Abstract: The present disclosure relates to a polymeric overcoating used as a splice protector, and a corresponding method of application where the resulting coated fusion spliced optical fibers or coated fusion spliced optical fiber ribbons can be bundled or stacked to reduce the size of splice protection.

Abstract: The present disclosure relates to a polymeric overcoating used as a splice protector, and a corresponding method of application where the resulting coated fusion spliced optical fibers or coated fusion spliced optical fiber ribbons can be bundled or stacked to reduce the size of splice protection.

Abstract: A lid for a multi-well plate having apertures, each aperture having a gas permeable membrane, and fittings extending from the bottom surface of the lid to fit with a multi-well plate to reduce evaporation of liquid contents from within the wells of the multi-well plate, protect the contents of a multi-well plate from spilling or from mingling with the contents of a neighboring well in a multi-well plate is disclosed. The gas permeable membrane comprises one or more of (i) a continuous or discontinuous thin film associated with each aperture, (ii) a locally-thinned portion of the main body, and (iii) a quantity of material at least partially filling each aperture.

Abstract: A lid for a multi-well plate having apertures, each aperture having a gas permeable membrane, and fittings extending from the bottom surface of the lid to fit with a multi-well plate to reduce evaporation of liquid contents from within the wells of the multi-well plate, protect the contents of a multi-well plate from spilling or from mingling with the contents of a neighboring well in a multi-well plate is disclosed. The gas permeable membrane comprises one or more of (i) a continuous or discontinuous thin film associated with each aperture, (ii) a locally-thinned portion of the main body, and (iii) a quantity of material at least partially filling each aperture.

Abstract: A method for hit compound identification in a high throughput, label-free biosensor cellular assay, one method including, for example: generating at least one pathway-specific kinetic profile for a target receptor; generating a relational table that integrates each kinetic profile; determining a delta response with the relational table for candidate compounds screened against the target receptor; and identifying one or more hit compounds based upon the separation of the delta response from a threshold.

Abstract: This disclosure relates to devices and methods for cell-exclusion patterning. Specifically, this disclosure provides a device and method to exclude cells in selected areas during cell seeding and create cell-free arrays that can be used for cell migration and related studies and assays.

Abstract: A method and apparatus, as defined herein, for use in compound screening, compound profiling, or both assays, for example, against two different cellular targets in, for example, a single cell-type.

Abstract: A method and apparatus, as defined herein, for use in compound screening, compound profiling, or both assays, for example, against two different cellular targets in, for example, a single cell-type.

Abstract: The disclosure provides methods for characterizing the toxicity of a candidate molecule to liver cells as defined herein; methods of culturing metabolically active liver cells on a biosensor as defined herein; and biosensor liver culture systems as defined herein.

Abstract: This disclosure relates to devices and methods for cell-exclusion patterning. Specifically, this disclosure provides a device and method to exclude cells in selected areas during cell seeding and create cell-free arrays that can be used for cell migration and related studies and assays.

Abstract: A system and method for GPCR signaling pathway analysis and elucidation using a biosensor, a live-cell, and a pathway active compound, as defined herein.

Abstract: Disclosed are compounds having structural formula (I, II) or a pharmaceutically acceptable sale, solvate, clathrate, or prodrug thereof, wherein R1, R2, R3, R6, R5, and R4 are defined herein. These compounds can be useful as therapeutic agents for modulating hERG ion channels, and for improving prevention and treatment of hERG associated cardiac repolarization disorders.

Abstract: An optical sensor for label-independent detection, having improved spatial resolution and reduced angular sensitivity, the sensor including: a substrate; a waveguide grating adjacent the substrate; and a waveguide coat layer adjacent or over the waveguide grating, the waveguide coat layer having a thickness (W) of from 30 nm to 300 nm, the waveguide grating having a teeth height (H) of from 0.2×W to 1×W, and for example, a waveguide core thickness (Wcore=W?H) from 5 nm to 50 nm. Also disclosed is a well-plate article, a well-plate reader system, and methods of using the well-plate and sensor articles, as defined herein.

Abstract: Disclosed are compositions and methods related to identification of modulators of EGFR and VEGFR.

Abstract: A method and apparatus, as defined herein, for use in compound screening, compound profiling, or both assays, for example, against two different cellular targets in, for example, a single cell-type.

Abstract: Disclosed are methods to characterize PI3K inhibitors and Rho kinase inhibitors using label-free cellular assays. Disclosed are also methods to characterize a cell whether it has a deregulated PI3K pathway or not.