Abstract: Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.

Abstract: Various embodiments of a system and method for a smart work zone are described. In one example, the system includes smart cone devices configured to transmit smart cone device localization data, a wearable device comprising a processor configured to transmit worker localization data of a worker wearing the garment device and to receive an alert, and a base station. The base station includes an internal edge computing system configured to process the smart cone device localization data to define a virtual geofence boundary of a safe area, process the worker localization data, broadcast a location of the worker wearing the wearable device, and in response to a vehicle or the worker approaching the virtual geofence boundary, provide an alert to at least one of: the worker wearing the wearable device, a passing motorist, or a connected and automated vehicle (CAV).

Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

Abstract: A valve includes a body including an inner bore extending between a first port and a second port, a seat, and one or more restrainers and a disk that is moveable between the seat and the one or more restrainers such that a first pressure that is less than 1 pascal and applied in a first direction causes the disk to move from a first position towards a second position to permit fluid communication between the first port and the second port. A metamaterial scaffold including a structure defining a lumen, at least a portion of an outer or non-lumen surface of the structure is coated with a plurality of biological cells, and wherein the structure is composed of a metamaterial.

Abstract: A beverage dispensing system is disclosed that includes a container assembly configured to store two liquids (e.g., liquor and a mixer) that is couplable to a head assembly. The head assembly includes one or more pumps configured to draw the different liquids from the assembly, to mix variable ratios of the two liquids together, and to dispense the drink. In some configurations, the drink may be dispensed from the beverage dispenser into a glass or directly to the mouth of an individual.

Abstract: An apparatus such as a fluid mixer, suitable for use with a respirator, including a venturi nozzle for flow of a pressure-controlled fluid; an ambient fluid aperture in fluid communication with the venturi nozzle; a fluid port; a pressure force multiplier in fluid communication with the fluid port; and a valve moveable relative to the venturi nozzle between a start flow position and a stop flow position; where the pressure force multiplier is configured such that fluid forced into the fluid port actuates the valve relative to the venturi nozzle; and where the pressure force multiplier is configured such that fluid withdrawn from the fluid port actuates the valve relative to the venturi nozzle, further comprising an active filter that comprises an energy harvesting system and at least one filter medium, wherein the energy harvesting system generates electricity to induce a static charge in the at least one filter medium.

Abstract: A beverage dispensing system is disclosed that includes a container assembly configured to store two liquids (e.g., liquor and a mixer) that is couplable to a head assembly. The head assembly includes one or more pumps configured to draw the different liquids from the assembly, to mix variable ratios of the two liquids together, and to dispense the drink. In some configurations, the drink may be dispensed from the beverage dispenser into a glass or directly to the mouth of an individual.

Abstract: An apparatus such as a fluid mixer, suitable for use with a respirator, including a venturi nozzle for flow of a pressure-controlled fluid; an ambient fluid aperture in fluid communication with the venturi nozzle; a fluid port; a pressure force multiplier in fluid communication with the fluid port; and a valve moveable relative to the venturi nozzle between a start flow position and a stop flow position; where the pressure force multiplier is configured such that fluid forced into the fluid port actuates the valve relative to the venturi nozzle; and where the pressure force multiplier is configured such that fluid withdrawn from the fluid port actuates the valve relative to the venturi nozzle, further comprising an active filter that comprises an energy harvesting system and at least one filter medium, wherein the energy harvesting system generates electricity to induce a static charge in the at least one filter medium.

Abstract: A valve includes a body including an inner bore extending between a first port and a second port, a seat, and one or more restrainers and a disk that is moveable between the seat and the one or more restrainers such that a first pressure that is less than 1 pascal and applied in a first direction causes the disk to move from a first position towards a second position to permit fluid communication between the first port and the second port. A metamaterial scaffold including a structure defining a lumen, at least a portion of an outer or non-lumen surface of the structure is coated with a plurality of biological cells, and wherein the structure is composed of a metamaterial.

Abstract: A valve includes a body including an inner bore extending between a first port and a second port, a seat, and one or more restrainers and a disk that is moveable between the seat and the one or more restrainers such that a first pressure that is less than 1 pascal and applied in a first direction causes the disk to move from a first position towards a second position to permit fluid communication between the first port and the second port. A metamaterial scaffold including a structure defining a lumen, at least a portion of an outer or non-lumen surface of the structure is coated with a plurality of biological cells, and wherein the structure is composed of a metamaterial.

Abstract: A valve includes a body including an inner bore extending between a first port and a second port, a seat, and one or more restrainers and a disk that is moveable between the seat and the one or more restrainers such that a first pressure that is less than 1 pascal and applied in a first direction causes the disk to move from a first position towards a second position to permit fluid communication between the first port and the second port. A metamaterial scaffold including a structure defining a lumen, at least a portion of an outer or non-lumen surface of the structure is coated with a plurality of biological cells, and wherein the structure is composed of a metamaterial.

Abstract: A training mannequin has a multiplicity of sensors mounted in a removable covering to measure the efficacy of a specific attack in a localized region, and informs the user of the effects of that attack in terms of the physiological damage it would cause if the attack were inflicted on a typical human.

Abstract: One possible embodiment could be a composition for coffee ground-based fuel comprising: dried, spent coffee grounds by 54% by weight; vegetable shortening by 23% by weight; brown sugar by 20% by weight; and corn syrup by 2% by weight, wherein the vegetable shortening and brown sugar and mixed together and heated slowly until a boil is achieved, then removing resultant mixture from heat, mixing in dried, spent coffee grounds into resultant mixture, then mixing in corn syrup into the resultant mixture, pouring and pressing the resultant mixture into a selected form for final shaping, then when the mixture has cooled to room temperature, removing it from the form for use.

Abstract: A patient positioning apparatus comprising a base, a support column, at least one positioning arm on the support column capable of being positioned over a bed and having a buckle and strap capable of securing to a patient support with a receiving buckle so that a patient can be partially or totally suspended when an adjustable bed is lowered. The apparatus further comprising a telescoping support column and horizontal support for holding a first and second positioning arm. The positioning arms further comprising locking pivots for extending and retracting. Patient repositioning is effectuated by positioning the arms over a patient, extending straps with buckle inserts into receiving buckles on a fabric gripper secured to bed linens. A patient positioning apparatus can further be mounted to either a ceiling or a wall or can comprise a swiveling support column.

Abstract: Methods and corresponding systems are provided for exercising employee stock options between an employee and a company. The stock option exercise generally includes the steps of establishing a plurality of escrow accounts including a company escrow account, a third party escrow account, and an employee escrow account, receiving notice of intent to exercise a stock option from an employee, transferring securities to satisfy the stock option exercise from the company to a company escrow account, transferring property equivalent to a third party purchase price from a third party to the third party escrow account, transferring the notice of intent to exercise a stock option to the employee escrow account, and transferring property held in the plurality of escrow accounts to the employee, the company, and the third party in accordance at least in part with the stock option.

Abstract: An inventory management system manages information related to items, such as implants, used during a medical surgical procedure. The inventory management system includes an inventory management computer and an item inventory database. The inventory management computer executes an inventory management application to process item usage information. The item usage information includes item identification information and quantity information for each item used during performance of the medical surgical procedure. The inventory management application associates the item usage information with a particular surgical case at a particular customer surgical facility. The inventory management computer receives the item usage information from a customer computer at the customer surgical facility via a wide area network, such as the Internet.

Abstract: One possible embodiment could be a composition for coffee ground-based fuel comprising: dried, spent coffee grounds by 54% by weight; vegetable shortening by 23% by weight; brown sugar by 20% by weight; and corn syrup by 2% by weight, wherein the vegetable shortening and brown sugar and mixed together and heated slowly until a boil is achieved, then removing resultant mixture from heat, mixing in dried, spent coffee grounds into resultant mixture, then mixing in corn syrup into the resultant mixture, pouring and pressing the resultant mixture into a selected form for final shaping, then when the mixture has cooled to room temperature, removing it from the form for use.

Abstract: A mat device for receiving dough to be rolled out and reducing the mess usually associated with rolling out of the dough includes a sheet including a top surface and a bottom surface. The bottom surface is positioned on a support surface. The sheet has a folding line extending along a width of the sheet and bisecting the sheet into a first section and a second section. The folding line facilitates folding of the second section with respect to the first section. An adhesive is coupled to the bottom surface of the first section of the sheet. The adhesive releasably adheres the first section to the support surface when the first section is placed on the support surface.