Patents by Inventor Elizabeth S. Dhummakupt

Elizabeth S. Dhummakupt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mass spectrometry ionization based-assay for the detection of enzyme activity and/or presence
    Patent number: 11913059
    Abstract: An apparatus and method for detecting an analyte of interest using paper spray mass spectrometry includes a spray material; a sample on the spray material including an enzyme of interest; a solvent to hydrate the sample, promote enzymatic activity, and extract analytes of interest from the sample; a substrate specific to the enzyme of interest, wherein any of the spray material and the solvent includes the substrate; a voltage source to apply a voltage to the spray material to create charged droplets of a mixture containing the sample; and a mass spectrometer to perform spectrometry on the droplets to perform any of: identify the analytes of interest in the sample; and measure a level of inhibition in any enzymes contained in the sample.
    Type: Grant
    Filed: October 26, 2021
    Date of Patent: February 27, 2024
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Trevor G Glaros, Elizabeth S Dhummakupt, Phillip M Mach, Daniel O Carmany
  • Mass spectrometry ionization based-assay for the detection of enzyme activity and/or presence
    Patent number: 11162128
    Abstract: An apparatus and method for detecting an analyte of interest using paper spray mass spectrometry includes a spray material; a sample on the spray material including an enzyme of interest; a solvent to hydrate the sample, promote enzymatic activity, and extract analytes of interest from the sample; a substrate specific to the enzyme of interest, wherein any of the spray material and the solvent includes the substrate; a voltage source to apply a voltage to the spray material to create charged droplets of a mixture containing the sample; and a mass spectrometer to perform spectrometry on the droplets to perform any of: identify the analytes of interest in the sample; and measure a level of inhibition in any enzymes contained in the sample.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: November 2, 2021
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Trevor G Glaros, Elizabeth S Dhummakupt, Phillip M. Mach, Daniel O Carmany
  • Direct capture and analysis of aerosols and vapors by paper spray mass spectrometry
    Patent number: 10591390
    Abstract: An apparatus and method to capture aerosols and vapors on substrates from a large variety of sources and matrices for analysis using paper spray mass spectrometry (PS-MS) is disclosed. A holder for a PS cartridge has better direct sampling efficiency, direct capture on substrate, and lower limits of detection thereby improving the collection and analysis of aerosols and vapors. An apparatus and method for aerosol and vapor collection, from both anthropogenic and environmental sources, for example, that is compact and compatible with hand held devices and unmanned vehicles is also disclosed.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: March 17, 2020
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Trevor G. Glaros, John M Nilles, Jennifer W Sekowski, Harold S Wylie, Elizabeth S. Dhummakupt, Phillip M Mach