Patents by Inventor Elizabeth Werner

Elizabeth Werner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bimolecular optical probes
    Patent number: 7619059
    Abstract: Compositions, methods, and kits for detecting and monitoring post-translational modification activities, including kinase or phosphatase activities, are described. The compositions typically include a peptide, a first detectable moiety, a first binding member, and a protease cleavage site. Modification of a composition by a post-translational modification enzyme, such as a kinase or phosphatase, alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition when it is associated noncovalently with a probe composition that includes a second binding member and a second detectable moiety. Panel assays for determining substrates or modulators of enzymatic activities are also described.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: November 17, 2009
    Assignee: Life Technologies Corporation
    Inventors: Kevin R. Kupcho, Kurt Vogel, Elizabeth A. Werner, Jane A. Beebe, Tony A. Klink, David A. Lasky, Karen M. Kleman-Leyer, Richard Somberg
  • Kinase and phosphatase assays
    Patent number: 7582461
    Abstract: Compositions, methods, and kits for detecting and monitoring kinase or phosphatase activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase or phosphatase alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase or phosphatase activity are also described.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: September 1, 2009
    Assignee: Life Technologies Corporation
    Inventors: Elizabeth A. Werner, Tony A. Klink, Jane A. Beebe, David A. Lasky, Karen M. Kleman-Leyer, Richard Somberg
  • Bimolecular optical probes
    Publication number: 20050170442
    Abstract: Compositions, methods, and kits for detecting and monitoring post-translational modification activities, including kinase or phosphatase activities, are described. The compositions typically include a peptide, a first detectable moiety, a first binding member, and a protease cleavage site. Modification of a composition by a post-translational modification enzyme, such as a kinase or phosphatase, alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition when it is associated noncovalently with a probe composition that includes a second binding member and a second detectable moiety. Panel assays for determining substrates or modulators of enzymatic activities are also described.
    Type: Application
    Filed: September 9, 2004
    Publication date: August 4, 2005
    Inventors: Kevin Kupcho, Kurt Vogel, Elizabeth Werner, Jane Beebe, Tony Klink, David Lasky, Karen Kleman-Leyer, Richard Somberg
  • Kinase and phosphatase assays
    Publication number: 20050054573
    Abstract: Compositions, methods, and kits for detecting and monitoring kinase or phosphatase activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase or phosphatase alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase or phosphatase activity are also described.
    Type: Application
    Filed: July 29, 2004
    Publication date: March 10, 2005
    Inventors: Elizabeth Werner, Tony Klink, Jane Beebe, David Lasky, Karen Kleman-Leyer, Richard Somberg