Patents by Inventor Ella Zeldich

Ella Zeldich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11807850
    Abstract: The present disclosure relates to compositions and methods for modulating gene expression and in particular to compositions and methods for increasing expression of Klotho. For example, the present disclosure provides methods for increasing expression of a Klotho gene in a human cell comprising introducing into the cell a CRISPR enzyme and a guide RNA comprising a guide sequence that is substantially complementary to a target sequence within or near the Klotho gene, wherein the guide RNA or the CRISPR enzyme associates with a transcriptional activation domain.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: November 7, 2023
    Assignee: KLOGENIX LLC
    Inventors: Ci-Di Chen, Ella Zeldich, Carmela Abraham
  • Publication number: 20230101807
    Abstract: The present disclosure relates to compositions and methods for modulating gene expression and in particular to compositions and methods for increasing expression of Klotho. In certain examples, the present disclosure provides a method of increasing expression of a Klotho gene in a cell the method comprising administering to the cell a binding molecule that binds to an RNA transcript transcribed from a chromosomal region within or near the Klotho gene, wherein the RNA transcript does not encode a Klotho protein.
    Type: Application
    Filed: September 6, 2019
    Publication date: March 30, 2023
    Inventors: Ci-Di Chen, Ella Zeldich, Carmela Abraham
  • Publication number: 20210171944
    Abstract: The present disclosure relates to compositions and methods for modulating gene expression and in particular to compositions and methods for increasing expression of Klotho. For example, the present disclosure provides methods for increasing expression of a Klotho gene in a human cell comprising introducing into the cell a CRISPR enzyme and a guide RNA comprising a guide sequence that is substantially complementary to a target sequence within or near the Klotho gene, wherein the guide RNA or the CRISPR enzyme associates with a transcriptional activation domain.
    Type: Application
    Filed: December 4, 2018
    Publication date: June 10, 2021
    Inventors: Ci-Di Chen, Ella Zeldich, Carmela Abraham