Abstract: The present strains and methods of the disclosure relate to genetic modifications in filamentous fungi that give rise to variant strains having altered phenotypes, altered morphologies, altered growth characteristics, and the like. More specifically, as presented and described herein, such variant strains of filamentous fungi comprising reduced viscosity phenotypes are well-suited for growth in submerged cultures (e.g., for the large-scale production of enzymes and other proteins or metabolites for commercial applications).

Abstract: Glycan-binding proteins, and compositions thereof, are generally described, including methods of making and using such proteins. The proteins may include scaffolds based on easily evolvable DNA-binding proteins, with binding sites able to specifically bind to mono- or disaccharides, such as monosaccharide-binding determinants, disaccharide-binding determinants, more complex carbohydrates, etc. In certain aspects, a protein may be generated starting from a small DNA-binding protein, such as Sso7d. Such glycan-binding proteins may have numerous applications, including in enzyme-linked immunosorbent assays (ELISAs), glycan characterization, cell selection, flow cytometry, histology, imaging, arrays, affinity purification, enzyme-linked visualization, binding to a target for pharmaceutical purposes, etc.

Abstract: The present disclosure is generally related to modified filamentous fungal strains (cells) comprising enhanced protein productivity phenotypes, wherein such modified strains are particularly well-suited for growth in submerged cultures (e.g., large-scale production of proteins for industrial/commercial applications). Thus, certain embodiments of the disclosure are related to such variant (modified) strains of filamentous fungus derived (obtained) from parental strains comprising a gene encoding a native GEF1 protein, wherein the variant strain comprises a genetic modification which disrupts or deletes a gene encoding a native GEF1 protein, wherein the variant strain comprises an increased protein productivity phenotype (i.e., relative to the parental strain) when grown/cultivated/fermented under the same conditions.

Abstract: Glycan-binding proteins, and compositions thereof, are generally described, including methods of making and using such proteins. The proteins may include scaffolds based on easily evolvable DNA-binding proteins, with binding sites able to specifically bind to mono- or disaccharides, such as monosaccharide-binding determinants, disaccharide-binding determinants, more complex carbohydrates, etc. In certain aspects, a protein may be generated starting from a small DNA-binding protein, such as Sso7d. Such glycan-binding proteins may have numerous applications, including in enzyme-linked immunosorbent assays (ELISAs), glycan characterization, cell selection, flow cytometry, histology, imaging, arrays, affinity purification, enzyme-linked visualization, binding to a target for pharmaceutical purposes, etc.

Abstract: Embodiments of a razor for shaving are disclosed. The razor may include a water-resistant handle. The razor may also include a blade with at least one sharp edge and one edge substantially enclosed substantially by handle. The razor may also include a blade with a plurality of edges that are interchangeable and each edge of blade may vary in sharpness.

Abstract: Glycan-binding proteins, and compositions thereof, are generally described, including methods of making and using such proteins. The proteins may include scaffolds based on easily evolvable DNA-binding proteins, with binding sites able to specifically bind to mono- or disaccharides, such as monosaccharide-binding determinants, disaccharide-binding determinants, more complex carbohydrates, etc. In certain aspects, a protein may be generated starting from a small DNA-binding protein, such as Sso7d. Such glycan-binding proteins may have numerous applications, including in enzyme-linked immunosorbent assays (ELISAs), glycan characterization, cell selection, flow cytometry, histology, imaging, arrays, affinity purification, enzyme-linked visualization, binding to a target for pharmaceutical purposes, etc.

Abstract: Embodiments of a razor for shaving are disclosed. The razor may include a water-resistant handle. The razor may also include a blade with at least one sharp edge and one edge substantially enclosed substantially by handle. The razor may also include a blade with a plurality of edges that are interchangeable and each edge of blade may vary in sharpness.

Abstract: Systems and methods are provided for assessing competency of a health-care professional using a linear-narrative progression. The system includes a virtual console and an assessment tool. The virtual console is configured to present a clinical vignette to the health-care professional and display a series of digital images and questions to the health-care professional based on the clinical vignette. The virtual console is further configured to receive a response to each of the questions. The virtual console is also configured to display corrective instructions to the health-care professional after receiving a response to critical questions, wherein subsequent digital images and questions are based on the corrective instructions. The assessment tool is configured to assess the health-care professional's interpretation of each of the plurality of digital images.

Abstract: A dynamically rigged load distributing system for an equestrian saddle including several load-bearing sections positioned upon flexible inner side panels to be incorporated in the saddle. Several line guides are fixed respectively to the sections. One or more load distribution lines pass through the guides, and loop around free-running pulleys of the stirrup hanger system. A new stirrup hanger bat includes cliverter pulleys and cooperates with a pulley block to transfer loads through the load-distribution lines to the load-bearing sections around the saddle. A girthing system for the saddle includes webbing attached to the sections so as to depend therefrom and receive ends of girth straps whereby load is transferred to the sections on each side of the saddle.

Abstract: A tray and storage containers combination includes a tray having a bottom, side walls and an open top configured to receive a lid. A plurality of containers are configured to be arranged within the tray, each of which having a top wall and a bottom wall, two side walls and a back wall, each of the plurality of the containers having an openable lid. The containers are positioned in the tray to rest on their respective bottom walls so that the lids of the plurality of the containers face a side wall of the tray.

Abstract: A tray and storage containers combination includes a tray having a bottom, side walls and an open top configured to receive a lid. A plurality of containers are configured to be arranged within the tray, each of which having a top wall and a bottom wall, two side walls and a back wall, each of the plurality of the containers having an openable lid. The containers are positioned in the tray to rest on their respective bottom walls so that the lids of the plurality of the containers face a side wall of the tray.

Abstract: A dynamically rigged load distributing system (1) for an equestrian saddle includes several load-bearing sections (2) positioned upon flexible inner side panels (3) to be incorporated in the saddle. Several line guides (6) are fixed respectively to the sections (2). One or more load distribution lines (7, 8) pass through the guides, and loop around free-running pulleys of the stirrup hanger system. A new stirrup hanger bar (9) includes diverter pulleys (14, 15) and cooperates with a pulley block (11) to transfer loads through the load-distribution lines to the load-bearing sections around the saddle. A girthing system for the saddle includes webbing (16, 17, 18) attached to the sections (2) so as to depend therefrom and receive ends of girth straps (23, 24) whereby load is transferred to the sections (2) on each side of the saddle.

Abstract: A microprocessor-based video and audio data recorder configured to store vehicular related data arising from a vehicular accident or incident in a format retrievable from the device.

Abstract: The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.

Abstract: The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.

Abstract: Niacin in the form of a topical preparation, both as such and when incorporated in devices for application to the skin; the devices themselves; diagnosis or monitoring of schizophrenia using the preparations or devices; and manufacture of medicaments for such monitoring and diagnosis.

Abstract: ‘Eastman’ is a new variety of apple tree discovered as a chance seedling. The fruit of ‘Eastman’ is notable for its attractive tri-color flesh.