Patents by Inventor Elizaveta Bonch-Osmolovskaya

Elizaveta Bonch-Osmolovskaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thermostable nucleic acid polymerase from
    Patent number: 8008054
    Abstract: A purified thermostable enzyme is derived form the thermophilic archaebacterium Thermococcus gorgonarius. The enzyme can be native or recombinant, retains approximately 90% of its activity after incubation for two hours at 95° C. in the presence of stabilizing agents and possesses 3?-5? proofreading exonuclease activity. Thermostable DNA polymerases are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: August 30, 2011
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Waltraud Ankenbauer, Vitaly Svetlichny, Elizaveta Bonch-Osmolovskaya, Christine Ebenbichler, Bernhard Angerer, Gudrun Schmitz-Agheguian, Frank Laue
  • Thermostable Nucleic Acid Polymerase From Thermococcus Gorgonarius
    Publication number: 20110020898
    Abstract: A purified thermostable enzyme is derived form the thermophilic archaebacterium Thermococcus gorgonarius. The enzyme can be native or recombinant, retains approximately 90% of its activity after incubation for two hours at 95° C. in the presence of stabilizing agents and possesses 3?-5? proofreading exonuclease activity. Thermostable DNA polymerases are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).
    Type: Application
    Filed: June 3, 2010
    Publication date: January 27, 2011
    Applicant: Roche Diagnostics GmBH
    Inventors: Waltraud ANKENBAUER, Vitaly Svetlichny, Elizaveta Bonch-Osmolovskaya, Christine Ebenbichler, Bernhard Angerer, Gudrun Schmitz-Agheguian, Frank Laue
  • Thermostable nucleic acid polymerase from
    Patent number: 7759107
    Abstract: A purified thermostable enzyme is derived form the thermophilic archaebacterium Thermococcus gorgonarius. The enzyme can be native or recombinant, retains approximately 90% of its activity after incubation for two hours at 95° C. in the presence of stabilizing agents and possesses 3?-5? proofreading exonuclease activity. Thermostable DNA polymerases are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: July 20, 2010
    Assignee: Roche Diagnostics GmbH
    Inventors: Waltraud Ankenbauer, Vitaly Svetlichny, Elizaveta Bonch-Osmolovskaya, Christine Ebenbichler, Bernhard Angerer, Gudrun Schmitz-Agheguian, Frank Laue
  • THERMOSTABLE NUCLEIC ACID POLYMERASE FROM THERMOCOCCUS GORGONARIUS
    Publication number: 20090093043
    Abstract: A purified thermostable enzyme is derived form the thermophilic archaebacterium Thermococcus gorgonarius. The enzyme can be native or recombinant, retains approximately 90% of its activity after incubation for two hours at 95° C. in the presence of stabilizing agents and possesses 3?-5? proofreading exonuclease activity. Thermostable DNA polymerases are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).
    Type: Application
    Filed: June 9, 2008
    Publication date: April 9, 2009
    Applicant: Roche Diagnostics GmBH
    Inventors: Waltraud Ankenbauer, Vitaly Svetlichny, Elizaveta Bonch-Osmolovskaya, Christine Ebenbichler, Bernhard Angerer, Gudrun Schmitz-Agheguian, Frank Laue
  • Thermostable nucleic acid polymerase from
    Patent number: 7425423
    Abstract: A purified thermostable enzyme is derived from the thermophilic archaebacterium Thermococcus gorgonarius. The enzyme can be native or recombinant, retains approximately 90% of its activity after incubation for two hours at 95° C. in the presence of stabilizing agents and possesses 3?-5? proofreading exonuclease activity. Thermostable DNA polymerases are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).
    Type: Grant
    Filed: October 1, 1997
    Date of Patent: September 16, 2008
    Assignee: Roche Diagnostics GmbH
    Inventors: Waltraud Ankenbauer, Vitaly Svetlichny, Elizaveta Bonch-Osmolovskaya, Christine Ebenbichler, Bernhard Angerer, Gudrun Schmitz-Agheguian, Frank Laue
  • Thermostable DNA polymerase from anaerocellum thermophilum
    Publication number: 20050019789
    Abstract: A thermostable enzyme is provided which is derived from the microorganism Anaerocellum thermophilum. The enzyme has a molecular weight of 96 to 100 kDa, shows DNA polymerase activity and reverse transcriptase activity in the presence of magnesium ions. The enzyme may be native or recombinant, and may be used with selected primers and nucleoside triphosphates in a temperature cycling polymerase chain reaction on DNA or RNA as template with or without additional DNA polymerases as an enzyme mixture.
    Type: Application
    Filed: February 2, 2004
    Publication date: January 27, 2005
    Applicant: Roche Diagnostics GMBH
    Inventors: Waltraud Ankenbauer, Gudrun Schmitz-Agheguian, Elizaveta Bonch-Osmolovskaya, Vitaly Svetlichny, Ursula Markau, Bernhard Angerer, Astrid Reiser
  • Thermostable DNA polymerase from anaerocellum thermophilum
    Patent number: 6692932
    Abstract: A thermostable enzyme is provided which is derived from the microorganism Anaerocellum thermophiluml. The enzyme has a molecular weight of 96 to 100 kDa, shows DNA polymerase activity and reverse transcriptase activity in the presence of magnesium ions. The enzyme may be native or recombinant, and may be used with selected primers and nucleoside triphosphates in a temperature cycling polymerase chain reaction on DNA or RNA as template with or without additional DNA polymerases as an enzyme mixture.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: February 17, 2004
    Inventors: Waltraud Ankenbauer, Gudrun Schmitz-Agheguian, Elizaveta Bonch-Osmolovskaya, Vitaly Svetlichny, Ursula Markau, Bernhard Angerer, Astrid Reiser
  • Thermostable DNA polymerase from carboxydothermus hydrogenoformans
    Patent number: 6468775
    Abstract: A DNA polymerase from a thermophilic eubacterium is provided. The DNA polymerase shows magnesium ion dependent reverse transcriptase activity and 3′-5′ exonuclease activity. The invention also includes recombinant plasmids and transformed host cells capable of producing the enzyme. The enzyme is classified into class EC 2.7.7.7., a DNA nucleotidyl transferase DNA-directed type.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: October 22, 2002
    Assignee: Roche Molecular Systems Inc.
    Inventors: Waltraud Ankenbauer, Ursula Markau, Vitaly Svetlichny, Gudrun Schmitz-Agheguian, Astrid Reiser, Bernhard Angerer, Christine Ebenbichler, Frank Laue, Elizaveta Bonch-Osmolovskaya