Abstract: The present disclosure relates to IL10 agonists with improved anti-tumor therapeutic efficacy and uses thereof. Certain IL10 agonists disclosed herein comprise an IgG Fc domain, a linker moiety, and an IL10 moiety.

Abstract: A first intent from customer provided data is encoded as an intent embedding and the intent embedding of the first intent and an intent embedding corresponding to one or more items of a training workspace are compared to generate a similarity score. The first intent is mapped to a similar item of the one or more items and a corresponding count of the similar item is incremented by one in response to the similarity score being greater than a given threshold. A matrix is created based on the similarity score. At least a first machine learning model is trained using one or more of the training workspaces of the created matrix; at least a second machine learning model is trained using the created matrix; and deployment of the at least second machine learning model is facilitated for performing inferencing.

Abstract: Technology is disclosed herein for an application for generating and auto-tuning reading passages. A method of operating an application includes generating a prompt which elicits a reply from a foundation model service that includes a reading passage tailored to the ability of a reader. The prompt includes instructions for generating the reading passage using one or more trouble words and according to a desired readability. The desired readability is based on one or more indicators of a reader's reading ability. The application assesses the readability of the reading passage, resulting in an assessed readability. The application generates a follow-on prompts with which to elicit follow-on replies from the foundation model service that includes a request to adjust the reading passage based on the assessed reliability. The application enables display of the adjusted reading passage in a user interface of the application.

Abstract: The present disclosure relates to a fiber material having an antimicrobial effect, comprising fibers of regenerated cellulose and/or regenerated cellulose derivatives and at least one antimicrobial agent component. The present disclosure also includes a method of producing a fiber material having an antimicrobial effect, a fiber material produced by the method, and the use of the fiber material. The agent component of the fiber material comprises silver (Ag) and ruthenium (Ru), wherein silver and ruthenium are in electrical contact with one another and embedded in and/or at least partially surrounded by the cellulose and/or cellulose derivative fibers. The fiber material has not only antimicrobial properties, but also deodorising and/or odor-neutralising properties. In particular, the durability of the efficacy of the hygiene fibers is surprising.

Abstract: An apparatus for delivering a flow of gas has a housing, a cover, and a magnetic coupling system arranged to magnetically couple the cover—to the housing. Each of the housing and cover having complementary locating features, the locating features being adapted to locate and align the cover and the apparatus relative to each other to allow for the magnetic coupling. The apparatus also has a handle movably connected to the housing and is movable from a first position to a second position. The housing and the handle comprise complementary interlock features arranged to engage with each other when upward force is applied to the handle in the second position, and the interlock features are disengaged from each other when the handle is in the second position but upward force is not applied to the handle.

Abstract: The invention relates to a method and a computer program for automatic shape quantification of an optic nerve head from three-dimensional image data (1) acquired with optical coherence tomography, comprising the steps of: a) Providing (100) three-dimensional image data (1) of the retina, the image data comprising at least a portion of the optic nerve head, wherein the image data comprises pixels with associated pixel values; b) In the three-dimensional image data (1) identifying (200, 300) anatomic portions of the optic nerve head, the anatomic portions comprising a retinal pigment epithelium (RPE) portion (3) and an inner limiting membrane (ILM) portion (2); c) Determining an RPE polygon mesh (30) for a lower boundary of the retinal pigment epithelium portion (3), wherein the RPE polygon mesh (30) extends along the lower boundary of the retinal pigment epithelium portion (3); d) Determining an ILM polygon mesh (20) for the inner limiting membrane portion (2), wherein the ILM polygon mesh (20) extends alon

Abstract: A feedback controller is provided to generate a quantum feedback operation to control one or more ancilla qubits in a quantum error correcting code. The quantum feedback operation is based on the measurement of the one or more ancilla qubits. The feedback controller is operable to dynamically adjust a state discrimination according to previous measurements of the one or more ancilla qubits.

Abstract: The invention discloses vaccine for coronavirus and influenza virus and method for preparation thereof. More specifically, the invention discloses seasonal viral vaccine i. e. coronavirus and influenza virus vaccine for prophylaxis of novel coronavirus (SARS-CoV-2) infection (COVID-19) and Influenza virus in mammals and method for preparation of such vaccine. The invention discloses the stable combination vaccine compositions of killed-inactivated SARS-CoV-2, Influenza virus (A and B strains) as antigens. The present invention further discloses method of adaptation and growth seasonal influenza (A and B) strains in cell culture and methods of inactivation and purification of influenza virus bulk antigen. The present invention also discloses SARS-CoV-2 vaccine formulation with inactivated Influenza viruses and use of the same to elicit immune response against the SARS-CoV-2 and Influenza viruses in mammals and humans.

Abstract: Embodiments described herein include portable devices having user-detection equipment, such as eye-tracker devices or other sensors, and computer systems including such portable devices or the data collected from such devices (such as eye-tracking data and/or other multi-modal data such as facial expressions, verbal expression, and/or physical movements). Some examples of the systems include can provide useful assessments for developmental disorders and can generate prescriptive treatment plans having individual time lengths for different treatment-specific skill areas during a period of time.

Abstract: Systems and methods are provided herein for operating an insights service. For example, a method of operating an insights service includes observing, on a per-user basis with respect to each user in a group of observed users, the prompting associated with a large language model service, identifying, on the per-user basis with respect to each of the group of observed users, insights into the prompting, and enabling display of the insights in a user interface associated with a reviewing user.

Abstract: Preliminary frames are selected from a video segment. For each preliminary frame, an emotion present in the preliminary frame and an emotional intensity of the emotion present in the preliminary frame are identified using a machine learning model. One or more candidate frames are selected from the preliminary frames having the emotion that is present in the greatest number of the preliminary frames. One or more representative frames for the video segment are selected from the candidate frames based on the emotional intensity thereof.

Abstract: The disclosure is directed to methods of treating depression in a human patient in need thereof, whereby certain patients may be qualified for a reduced monitoring period after a treatment session. The methods are based on an analysis of adverse events and provide treatment options for the patient and healthcare provider.

Abstract: Retinal optical coherence tomography (OCT) with intraretinal layer segmentation is increasingly used not only in ophthalmology but also for neurological diseases such as multiple sclerosis (MS). Signal quality influences segmentation results, and high-quality OCT images are needed for accurate segmentation and quantification of subtle intraretinal layer changes. Among others, OCT image quality depends on the ability to focus, patient compliance and operator skills. Current criteria, for OCT quality define acceptable image quality, but depend on manual rating by experienced graders and are time consuming and subjective. In this paper, we propose and validate a standardized, grader-independent, real-time feedback system for automatic quality assessment of retinal OCT images. We defined image quality criteria for scan centering, signal quality and image completeness based on published quality criteria and typical artifacts identified by experienced graders when inspecting OCT images.

Abstract: Systems and methods for visual cue based messaging. A visual cue module can provide visual cue data indicative of a visual cue assigned for a contact or a group of contacts from a contact list. A messenger module can output on a display a messenger application GUI. The messenger application GUI includes a message field, a message window with a message thread between a user and the contact or the group of contacts, and a virtual keyboard. The messenger module can output the messenger application GUI with a visual cue graphical element representative of the visual cue to provide a visual indication of the contact or the group of contacts on the display to the user based on the visual cue data. The visual cue can be associated with the messaging field, the message thread, or at least one virtual key of the virtual keyboard.

Abstract: A method, computer system, and a computer program product for automated agent intent detection enhancement are provided. A first message from a first user is received. The first message is generated during a first conversation between the first user and a first automated agent. A computer produces a second message that includes a same request as the first message but a different language modality than the first message. The second message and the first message are combined to form a combined message. The combined message is input into the first automated agent such that the first automated agent produces an intent classification for the first message.

Abstract: The disclosure pertains to a harness for battery-powered personal flying apparatus. The harness comprises a pair torso struts hingedly coupled to a pair of leg braces which allow the legs to move independently of each other. The harness further includes extension rods coupled at a first end to the torso struts. The extension rods are coupled at a second end thereof to skis. The extension rods and skis being moveable between a standing position and an in-flight position. Said extension rods and skis configured to allow the harness to be independently supported in such a way that a user could step into or out of the harness from a generally upright position.

Abstract: The present disclosure relates to compositions and methods for modulating gene expression and in particular to compositions and methods for increasing expression of Klotho. In certain examples, the present disclosure provides a method of increasing expression of a Klotho gene in a cell the method comprising administering to the cell a binding molecule that binds to an RNA transcript transcribed from a chromosomal region within or near the Klotho gene, wherein the RNA transcript does not encode a Klotho protein.

Abstract: The invention is directed to Muramyl Dipeptide (MDP) derivative compounds of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof: wherein, R can be a linear or branched alkyl, an aryl, a substituted aryl, or an alkoxy alkyl. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are particularly useful as adjuvants in vaccines.

Abstract: A functionalized electrode capable of selectively interacting with a viral biomarker, an electrochemical system comprising the electrode and methods utilizing same for, for example, determining a presence of a viral infection in a subject are provided.

Abstract: A wound dressing, a method of manufacturing a wound dressing, and a method of treating a patient are disclosed. The wound dressing may include an absorbent layer for absorbing wound exudate; and an obscuring element for at least partially obscuring a view of wound exudate absorbed by the absorbent layer in use.