Patents by Inventor Elizabeth Sara Hecht

Elizabeth Sara Hecht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Middle Down Antibody Characterization
    Publication number: 20230221333
    Abstract: This disclosure relates to new methods for antibody characterization sequencing, such as middle down antibody characterization and sequencing, for example, for de novo antibody sequencing, identifying known antibodies in a sample, or verifying the sequence of antibodies in a sample. In some embodiments, the methods involve exposing antibodies to cathepsin D, cathepsin L, and/or cathepsin D and L, followed by mass spectrometry and sequence identification and deconvolution.
    Type: Application
    Filed: January 17, 2023
    Publication date: July 13, 2023
    Applicants: Genentech, Inc., Universiteit Utrecht Holding B.V.
    Inventors: Wendy Noel Sandoval, Tomislav Caval, Albert J.R. Heck, Elizabeth Sara Hecht
  • Structures for Reducing Antibody-Lipase Binding
    Publication number: 20230048743
    Abstract: The present application relates to recombinant antibodies that are engineered to alter interactions between the antibodies and one or more endogenous lipases of a host cell used to produce the antibodies. In some cases, the antibodies are mutated in the heavy chain constant region, such as at CH1, CH2, and/or CH3. In other cases, the antibodies are mutated to alter their glycosylation profile.
    Type: Application
    Filed: July 8, 2022
    Publication date: February 16, 2023
    Applicant: Genentech Inc.
    Inventors: Elizabeth Sara Hecht, Shrenik Chetan Mehta, Wendy Noel Sandoval, Sreedhara Alavattam, Nathaniel Robert Tzizik-Swanson