Patents by Inventor Elizabeth S. Stuart

Elizabeth S. Stuart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vitamin E tocotrienols inhibition of intracellularly obligate pathogen Chlamydia and methods of use
    Publication number: 20180200369
    Abstract: This invention reveals the beneficial use of vitamin E tocotrienols for inhibition of chlamydial infections. Chlamydial infection levels in mouse macrophages treated with tocotrienol were decreased >50%, with concomitant aberrant pathogen development. The number of large and small inclusions in tocotrienol-versus-control cells was decreased 3-fold and 2-fold, respectively. When treated with delta tocotrienol, Chlamydia in human lymphocytes was inhibited by at least 2.6-fold in 1.5 days. Dietary delta tocotrienol inhibited Chlamydia infection and persistence in hypercholesterolemic patients with a corresponding drop in LDL. These studies demonstrate that tocotrienol lowers cholesterol, thus preventing or diminishing the cholesterol hijacking by Chlamydia obligatory for its infectivity and replication. Therefore, hypolipidemic agents used to treat cardiovascular diseases, metabolic syndrome, and diabetes are used as monotherapies, or in combination with tocotrienol to treat Chlamydia.
    Type: Application
    Filed: January 22, 2017
    Publication date: July 19, 2018
    Inventors: Barrie TAN, Anne Mueller, Elizabeth S. Stuart
  • Detection and quantification of intracellular pathogens
    Patent number: 7455985
    Abstract: The present invention provides methods and compositions for detecting bacteria of the Chlamydiaceae family in a biological sample. Methods include, for example, contacting a biological sample with an antibody that specifically binds to a chlamydial antigen displayed on the surface of a chlamydia-infected blood cell; and analyzing the sample using fluorescence microscopy or flow cytometry to detect bound antibody.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: November 25, 2008
    Assignee: University of Massachusetts
    Inventors: Elizabeth S. Stuart, Lloyd H. Semprevivo
  • Chlamydial glycolipid vaccines
    Publication number: 20020001597
    Abstract: Disclosed are compositions for and methods of eliciting in a vertebrate a protective immune response against a member of the genus Chlamydia. The methods include administering to the vertebrate a composition having a carrier group coupled to an oligosaccharide obtained from a chlamydial glycolipid. The composition is administered in an amount sufficient to elicit a protective immune response against the parasite.
    Type: Application
    Filed: April 6, 2001
    Publication date: January 3, 2002
    Inventors: Elizabeth S. Stuart, Lloyd H. Semprevivo, Gary J. Vora, Erin E. Davis
  • Method for diagnosing a patient for chlamydia
    Patent number: 5716793
    Abstract: A method of detecting chlamydia in a extracellular sample is provided which comprises contacting the sample with an idiotypic antibody to GLXA to form an immunocomplex and detecting the immunocomplex.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: February 10, 1998
    Assignee: Animal House, Inc.
    Inventors: Alex Bruce MacDonald, Elizabeth S. Stuart, Ling Ling An, Myron D. Whipkey