. Dalton, Braulio Santiago, Elizabeth M. Kudlacz, Larry D. Bratton
  • Heterocyclic substituted piperazinone derivatives
    Patent number: 5864045
    Abstract: The present invention relates to substituted piperazinone derivatives of formula (1) or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis. The present invention also relates to intermediates useful in the preparation of compounds of formula (1).
    Type: Grant
    Filed: April 27, 1998
    Date of Patent: January 26, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Timothy P. Burkholder, Elizabeth M. Kudlacz, Tieu-Binh Le
  • Substituted pyrrolidin-3-yl-alkyl-piperidines
    Patent number: 5861416
    Abstract: The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: January 19, 1999
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Timothy P. Burkholder, Tieu-Binh Le, Elizabeth M. Kudlacz, George D. Maynard
  • Heterocyclic substituted pyrrolidine amide derivatives
    Patent number: 5861417
    Abstract: The present invention relates to novel heterocyclic substituted pyrrolidine amide derivatives of formula (1), ##STR1## and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.
    Type: Grant
    Filed: December 15, 1997
    Date of Patent: January 19, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Timothy P. Burkholder, George D. Maynard, Elizabeth M. Kudlacz
  • Heterocyclic substituted piperazinone derivatives
    Patent number: 5840726
    Abstract: The present invention relates to substituted piperazinone derivatives (compounds of formula (1)) or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis. The present invention also relates to intermediates useful in the preparation of compounds of formula (1).
    Type: Grant
    Filed: June 19, 1997
    Date of Patent: November 24, 1998
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Timothy P. Burkholder, Elizabeth M. Kudlacz, Tieu-Binh Le
  • Substituted pyrrolidin-3-yl-alkyl-piperidines
    Patent number: 5824690
    Abstract: The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein.
    Type: Grant
    Filed: February 11, 1997
    Date of Patent: October 20, 1998
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Timothy P. Burkholder, Elizabeth M. Kudlacz, Tieu-Bihn Le, George D. Maynard
  • Substituted piperazine derivatives
    Patent number: 5672602
    Abstract: The present invention relates to substituted piperazine derivatives (herein referred to as compounds or compounds of formula (1)) or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.
    Type: Grant
    Filed: April 30, 1996
    Date of Patent: September 30, 1997
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Timothy P. Burkholder, Tieu-Binh Le, Elizabeth M. Kudlacz
  • Substituted pyrrolidin-3-yl-alkyl-piperidines
    Patent number: 5661160
    Abstract: The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 26, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Timothy P. Burkholder, Tieu-Binh Le, Elizabeth M. Kudlacz, George D. Maynard
  • Substituted pyrrolidin-3-yl-alkyl-piperidines
    Patent number: 5648366
    Abstract: The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 15, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Timothy P. Burkholder, Tieu-Binh Le, Elizabeth M. Kudlacz, George D. Maynard
  • Substituted pyrrolidin-3-yl-alkyl-piperidines
    Patent number: 5635510
    Abstract: The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: June 3, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Timothy P. Burkholder, Elizabeth M. Kudlacz, George D. Maynard
  • Substituted alkyldiamine derivatives
    Patent number: 5597845
    Abstract: The present invention relates to novel substituted alkyldiamine derivatives and pharmaceutically acceptable salts thereof which are useful tachykinin antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions including asthma, cough, and bronchitis.
    Type: Grant
    Filed: June 20, 1994
    Date of Patent: January 28, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Timothy P. Burkholder, Elizabeth M. Kudlacz, Tieu-Binh Le
  • Cyclic neurokinin A antagonists
    Patent number: 5521156
    Abstract: Antagonists of neurokinin A which are novel cyclic hexapeptide and octapeptide compounds are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions in which neurokinin A is implicated is also described.
    Type: Grant
    Filed: February 3, 1994
    Date of Patent: May 28, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Thomas J. Owen, Elizabeth M. Kudlacz, Scott L. Harbeson, Stephen H. Buck