Patents by Inventor Elizabeth Naylor

Elizabeth Naylor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaryl piperidine glycine transporter inhibitors
    Patent number: 7825135
    Abstract: The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
    Type: Grant
    Filed: March 23, 2005
    Date of Patent: November 2, 2010
    Assignees: Merck Sharp & Dohme Limited, Merck Sharp & Dohme Corp.
    Inventors: Wesley Blackaby, Mark E. Duggan, David Hallett, George D. Hartman, Andrew S. Jennings, William H. Leister, Richard T. Lewis, Craig W. Lindsley, Elizabeth Naylor, Leslie J. Street, Yi Wang, David D. Wisnoski, Scott E. Wolkenberg, Zhijian Zhao
  • Piperidine And Azetidine Derivatives As Glyt1 Inhibitors
    Publication number: 20080090796
    Abstract: The present invention provides compounds of formula (I), wherein both p's are one or two, R1 is generally heteroaryl or cycloalkyl, R2 is C3-6cycloalkyl or phenyl and R3 is heteroaryl, and pharmaceutically acceptable salts thereof, as GlyT1 inhibitors for treating schizophrenia, pharmaceutical compositions comprising the same and methods for their preparation.
    Type: Application
    Filed: December 21, 2005
    Publication date: April 17, 2008
    Inventors: Wesley Blackaby, Stephen Fletcher, Andrew Jennings, Richard Lewis, Elizabeth Naylor, Leslie Joseph, Joanne Thomson
  • Heteroaryl Piperidine Glycine Transporter Inhibitors
    Publication number: 20070254880
    Abstract: The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
    Type: Application
    Filed: March 23, 2005
    Publication date: November 1, 2007
    Inventors: Wesley Blackaby, Mark Duggan, David Hallett, George Hartman, Andrew Jennings, William Leister, Richard Lewis, Craig Lindsley, Elizabeth Naylor, Leslie Street, Yi Wang, David Wisnoski, Scott Wolkenberg, Zhijian Zhao
  • Cyclohexanesulfonyl derivatives as GlyT1 inhibitors to treat schizophrenia
    Publication number: 20060276655
    Abstract: The present invention provides compounds of formula I: wherein R1 is an alkyl, phenyl, heterocyclyl, cycloalkyl, alkoxy, ester, amino or amide group; R2 is a phenyl, heterocyclyl, alkyl, cycloalkyl or cycloalkylalkyl group; R3 is an alkyl, cycloalkyl, cycloalkylalkyl, amino or heterocyclyl group; R4 and R5 are hydrogen or alkyl or form a cycloalkyl ring; A is O or N; and m is zero or one; as inhibitors of GlyT1 and thus as useful for treating or preventing diseases such as schizophrenia; with the provision of pharmaceutical compositions, first and second medical uses and methods of treatment.
    Type: Application
    Filed: June 5, 2006
    Publication date: December 7, 2006
    Inventors: Wesley Blackaby, Jose Castro Pineiro, Richard Lewis, Elizabeth Naylor, Leslie Street