Abstract: Epileptic seizures are difficult to diagnose and are often difficult to distinguish from several conditions with similar presentations, and therefore, diagnosis of seizures is often a long, expensive, and unreliable process. This invention provides biomarkers for identifying seizures and epilepsy, assays for measuring and assessing biomarker concentration, predictive models based on biomarkers and computational systems for detecting, assessing and diagnosing phasic and tonic changes associated with seizures and epilepsy in all clinical and healthcare settings. Diagnostic and treatment methods, systems, kits, and predictive models provided herein, provide quantitative and/or qualitative assessment in order to allow patients to proceed immediately to diagnostic and/or treatment protocols, and assess therapeutic treatment effectiveness.

Abstract: A tissue ablation device is provided including an inflatable balloon with a cavity. The tissue ablation device further includes a catheter with a lumen in fluid communication with the cavity of the inflatable balloon. The lumen of the catheter is configured to deliver a fluid to the cavity thereby causing the inflatable balloon to inflate and expand. The device also includes a heating element connected to the balloon, wherein the heating element is further connected to an electrical source. The heating element is configured to receive an electrical current from the electrical source. Further, the heating element is configured to raise the temperature of the inflatable balloon and the fluid when an electrical current is passed through the heating element.