Abstract: A part assembly (100), comprising: an aluminium part (101); a magnesium part (102), the magnesium part (102) coated in a first coating (104); a bond (103), the bond (103) securing the aluminium part (101) to the coated magnesium part (114); wherein the aluminium part (101), the coated magnesium part (114) and the bond (103) are subjected to an electrophoresis coating process to coat the aluminium part (101) in a second coating (105). By subjecting the aluminium part (101), the coated magnesium part (114) and the bond (103) to an electrophoresis coating process to coat the aluminium part (101) in a second coating (105) this may provide a simpler manufacturing process.

Abstract: Compositions of matter comprising RNA silencing molecules capable of mediating cleavage of p21 mRNA are disclosed. Methods of eradicating senescent cells or cancer cells, as well as methods of treating senescence-associated diseases or disorders, cancer, and fibrotic diseases and disorders are also disclosed.

Abstract: A method is disclosed for manufacturing a fiber-reinforced implant structure. A fiber-reinforced rigid insert is provided, comprising continuous fibers impregnated with a first thermoplastic polymer. A molding cycle is performed by overmolding. The insert is placed into a mold cavity; and a second thermoplastic polymer in melted form is injection or compression molded into the mold cavity. The insert is thus at least partly covered by the second thermoplastic polymer. The second thermoplastic polymer injection or compression in the mold cavity is cooled, thereby obtaining a molded fiber-reinforced implant structure containing the at least partly covered insert. The insert is in a predefined location in the mold cavity during said injection or compression molding and during said cooling. The first thermoplastic polymer and the second thermoplastic polymer are the same or different. Also disclosed is an implant structure, and an implant comprising said implant structure.

Abstract: The present disclosure relates to compositions and methods for modulating gene expression and in particular to compositions and methods for increasing expression of Klotho. For example, the present disclosure provides methods for increasing expression of a Klotho gene in a human cell comprising introducing into the cell a CRISPR enzyme and a guide RNA comprising a guide sequence that is substantially complementary to a target sequence within or near the Klotho gene, wherein the guide RNA or the CRISPR enzyme associates with a transcriptional activation domain.

Abstract: The present invention relates to annotating a medical image. For an improved manual insertion of information in a medical image, it is provided to display an image (130) of a tubular structure; and to display a graphical representation (132) of at least one segmented portion of the tubular structure; wherein the graphical representation comprises at least one indicator line representing the portion's shape and/or extension; and wherein the graphical representation is displayed in combination with the image of the tubular structure; and to generate and display at least one marker (128) overlaid to the image of the tubular structure; wherein the marker is movable (134) along the graphical representation; and to position the marker at a location along the graphical representation to indicate a predetermined feature of the tubular structure.

Abstract: A method for applying bipolar ablation pulses, the method includes positioning multiple electrodes of a catheter in contact with tissue of an organ. The tissue is ablated using the multiple electrodes in accordance with a predefined pattern including a periodic set of time slots. Each of the time slots defines (i) an electrode-pair (EP), (ii) a waveform of one or more bipolar ablation pulses (BAPs) applied to the tissue by the EP, and (iii) a duration of the time slot. The time slots are applied sequentially, and the pattern further includes at least one time slot that is empty.

Abstract: An apparatus is disclosed for bridge filters. In example aspects, the apparatus includes a filter circuit with a current balun and a filter core. The current balun includes a first terminal coupled to a first port of the filter circuit, a second terminal, a third terminal, and a fourth terminal. The current balun also includes a first inductor galvanically coupled between the first terminal and the second terminal. The current balun further includes a second inductor galvanically coupled between the third terminal and the fourth terminal. The filter core is coupled between the current balun and a second port of the filter circuit. The filter core is galvanically coupled to the second terminal of the current balun and to the fourth terminal of the current balun.

Abstract: In one embodiment, a method may access, from one or more data sources associated with a user, customer data associated with a customer of the user, wherein the customer data includes qualitative and quantitative data. The method can generate a plurality of normalized key performance indicators (KPIs) using the customer data and a normalization algorithm. The method can access a customer-health score model, wherein the customer-health score model is trained to determine a customer-health score using the plurality of normalized KPIs. The method can determine, using the customer-health score model, a customer-health score for the customer using the plurality of normalized KPIs. The method can send instructions for presenting a user interface to the user, the user interface comprising information associated with the plurality of normalized KPIs and the customer-health score for the customer.

Abstract: Aspects of the disclosure relate to a method of estimating a length of a queue associated with a resource within a venue. Images of the queue may be received, each image corresponding to a segment of the queue. A server may estimate a number of venue guests in the queue by: for each of a first subset of the images, estimating a number of pixels of the image that correspond to venue guests in the queue; and for each of a second subset of the images, detecting and counting individual venue guests visible in the image. A notification including the estimated number of venue guests in the queue, an estimated current wait time, and/or a time at which a venue guest joining the queue is permitted entry to the resource, may be sent to devices corresponding to venue guests.

Abstract: A fluid infusion system includes a housing configured to be adhesively coupled to an anatomy of a user, and a tube configured to extend from the housing for insertion into the anatomy of the user. The tube includes a plurality of conduits defined within the tube. The plurality of conduits include a fluid delivery conduit configured to facilitate a fluidic connection between a fluid source and the anatomy of the user, and one or more conduits configured to accommodate a plurality of electrodes for determining a physiological characteristic of the user.

Abstract: A location of an occupant within a vehicle and/or an activity engaged in by the occupant may be determined. Based on the location and/or the activity, a point of interest associated with the occupant and/or the vehicle may be determined. One or more systems of the vehicle, such as the steering and/or suspension, may be controlled to minimize acceleration associated with the point of interest, thereby increasing a comfort of the occupant. In instances where the vehicle includes more than one occupant, the vehicle may be adjusted to accommodate the multiple occupants.

Abstract: Technologies are described for methods and systems effective for flex plates. The flex plates may comprise a base plate. The base plate may include walls that define an insert location opening in the base plate. The insert location opening in the base plate may be in communication with a securement area. The flex plates may comprise an insert. The insert may include a reservoir region and a crystallization region separated by a wall including channels. The reservoir region and the crystallization region may include a backing. The insert may further include securement tabs. The securement tabs may be configured to secure the insert to the base plate at the securement area.

Abstract: A method of ablation includes storing in a memory a pre-determined relation between lesion size and amount of ablative energy, for each of one or more selected temperatures. Using a processor, user input is received, that indicates a lesion size and a tissue temperature. Based on the relation, an amount of energy is determined, that matches the lesion size and the tissue temperature. An ablation probe is controlled to apply the amount of ablative energy that matches the selected lesion size.

Abstract: There is provided a blade angle feedback assembly for a propeller of an aircraft engine. The propeller is rotatable about an axis and has propeller blades rotatable about respective spanwise axes to adjust a blade angle thereof. The blade angle feedback assembly comprises a feedback ring having a plurality of position markers disposed thereon, at least one sensor configured to provide feedback on the blade angle of the propeller blades by detecting a relative movement between the feedback ring and the at least one sensor, and at least one shielding element provided between the feedback ring and the propeller, the at least one shielding element configured to shield the feedback ring from electromagnetism.

Abstract: Training a neural network, including applying a quantization function to a set of real-valued weights to generate quantized weights scaled to fall within a respective quantization range that is symmetrically centered at zero and comprises a defined number of uniform quantization levels corresponding to integer multiples of a scaling factor. A cost is computed based alignments of the quantized weights with the quantization levels. The real-valued weights and the scaling factor are adjusted with an objective of reducing the computed cost in one or more following training iterations. When performing a plurality training iterations, a smoothness of the quantization function is incrementally reduced for multiple training iterations. Alignment of quantized weights with quantization levels and decreasing smoothness of the quantization function can result in a trained neural network that can perform accurate predictions using relatively few computational resources.

Abstract: A curable, partially hydrogenated butadiene polymer having a hydrogenation degree from 0.5 to 55% and having a total amount of butadiene-derived vinyl groups according to the general formula (I) and trans groups of the general formula (II) of from 0% to 9% by weight based on the total weight of the polymer and wherein the partially hydrogenated polybutadiene polymer is a butadiene polymer comprising at least 50% by weight based on the total weight of the polymer which is 100%, of units derived from 1,3-butadiene. Also provided are a process to make the polymer, compositions containing the polymer and articles obtained by using the polymer.

Abstract: Methods and systems for testing a sensor of a propeller blade angle position feedback system are described. A sensor signal is received from a sensor at a known position relative to a feedback device, the feedback comprising a ring and at least one pair of position markers spaced from one another around a circumference thereof, the sensor configured for successively detecting passage of the position markers as the feedback device rotates at a known rotational speed and an axial distance between the sensor and the feedback device varies. From the sensor signal a measured position of the sensor relative to the feedback device and a measured rotational speed of the feedback device are determined. The measured position and the measured rotational speed are compared to the known position and the known rotational speed to determine a sensor accuracy.

Abstract: An apparatus is disclosed for a lattice-type filter. In example aspects, the apparatus includes a filter circuit having a first port that is single-ended and a second port that is single-ended. The filter circuit also includes a transformer, a first resonator, a second resonator, a third resonator, and a fourth resonator. The transformer includes a first terminal, a second terminal, and a third terminal, with the third terminal coupled to the second port. The first resonator is coupled between the first port and the first terminal of the transformer. The second resonator is coupled between the first port and the second terminal of the transformer. The third resonator is coupled between the first terminal of the transformer and a ground. The fourth resonator is coupled between the second terminal of the transformer and the ground.

Abstract: A method for automatically assigning seats to a group of persons is provided. The method includes: receiving a first user input that relates to building space availability and a second user input that relates to employer requirements for seat occupancy; determining, based on the first and second user inputs, a building section within which seats are to be assigned to the group; and assigning, to each respective person within the group based on the first and second user inputs, a respective seat within the determined building section and a respective schedule during which the respective seat is to be occupied by the respective person. The assigning may be implemented by applying a machine learning algorithm that is trained by using historical data that relates prior seat occupancies of each respective person with the group.

Abstract: An apparatus is disclosed for a bridge-type filter. In example aspects, the apparatus includes a filter circuit having a first port, a second port, and a filter core. The filter core is coupled between the first port and the second port. The filter core includes at least one transformer, a first resonator arrangement, and a second resonator arrangement. The first resonator arrangement is coupled to the at least one transformer and includes multiple acoustic resonators. The second resonator arrangement is coupled to the at least one transformer and includes multiple acoustic resonators.