Patents by Inventor Ellen Carmichael

Ellen Carmichael has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiviral poly-and oligonucleotides
    Patent number: 5728518
    Abstract: Poly- and oligonucleotides which inhibit viral replication, particularly hepatitis virus replication, such as hepatitis B virus (HBV) replication, are disclosed.
    Type: Grant
    Filed: August 8, 1994
    Date of Patent: March 17, 1998
    Assignee: The Immune Response Corporation
    Inventor: Ellen Carmichael
  • Use of a bacterial component to enhance targeted delivery of polynucleotides to cells
    Patent number: 5728399
    Abstract: An improved soluble molecular complex for targeting a polynucleotide to a specific cell is disclosed. The molecular complex comprises (a) a polynucleotide (b) a carrier made up of a polynucleotide binding agent and a cell-specific binding agent which binds to a surface molecule of the cell and is internalized into an endosome, and (c) a bacterial component or fragment thereof which lyses the endosome and causes the polynucleotide to be released into the cytoplasm of the cell. In a preferred embodiment of the invention the polynucleotide binding agent is polylysine, the cell-specific binding agent is an asialoglycoprotein, and the bacterial component is listeriolysin O. The disclosed soluble molecular complex and methods of use can be used therapeutically to deliver genes and antisense polynucleotides to specific cells in vivo.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 17, 1998
    Assignees: University of Conn., TargeTech, Inc. a wholly owned subsidiary of The Immune Response Corporation
    Inventors: George Y. Wu, Catherine H. Wu, Ying Zhang, George L. Spitalny, Ellen Carmichael