Patents by Inventor Elizabeth Nabel

Elizabeth Nabel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for coating stents with DNA and expression of recombinant genes from DNA coated stents in vivo
    Publication number: 20080112997
    Abstract: The present invention describes DNA coated stents and methods of using the same to treat or prevent vascular diseases, such as restenosis.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 15, 2008
    Inventors: Elizabeth Nabel, Gary Natel, Zhi-Yong Yang
  • Methods for treating cancers and restenosis with P21
    Publication number: 20080095835
    Abstract: The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G0/G1, alteration in morphology, and cell differentiation.
    Type: Application
    Filed: October 31, 2007
    Publication date: April 24, 2008
    Inventors: Gary Nabel, Zhi-yong Yang, Elizabeth Nabel
  • Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
    Publication number: 20070287682
    Abstract: A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothelial cells expressing recombinant therapeutic agent or diagnostic proteins are situated on the walls of the blood vessel or in the tissue perfused by the vessel in a patient. This technique, provides for the transfer of cells or vectors and expression of recombinant genes in vivo and allows the introduction of proteins of therapeutic or diagnostic value for the treatment of diseases.
    Type: Application
    Filed: April 20, 2007
    Publication date: December 13, 2007
    Inventors: Elizabeth Nabel, Gary Nabel
  • Protein Arginine N-Methyltransferase 2 (PRMT-2)
    Publication number: 20060239990
    Abstract: The invention provides insight into the function of Protein Arginine N-Methyltransferase-2 (PRMT-2) and provides methods for modulating PRMT-2 activity or expression in cells. The methods of the invention can be used to inhibit the function of NF?B, E2F1 and STAT3 and have utility for treating a variety of conditions including, for example, inflammation, HIV infection, cancer and obesity.
    Type: Application
    Filed: October 31, 2005
    Publication date: October 26, 2006
    Inventors: Elizabeth Nabel, Gary Nabel, Takanobu Yoshimoto, Hiroaki Iwasaki
  • Methods for treating cancers and restenosis with p21
    Publication number: 20060239975
    Abstract: The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G0/G1, alteration in morphology, and cell differentiation.
    Type: Application
    Filed: June 27, 2006
    Publication date: October 26, 2006
    Inventors: Gary Nabel, Zhi-yong Yang, Elizabeth Nabel
  • hKIS compositions and methods of use
    Publication number: 20050203050
    Abstract: Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.
    Type: Application
    Filed: May 12, 2005
    Publication date: September 15, 2005
    Inventors: Gary Nabel, Elizabeth Nabel, Manfred Boehm
  • Methods for coating stents with DNA and expression of recombinant genes from DNA coated stents in vivo
    Publication number: 20050038499
    Abstract: The present invention describes DNA coated stents and methods of using the same to treat or prevent vascular diseases, such as restenosis.
    Type: Application
    Filed: September 22, 2004
    Publication date: February 17, 2005
    Inventors: Elizabeth Nabel, Gary Nabel, Zhi-yong Yang