Abstract: A method and system for hotspot configuration. The method includes: receiving a digital image; receiving one or more hotspot markers for the digital image, wherein the hotspot markers indicate a location of a hotspot in the digital image; preparing a grid to be superimposed over the digital image; displaying the digital image, hotspot markers, and grid; allowing a user to enter alternative text describing the content of the hotspot identified by the hotspot marker; allowing a user to edit the grid, hotspot markers and alternative text; and determining if the grid is valid based on the locations of the hotspot markers within the grid, if not, notifying the user and return to allowing the user to edit; and if so, output the finalized digital image with hotspot markers and alternative text. The system includes a processor, a computer memory, and modules configured to perform the method noted above.

Abstract: In general, disclosed herein are methods of treating an inflammatory disease or disorder by administering to the subject in need thereof a polyacetylene compound. The polyacetylene compound may be administered at a dose of from about 1 mg/kg body weight to about 10 mg/kg body weight.

Abstract: A processor-implemented method is disclosed.

Abstract: Embodiments are provided that include maintaining a map of a plurality of markers in an environment. The map includes a last detection time of each marker of the plurality of markers. The embodiments also include receiving a set of detected markers from a robotic device that is configured to localize in the environment using the plurality of markers. The embodiments further include updating, in the map, the last detection time of each marker which has a mapped position that corresponds to a detected position of a detected marker in the set of detected markers. The embodiments additionally include identifying, from the plurality of markers in the map, a marker having a last detection time older than a threshold amount of time. The embodiments still further include initiating an action related to the identified marker.

Abstract: One method disclosed includes identifying, in a map of markers fixed in an environment, two co-located markers within a threshold distance of each other, where each of the two co-located markers has a non-overlapping visibility region. The method further includes determining a set of detected markers based on sensor data from a robotic device. The method additionally includes identifying, from the set of detected markers, a detected marker proximate to a first marker of the two co-located markers. The method also includes enforcing a visibility constraint based on the non-overlapping visibility region of each of the two co-located markers to determine an association between the detected marker and a second marker of the two co-located markers. The method further includes determining a location of the robotic device in the environment relative to the map based on the determined association.

Abstract: A processor-implemented method is disclosed.

Abstract: Methods are described for use in treatment of gastrointestinal cancers such as colorectal cancers, gastric cancer, intestinal cancers, and adenocarcinomas. Methods utilize emodin in prevention or inhibition of tumorigenesis. Methods can encompass utilization of emodin as a therapy for gastrointestinal cancer as the sole treatment or in conjunction with other drugs or therapies useful in treating the pathology. Emodin is also useful in decreasing side effects of chemotherapy. Emodin may be utilized in a therapy protocol for gastrointestinal cancer therapy in combination with other chemotherapies such as 5 fluorouracil for mitigating side effects including inflammation and improving quality of life for chemotherapy patients.

Abstract: One method disclosed includes identifying, in a map of markers fixed in an environment, two co-located markers within a threshold distance of each other, where each of the two co-located markers has a non-overlapping visibility region. The method further includes determining a set of detected markers based on sensor data from a robotic device. The method additionally includes identifying, from the set of detected markers, a detected marker proximate to a first marker of the two co-located markers. The method also includes enforcing a visibility constraint based on the non-overlapping visibility region of each of the two co-located markers to determine an association between the detected marker and a second marker of the two co-located markers. The method further includes determining a location of the robotic device in the environment relative to the map based on the determined association.

Abstract: One method disclosed includes determining a map of markers fixed in an environment, where the map of markers includes a location and an orientation of each marker. The method further includes determining locations of a set of detected markers relative to the map based on a location of a robotic device relative to the map and based on sensor data from the robotic device. The method also includes associating a detected marker from the set of detected markers with a mapped marker based on the determined location of the detected marker relative to the map and based on a visibility constraint related to the orientation of the mapped marker. The method additionally includes adjusting, in the map, the orientation of the mapped marker based on the determined location of the detected marker relative to the map.

Abstract: One method disclosed includes identifying, in a map of markers fixed in an environment, two co-located markers within a threshold distance of each other, where each of the two co-located markers has a non-overlapping visibility region. The method further includes determining a set of detected markers based on sensor data from a robotic device. The method additionally includes identifying, from the set of detected markers, a detected marker proximate to a first marker of the two co-located markers. The method also includes enforcing a visibility constraint based on the non-overlapping visibility region of each of the two co-located markers to determine an association between the detected marker and a second marker of the two co-located markers. The method further includes determining a location of the robotic device in the environment relative to the map based on the determined association.

Abstract: Embodiments are provided that include maintaining a map of a plurality of markers in an environment. The map includes a last detection time of each marker of the plurality of markers. The embodiments also include receiving a set of detected markers from a robotic device that is configured to localize in the environment using the plurality of markers. The embodiments further include updating, in the map, the last detection time of each marker which has a mapped position that corresponds to a detected position of a detected marker in the set of detected markers. The embodiments additionally include identifying, from the plurality of markers in the map, a marker having a last detection time older than a threshold amount of time. The embodiments still further include initiating an action related to the identified marker.

Abstract: One method disclosed includes identifying, in a map of markers fixed in an environment, two co-located markers within a threshold distance of each other, where each of the two co-located markers has a non-overlapping visibility region. The method further includes determining a set of detected markers based on sensor data from a robotic device. The method additionally includes identifying, from the set of detected markers, a detected marker proximate to a first marker of the two co-located markers. The method also includes enforcing a visibility constraint based on the non-overlapping visibility region of each of the two co-located markers to determine an association between the detected marker and a second marker of the two co-located markers. The method further includes determining a location of the robotic device in the environment relative to the map based on the determined association.

Abstract: One method disclosed includes determining a map of markers fixed in an environment, where the map of markers includes a location and an orientation of each marker. The method further includes determining locations of a set of detected markers relative to the map based on a location of a robotic device relative to the map and based on sensor data from the robotic device. The method also includes associating a detected marker from the set of detected markers with a mapped marker based on the determined location of the detected marker relative to the map and based on a visibility constraint related to the orientation of the mapped marker. The method additionally includes adjusting, in the map, the orientation of the mapped marker based on the determined location of the detected marker relative to the map.

Abstract: Methods are described for use in treatment of gastrointestinal cancers such as colorectal cancers, gastric cancer, intestinal cancers, and adenocarcinomas. Methods utilize emodin in prevention or inhibition of tumorigenesis. Methods can encompass utilization of emodin as a therapy for gastrointestinal cancer as the sole treatment or in conjunction with other drugs or therapies useful in treating the pathology. Emodin is also useful in decreasing side effects of chemotherapy. Emodin may be utilized in a therapy protocol for gastrointestinal cancer therapy in combination with other chemotherapies such as 5 fluorouracil for mitigating side effects including inflammation and improving quality of life for chemotherapy patients.

Abstract: Compositions and methods that include stabilized protein drugs are described. In addition, protein drug formulations that are more stable under ambient conditions are described. The formulations include one or more poly amino acid ligands of the protein drug.

Abstract: Compositions and methods that include stabilized protein drugs are described. In addition, protein drug formulations that are more stable under ambient conditions are described. The formulations include one or more poly amino acid ligands of the protein drug.

Abstract: Compositions and methods that include stabilized protein drugs are described. In addition, protein drug formulations that are more stable under ambient conditions are described. The formulations include one or more polyamino acid ligands of the protein drug.

Abstract: A novel monomer, 1,1,1-tri-[4-(methacryloxyethylaminocarbonyloxy)-phenyl]ethane (MPE) can be used in preparing dental compositions The MPE monomer can be combined into a dental adhesive with hydroxyethyl methacrylate (HEMA) and BisGMA (bisphenol A dimethacrylate). The MPE polymer can be polymerized with a photoinitiator system, such as a system that includes an iodonium salt. The iodonium salt can be diphenyliodonium hexafluorophosphate.

Abstract: A novel monomer, 1,1,1-tri-[4-(methacryloxyethylaminocarbonyloxy)-phenyl]ethane (MPE) can be used in preparing dental compositions The MPE monomer can be combined into a dental adhesive with hydroxyethyl methacrylate (HEMA) and BisGMA (bisphenol A dimethacrylate). The MPE polymer can be polymerized with a photoinitiator system, such as a system that includes an iodonium salt. The iodonium salt can be diphenyliodonium hexafluorophosphate.

Abstract: A soluble protein having IL4 and/or IL13 antagonist or partial antagonist activity comprises an IL4 mutant or variant fused to least one human immunoglobulin constant domain or fragment thereof.