Abstract: The present disclosure describes various improvements for programmable nuclease-based detection assays. Also provided are compositions, methods, kits, systems, and devices for practicing the same. Such improvements include improved reporter designs to facilitate the cleavage of a reporter immobilized on a substrate by an activated programmable nuclease. Improved reporter designs may comprise various lengths and structures of the reporter. The substrate can also comprise immobilized guide nucleic acids and/or programmable nucleases.

Abstract: Belts and sanitary tissue products of the present disclosure may comprise discrete cells of multiple sizes (including three different cell sizes) and/or certain patterns. The cells may be discrete knuckles or pillows and the fibrous structures may further comprise an emboss, such as a double dot emboss.

Abstract: Various embodiments of a system and method for a smart work zone are described. In one example, the system includes smart cone devices configured to transmit smart cone device localization data, a wearable device comprising a processor configured to transmit worker localization data of a worker wearing the garment device and to receive an alert, and a base station. The base station includes an internal edge computing system configured to process the smart cone device localization data to define a virtual geofence boundary of a safe area, process the worker localization data, broadcast a location of the worker wearing the wearable device, and in response to a vehicle or the worker approaching the virtual geofence boundary, provide an alert to at least one of: the worker wearing the wearable device, a passing motorist, or a connected and automated vehicle (CAV).

Abstract: A power distribution unit (PDU) includes a housing configured to be mounted into or on a rack that has a plurality of shelf positions for a variety of computing equipment, networking equipment or data storage equipment. The PDU includes power inputs. The power inputs are configured to receive one or more of: alternating current (AC) power, high voltage direct current (DC) power, single-phase fault managed power, or multi-phase fault managed power. The PDU further includes at least one fault managed power module configured to be contained in the housing, the at least one fault managed power module including a power transmitter configured to generate single-phase or multi-phase fault managed power from the AC power and/or high voltage DC power. The PDU also includes a plurality of connectors on the housing and configured to provide cable connections to one or more of the plurality of shelf positions of the rack.

Abstract: A temperature sensor has a heat-sensitive element contained within a chamber, the heat-sensitive element changing from a first configuration to a second configuration at a predetermined temperature, and a biased member biased towards the chamber. The biased member initially is prevented from entering the chamber when the heat-sensitive element is in the first configuration and enters the chamber when the heat-sensitive element is in the second configuration. In some aspects, the first configuration is solid and the second configuration is liquid and a selectively permeable element is provided to allow the heat-sensitive element to exit the chamber in the liquid configuration. An indicator can be provided that has a plurality of feet initially held in a retained configuration by the biased member until the biased member enters the chamber to release the feet for sliding motion of the indicator.

Abstract: A device for applying a tactile stimulus, comprising a finger sleeve with one or more raised elements on its outer surface, wherein there is at least one raised element or part thereof in that region of the sleeve defined by the first 15% of its overall length measured from its distal end, and wherein the raised element(s) are arranged in a loop surrounding a blank region of the sleeve which carries no raised elements. The raised element(s) may define a fluid retaining region on the sleeve surface. A region of the sleeve may have a greater flexibility than that of the rest of the sleeve, so as to provide variability in circumference. The device is of particular use in the treatment of female orgasmic disorders and may be used to apply a fluid substance as well as a tactile stimulus.

Abstract: An applicator and stimulator device comprises a flexible sleeve closed at one end and having a one or more indented cells in its outer wall and adapted to accomodate a human finger within the sleeve. In order to assist application of fluids it may have one or more cells associated with the outer wall which contain fluid which is retained by a seal. The seal is openable or rupturable when pressure is applied across the wall or the wall is in contact with an environment that weakens the seal. The sleeve is formed from an elastic material such as natural or a synthetic rubber such as a highly plasticised PVC resin. The cells associated with the outer wall are formed by creating depressions in the wall during moulding of the device. In its unflexed state the body of the sleeve is substantially cylindrical and the cells are preferably formed on a portion of the sleeve surface near to the closed end sustaining and angle of about 90 degrees over the surface measured from the axis of the cylinder.

Abstract: A device 10 for use in delivering an aroma, the device comprising lint 4 or similar material impregnated with the substance giving the desired aroma, the lint being incorporated into an adhesive plaster or patch 2 for application to the skin.