Abstract: An adjustable child seat, including a main seat body to receive a user thereupon, a pivoting dome disposed on at least a portion of a bottom surface of the main seat body, a seat base to removably connect to the pivoting dome, such that the main seat body pivots with respect to the seat base via the pivoting dome, and rotates in response to a rotation of the seat base, and an alarm unit disposed on at least a portion of the seat base, the alarm unit including a tether disposed on at least a portion of the alarm unit to connect to a parent, such that the alarm unit generates an alert in response to the parent exceeding a range of the tether.

Abstract: A method of making a macrocyclic chelator comprising converting Co(II)Cl2 to a stabilized Co(III) complex, reacting the Co(III) complex with a cyclen ligand comprising a carboxylic acid or a methyl benzoic acid moiety through which amine bond formation with a primary amine can be achieved and reacting the Co(III) cyclen carboxylic acid or methyl benzoic acid complex with a suitable modified oligonucleotide to form a sequence-specific gene silencing moiety. A method comprising coordinating a kinetically inert ion to a macrocyclic chelator or ligand, bonding a first functional group, reacting with an oligonucleotide, bonding a second functional group, attaching the first functional group to the second functional group, binding the macrocyclic chelator to a target thus inhibiting translation, wherein the macrocyclic chelator hydrolyzes a photodiester bond.

Abstract: The biosensor comprises a modular biorecognition element and a modular flexible arm element. The biorecognition element and the flexible arm element are each labeled with a signaling element. The flexible arm contains an analog of an analyte of interest that binds with the biorecognition element, bringing the two signaling elements in close proximity, which establishes a baseline fluorescence resonance energy transfer (FRET). When an analyte of interest is provided to the biosensor, the analyte will displace the analyte analog, and with it, the signaling module of the modular flexible arm, causing a measurable change in the FRET signal in a analyte concentration dependent manner. The modularity of different portions of the biosensor allows functional flexibility. The biosensor-operates without additional development reagents, requiring only the presence of analyte or target for function.

Abstract: A composition comprising a kinetically inert ion coordinated to a macrocyclic chelator or ligand, a first functional group bonded to the macrocyclic chelator or ligand, an oligonucleotide, and a second functional group bonded to the oligonucleotide, wherein the first functional group covalently bonds to the second functional group.