Abstract: The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: W—X—Y—Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: Provided are systems and methods for producing seamless woven materials that are variable in each of their 3 dimensions. The systems and methods generally operate by altering heddle positions independently to impart three dimensional structure to a woven fabric. Weft yarn is woven into a set of warp yarns that have been individually raised or lowered along a particular cross section, essentially locking the weave into an intended 3 dimensional form.

Abstract: An example computer-implemented method of increasing veterinary health care compliance includes receiving information indicating that an animal patient concluded a visit at a veterinary practice, in response accessing diagnostic test results for the animal patient, based on the diagnostic test results creating a pet owner profile for an owner of the animal patient, matching the pet owner profile with a stored message and stored information relating to a product associated with recommended treatment for the animal patient, sending an electronic message to a second computing device associated with the owner of the animal patient that includes the stored message and the stored information relating to the product associated with recommended treatment for the animal patient, receiving a report indicating whether the owner of the animal patient obtained the product associated with recommended treatment for the animal patient, and updating the pet owner profile to be indicative of the report.

Abstract: A Self-Aligning Zipper is disclosed that allows for one handed operation by anyone who would, otherwise use a zipper or use of the Self-Aligning Zipper by those with physical and developmental limitations or equipment such, as cold weather gloves or mittens. The proper alignment of each half of the Self-Aligning Zipper is accomplished by way of magnets of opposite polarity along with structural guide elements to ensure proper alignment and operation of the zipper.

Abstract: A fastening device that provides for ease of alignment and operation. The fastening device has a first locking body having a first magnet, a second locking body having a second magnet, a slider body slidably connected to a first zipper track, the first locking body affixed to the first zipper track, and the second locking body affixed to a second zipper track. The first and second locking bodies reversibly form a single element while in use through the attractive force of the first and second magnets.

Abstract: A Self-Aligning Zipper is disclosed that allows for one handed operation by anyone who would, otherwise use a zipper or use of the Self-Aligning Zipper by those with physical and developmental limitations or equipment such, as cold weather gloves or mittens. The proper alignment of each half of the Self-Aligning Zipper is accomplished by way of magnets of opposite polarity along with structural guide elements to ensure proper alignment and operation of the zipper.

Abstract: A fastening device that provides for ease of alignment and operation. The fastening device has a first locking body having a first magnet, a second locking body having a second magnet, a slider body slidably connected to a first zipper track, the first locking body affixed to the first zipper track, and the second locking body affixed to a second zipper track. The first and second locking bodies reversibly form a single element while in use through the attractive force of the first and second magnets.

Abstract: The present invention provides the use of an aerosol formulation comprising fosfomycin and tobramycin in the treatment of patients with chronic obstructive pulmonary disease (COPD) who are experiencing or are at risk of experiencing acute exacerbations of COPD. Formulations for such use and methods of treating humans with COPD are also provided.