Patents by Inventor Elizabeth Smythe
Elizabeth Smythe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11788148Abstract: The present invention provides a method for predicting the treatment response of a human gastroesophageal cancer patient, the method comprising: a) measuring the gene expression of at least 3 of the following genes: CDH1, CDK6, COX2, ELOVL5, GATA4, EGFR, TBCEL, FGF7, CDH17, FNBP1, PIP5K1B, TWIST, CD44, MET, CEACAM1, TOX3, GLIPR2, GSTP1, RON, TMEM136, MYB, BRCA2, FGF1, POU5F1, EPR, DPYD, ABL2 and SH3RF1 in a sample obtained from the gastroesophageal tumour of the patient to obtain a sample gene expression profile of at least said genes; and b) making a prediction of the treatment response and/or prognosis of the patient based on the sample gene expression profile. Also provided are related computer-implemented methods and methods of treatment of gastroesophageal cancer.Type: GrantFiled: October 12, 2018Date of Patent: October 17, 2023Assignees: The Institute of Cancer Research: Royal Cancer Hospital, The Royal Marsden NHS Foundation Trust, National University of SingaporeInventors: Elizabeth Smyth, Anguraj Sadanandam, Gift Nyamundanda, David Cunningham, Boon Ooi Patrick Tan
-
Patent number: 11768191Abstract: Embodiments of the disclosure can include systems, methods, and devices for determining saturation pressure of an uncontaminated fluid. A technique facilitates fluid analysis in situ at a downhole location. Downhole saturation pressure measurements and downhole OBM filtrate contamination of a contaminated fluid may be obtained and a relationship may be determined between the saturation pressure measurements and OBM filtrate contamination. The relationship may be extrapolated to zero OBM filtrate contamination to determine the saturation pressure of the uncontaminated fluid. According to an embodiment, a sample of oil is obtained at the downhole location from oil in a reservoir. A downhole sampling system is used to determine whether a sample has contamination and other selected characteristics of the sample. The data obtained may be processed to provide a formation volume factor of the oil.Type: GrantFiled: May 13, 2021Date of Patent: September 26, 2023Assignee: SCHLUMBERGER TECHNOLOGY CORPORATIONInventors: Younes Jalali, Ryota Tonoue, Hua Chen, Christopher Harrison, Kamal Kader, Youxiang Zuo, Adriaan Gisolf, Cosan Ayan, Michael Mallari Toribio, Chetankumar Natwarlal Desai, Oliver Clinton Mullins, Matthew T. Sullivan, Elizabeth Smythe
-
Patent number: 11692991Abstract: Embodiments of the disclosure can include systems, methods, and devices for determining saturation pressure of an uncontaminated fluid. Downhole saturation pressure measurements and downhole OBM filtrate contamination of a contaminated fluid may be obtained and a relationship may be determined between the saturation pressure measurements and OBM filtrate contamination. The relationship may be extrapolated to zero OBM filtrate contamination to determine the saturation pressure of the uncontaminated fluid. In some embodiments, OBM filtrate contamination may be determined from downhole saturation pressure measurements during pumpout of a fluid.Type: GrantFiled: November 23, 2021Date of Patent: July 4, 2023Assignee: SCHLUMBERGER TECHNOLOGY CORPORATIONInventors: Youxiang Zuo, Christopher Harrison, Adriaan Gisolf, Cosan Ayan, Michael Mallari Toribio, Chetankumar Natwarlal Desai, Oliver Clinton Mullins, Matthew T. Sullivan, Elizabeth Smythe
-
Publication number: 20220082547Abstract: Embodiments of the disclosure can include systems, methods, and devices for determining saturation pressure of an uncontaminated fluid. Downhole saturation pressure measurements and downhole OBM filtrate contamination of a contaminated fluid may be obtained and a relationship may be determined between the saturation pressure measurements and OBM filtrate contamination. The relationship may be extrapolated to zero OBM filtrate contamination to determine the saturation pressure of the uncontaminated fluid. In some embodiments, OBM filtrate contamination may be determined from downhole saturation pressure measurements during pumpout of a fluid.Type: ApplicationFiled: November 23, 2021Publication date: March 17, 2022Inventors: Youxiang Zuo, Christopher Harrison, Adriaan Gisolf, Cosan Ayan, Michael Mallari Toribio, Chetankumar Natwarlal Desai, Oliver Clinton Mullins, Matthew T. Sullivan, Elizabeth Smythe
-
Patent number: 11187693Abstract: Embodiments of the disclosure can include systems, methods, and devices for determining saturation pressure of an uncontaminated fluid. Downhole saturation pressure measurements and downhole OBM filtrate contamination of a contaminated fluid may be obtained and a relationship may be determined between the saturation pressure measurements and OBM filtrate contamination. The relationship may be extrapolated to zero OBM filtrate contamination to determine the saturation pressure of the uncontaminated fluid. In some embodiments, OBM filtrate contamination may be determined from downhole saturation pressure measurements during pumpout of a fluid.Type: GrantFiled: August 5, 2019Date of Patent: November 30, 2021Assignee: SCHLUMBERGER TECHNOLOGY CORPORATIONInventors: Youxiang Zuo, Christopher Harrison, Adriaan Gisolf, Cosan Ayan, Michael Mallari Toribio, Chetankumar Natwarlal Desai, Oliver Clinton Mullins, Matthew T. Sullivan, Elizabeth Smythe
-
Publication number: 20210263008Abstract: Embodiments of the disclosure can include systems, methods, and devices for determining saturation pressure of an uncontaminated fluid. A technique facilitates fluid analysis in situ at a downhole location. Downhole saturation pressure measurements and downhole OBM filtrate contamination of a contaminated fluid may be obtained and a relationship may be determined between the saturation pressure measurements and OBM filtrate contamination. The relationship may be extrapolated to zero OBM filtrate contamination to determine the saturation pressure of the uncontaminated fluid. According to an embodiment, a sample of oil is obtained at the downhole location from oil in a reservoir. A downhole sampling system is used to determine whether a sample has contamination and other selected characteristics of the sample. The data obtained may be processed to provide a formation volume factor of the oil.Type: ApplicationFiled: May 13, 2021Publication date: August 26, 2021Inventors: Younes Jalali, Ryota Tonoue, Hua Chen, Christopher Harrison, Kamal Kader, Youxiang Zuo, Adriaan Gisolf, Cosan Ayan, Michael Mallari Toribio, Chetankumar Natwarlal Desai, Oliver Clinton Mullins, Matthew T. Sullivan, Elizabeth Smythe
-
Publication number: 20200239968Abstract: The present invention provides a method for predicting the treatment response of a human gastroesophageal cancer patient, the method comprising: a) measuring the gene expression of at least 3 of the following genes: CDH1, CDK6, COX2, ELOVL5, GATA4, EGFR, TBCEL, FGF7, CDH17, FNBP1, PIP5K1B, TWIST, CD44, MET, CEACAM1, TOX3, GLIPR2, GSTP1, RON, TMEM136, MYB, BRCA2, FGF1, POU5F1, EPR, DPYD, ABL2 and SH3RF1 in a sample obtained from the gastroesophageal tumour of the patient to obtain a sample gene expression profile of at least said genes; and b) making a prediction of the treatment response and/or prognosis of the patient based on the sample gene expression profile. Also provided are related computer-implemented methods and methods of treatment of gastroesophageal cancer.Type: ApplicationFiled: October 12, 2018Publication date: July 30, 2020Applicants: The Institute of Cancer Research: Royal Cancer Hospital, The Royal Marsden NHS Foundation Trust, National University of SingaporeInventors: Elizabeth Smyth, Anguraj Sadanandam, Gift Nyamundanda, David Cunningham, Boon Ooi Patrick Tan
-
Publication number: 20190360991Abstract: Embodiments of the disclosure can include systems, methods, and devices for determining saturation pressure of an uncontaminated fluid. Downhole saturation pressure measurements and downhole OBM filtrate contamination of a contaminated fluid may be obtained and a relationship may be determined between the saturation pressure measurements and OBM filtrate contamination. The relationship may be extrapolated to zero OBM filtrate contamination to determine the saturation pressure of the uncontaminated fluid. In some embodiments, OBM filtrate contamination may be determined from downhole saturation pressure measurements during pumpout of a fluid.Type: ApplicationFiled: August 5, 2019Publication date: November 28, 2019Inventors: Youxiang Zuo, Christopher Harrison, Adriaan Gisolf, Cosan Ayan, Michael Mallari Toribio, Chetankumar Natwarlal Desai, Oliver Clinton Mullins, Matthew T. Sullivan, Elizabeth Smythe
-
Patent number: 10371690Abstract: Embodiments of the disclosure can include systems, methods, and devices for determining saturation pressure of an uncontaminated fluid. Downhole saturation pressure measurements and downhole OBM filtrate contamination of a contaminated fluid may be obtained and a relationship may be determined between the saturation pressure measurements and OBM filtrate contamination. The relationship may be extrapolated to zero OBM filtrate contamination to determine the saturation pressure of the uncontaminated fluid. In some embodiments, OBM filtrate contamination may be determined from downhole saturation pressure measurements during pumpout of a fluid.Type: GrantFiled: November 6, 2014Date of Patent: August 6, 2019Assignee: SCHLUMBERGER TECHNOLOGY CORPORATIONInventors: Youxiang Zuo, Christopher Harrison, Adriaan Gisolf, Cosan Ayan, Michael Mallari Toribio, Chetankumar Natwarlal Desai, Oliver Clinton Mullins, Matthew T. Sullivan, Elizabeth Smythe
-
Patent number: 9689858Abstract: A method for determining an asphaltene onset condition of a crude oil is provided. The method includes receiving a crude oil within a downhole tool inside a well and taking a first measurement of an optical property of the received crude oil. The method also includes lowering the pressure or temperature of the crude oil after taking the first measurement of the optical property to cause aggregation of asphaltenes in the crude oil, and then separating aggregated asphaltenes from the crude oil. Further, the method includes taking a second measurement of the optical property of the crude oil within the downhole tool after separating aggregated asphaltenes from the crude oil and determining an asphaltene onset condition of the crude oil through comparison of the first and second measurements of the optical property. Additional methods, systems, and devices are also disclosed.Type: GrantFiled: October 21, 2015Date of Patent: June 27, 2017Assignee: SCHLUMBERGER TECHNOLOGY CORPORATIONInventors: John Ratulowski, Shahnawaz Molla, Vincent Sieben, Farshid Mostowfi, Shawn Taylor, Christopher Harrison, Shunsuke Fukagawa, Elizabeth Smythe, Matthew Sullivan, John Meier
-
Publication number: 20170115266Abstract: A method for determining an asphaltene onset condition of a crude oil is provided. The method includes receiving a crude oil within a downhole tool inside a well and taking a first measurement of an optical property of the received crude oil. The method also includes lowering the pressure or temperature of the crude oil after taking the first measurement of the optical property to cause aggregation of asphaltenes in the crude oil, and then separating aggregated asphaltenes from the crude oil. Further, the method includes taking a second measurement of the optical property of the crude oil within the downhole tool after separating aggregated asphaltenes from the crude oil and determining an asphaltene onset condition of the crude oil through comparison of the first and second measurements of the optical property. Additional methods, systems, and devices are also disclosed.Type: ApplicationFiled: October 21, 2015Publication date: April 27, 2017Inventors: John Ratulowski, Shahnawaz Molla, Vincent Sieben, Farshid Mostowfi, Shawn Taylor, Christopher Harrison, Shunsuke Fukagawa, Elizabeth Smythe, Matthew Sullivan, John Meier
-
Patent number: 9568459Abstract: Methods and systems for determining for determining asphaltene onset pressure of a formation fluid are described herein. The method includes the following processes: (a) transmitting light through a sample of the formation fluid; (b) decreasing pressure of the sample; (c) detecting intensity of the transmitted light during depressurization; (d) identifying a change in intensity of the transmitted light during depressurization; (e) increasing pressure of the sample to a fixed pressure; and (f) detecting intensity of the transmitted light at the fixed pressure and at an equilibrated light intensity. Processes (a) to (f) are repeated for a number of different fixed pressures. The asphaltene onset pressure of the formation fluid sample can be determined using (i) the intensity of the transmitted light during each depressurization and (ii) the intensity of the transmitted light at each of the different fixed pressures.Type: GrantFiled: April 25, 2014Date of Patent: February 14, 2017Assignee: SCHLUMBERGER TECHNOLOGY CORPORATIONInventors: Matthew T. Sullivan, Christopher Harrison, Shunsuke Fukagawa, Elizabeth Smythe, John Meier
-
Publication number: 20160131630Abstract: Embodiments of the disclosure can include systems, methods, and devices for determining saturation pressure of an uncontaminated fluid. Downhole saturation pressure measurements and downhole OBM filtrate contamination of a contaminated fluid may be obtained and a relationship may be determined between the saturation pressure measurements and OBM filtrate contamination. The relationship may be extrapolated to zero OBM filtrate contamination to determine the saturation pressure of the uncontaminated fluid. In some embodiments, OBM filtrate contamination may be determined from downhole saturation pressure measurements during pumpout of a fluid.Type: ApplicationFiled: November 6, 2014Publication date: May 12, 2016Inventors: Youxiang Zuo, Christopher Harrison, Adriaan Gisolf, Cosan Ayan, Michael Mallari Toribio, Chetankumar Natwarlal Desai, Oliver Clinton Mullins, Matthew T. Sullivan, Elizabeth Smythe
-
Patent number: 9335273Abstract: A method for characterizing the dielectric response of a fluid includes receiving the fluid into a portion of a flow line that is disposed proximate to a photonic bandgap (PBG) resonant cavity so that a dielectric permittivity of the fluid affects a frequency response of the resonant cavity. The method further includes providing electromagnetic waves to the resonant cavity and measuring a frequency response of the resonant cavity in the presence of the fluid in the flow line. The method further includes determining a property of a resonant mode of the resonant cavity using the frequency response and determining a property of the fluid using the property of the resonant mode.Type: GrantFiled: March 8, 2013Date of Patent: May 10, 2016Inventors: Tancredi Botto, Elizabeth Smythe
-
Publication number: 20160040533Abstract: A method and an apparatus for characterizing a fluid including a phase transition cell to receive the fluid, a piston to control fluid pressure, a pressure gauge to measure the fluid pressure and to provide information to control the piston, and connectors to connect the cell, piston, and gauge. The exterior volume of the phase transition cell, piston, gauge, and connectors is less than about 10 liters. A method and an apparatus to characterize a fluid including observing a fluid in an phase transition cell, measuring a pressure of the fluid, and adjusting a pressure control device in response to the measuring.Type: ApplicationFiled: February 10, 2014Publication date: February 11, 2016Inventors: Christopher Harrison, Matthew T. Sullivan, Elizabeth Smythe, Shunsuke Fukagawa, Robert J Schroeder
-
Patent number: 9249661Abstract: An apparatus and a method including exposing a first fluid to a pre-filter, observing the first fluid, introducing a second fluid to the first fluid, exposing the first and second fluids to a filter, and observing the first and second fluids wherein the observing the first fluid and observing the first and second fluids comprise optical measurements and the first fluid comprises material from a subterranean formation. Some embodiments may compare the optical measurements of the first fluid and the first and second fluids and/or estimate the first fluid's likelihood of forming precipitants with other fluids and/or the first fluid's asphaltene content.Type: GrantFiled: January 20, 2012Date of Patent: February 2, 2016Assignee: SCHLUMBERGER TECHNOLOGY CORPORATIONInventors: Christopher Harrison, Farshid Mostowfi, Matthew T. Sullivan, Elizabeth Smythe, Abdel M. Kharrat
-
Publication number: 20150354345Abstract: Methods and systems for determining the presence and/or rate of a flow of a fluid sample include transmitting light through the fluid sample are disclosed. The methods comprise, applying a series of thermal pulses to the fluid sample, the series comprises a time interval between each thermal pulse, detecting transmitted light using a light detector; and determining at least one of (a) whether or not the fluid is flowing and (b) a flow rate of the fluid, based on an intensity of the transmitted light corresponding to at least one time interval.Type: ApplicationFiled: June 3, 2015Publication date: December 10, 2015Inventors: John Meier, Elizabeth Smythe, Matthew T. Sullivan, Shunsuke Fukagawa, Christopher Harrison
-
Patent number: 8910514Abstract: Systems and methods of determining fluid properties are disclosed. An example apparatus to determine a saturation pressure of a fluid includes a housing having a detection chamber and a heater assembly partially positioned within the detection chamber to heat a fluid. The example apparatus also includes a sensor assembly to detect a property of the fluid and a processor to identify a saturation pressure of the fluid using the property of the fluid.Type: GrantFiled: February 24, 2012Date of Patent: December 16, 2014Assignee: Schlumberger Technology CorporationInventors: Matthew T. Sullivan, Christopher Harrison, Robert J. Schroeder, Ahmad Latifzai, Elizabeth Smythe, Shunsuke Fukagawa, Douglas W. Grant
-
Publication number: 20130219997Abstract: Systems and methods of determining fluid properties are disclosed. An example apparatus to determine a saturation pressure of a fluid includes a housing having a detection chamber and a heater assembly partially positioned within the detection chamber to heat a fluid. The example apparatus also includes a sensor assembly to detect a property of the fluid and a processor to identify a saturation pressure of the fluid using the property of the fluid.Type: ApplicationFiled: February 24, 2012Publication date: August 29, 2013Inventors: Matthew T. Sullivan, Christopher Harrison, Robert J. Schroeder, Ahmad Latifzai, Elizabeth Smythe, Shunsuke Fukagawa, Douglas W. Grant
-
Publication number: 20070058686Abstract: A new class of photonic devices called active optical antennas, which consist of metallic structures directly integrated on to the facet of a semiconductor lasers, and of instruments based on such antennas are disclosed. The structures consist of metallic elements which function as antennas at optical wavelengths by spatially concentrating laser radiation of wavelength in the range from the UV to the mid-infrared into spots (with sizes in the range 10-100 nm) in the so called near field zone, that is at subwavelength distances from the facet. Various antenna designs are considered depending on the laser under consideration and applications. This invention has wide ranging applications such as new microscopes for high-resolution spatially resolved imaging and spectroscopy, new probes for biology, laser assisted processing and repair of devices, circuits and masks, as well new optical tweezers and phased array devices. Microscopes and other systems based on this invention are discussed.Type: ApplicationFiled: August 15, 2006Publication date: March 15, 2007Inventors: Federico Capasso, Ken Crozier, Ertugrul Cubukcu, Eric Kort, Nanfang Yu, Elizabeth Smythe