Patents by Inventor Ellen HE

Ellen HE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12195553
    Abstract: Disclosed are the development of a recombinant chicken IgY monoclonal antibody and a recombinant chicken IgY single-chain variable fragment (scFv) antibody raised against human thymidine kinase 1 in mammalian cells and a preparation method and use thereof. A light chain of the scFv antibody includes an amino acid sequence shown in SEQ ID NO: 1, and a heavy chain of the scFv antibody includes an amino acid sequence shown in SEQ ID NO: 2.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: January 14, 2025
    Assignee: SINO-SWED TONGKANG BIO-TECH (SHENZHEN) LIMITED
    Inventors: Zuosheng Li, Hu Chen, Huijun Li, Li Dang, Liwen Liang, Cong Fang, Junye Tan, Ellen He, Sven Isac Skog, Ji Zhou
  • Patent number: 12103980
    Abstract: Disclosed are the expression of a recombinant chicken IgY scFv antibody and monoclonal antibody raised against human thymidine kinase 1 (hTK1) in prokaryotic cells and a preparation method and use thereof. The scFv antibody includes an amino acid sequence shown in SEQ ID NO: 1. The anti-hTK1 recombinant scFv antibody and monoclonal antibody have good immunoreactivity, high specificity and sensitivity, and are easy to separate and purify.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: October 1, 2024
    Assignee: SINO-SWED TONGKANG BIO-TECH (SHENZHEN) LIMITED
    Inventors: Hu Chen, Zuosheng Li, Huijun Li, Liwen Liang, Li Dang, Senbo Liu, Cong Fang, Peng Gao, Ellen He, Sven Isac Skog, Ji Zhou
  • Publication number: 20240279286
    Abstract: Specifically disclosed are a core amino acid sequence group capable of target recognizing anti-novel coronavirus neutralizing antibodies N-IgY-pAbs and a use thereof. The core amino acid sequence group capable of target recognizing anti-novel coronavirus neutralizing antibodies N-IgY-pAbs includes 15 types of the amino acid sequences positioned in an S-ECD region and 5 types of the amino acid sequences positioned in a non-structural protein (NSP) region, and can be applied to a detection of the novel coronavirus, a design of therapeutic targets and a design of vaccine targets.
    Type: Application
    Filed: April 16, 2024
    Publication date: August 22, 2024
    Inventors: Ailian HEI, Jin LI, Ellen HE, Sven Isac SKOG, Ji ZHOU
  • Publication number: 20210277147
    Abstract: Disclosed are the development of a recombinant chicken IgY monoclonal antibody and a recombinant chicken IgY single-chain variable fragment (scFv) antibody raised against human thymidine kinase 1 in mammalian cells and a preparation method and use thereof. A light chain of the scFv antibody includes an amino acid sequence shown in SEQ ID NO: 1, and a heavy chain of the scFv antibody includes an amino acid sequence shown in SEQ ID NO: 2.
    Type: Application
    Filed: March 4, 2021
    Publication date: September 9, 2021
    Inventors: Zuosheng LI, Hu CHEN, Huijun LI, Li DANG, Liwen LIANG, Cong FANG, Junye TAN, Ellen HE, Sven Isac SKOG, Ji ZHOU
  • Publication number: 20210189010
    Abstract: Disclosed are the expression of a recombinant chicken IgY scFv antibody and monoclonal antibody raised against human thymidine kinase 1 (hTK1) in prokaryotic cells and a preparation method and use thereof. The scFv antibody includes an amino acid sequence shown in SEQ ID NO: 1. The anti-hTK1 recombinant scFv antibody and monoclonal antibody have good immunoreactivity, high specificity and sensitivity, and are easy to separate and purify.
    Type: Application
    Filed: March 4, 2021
    Publication date: June 24, 2021
    Inventors: Hu CHEN, Zuosheng LI, Huijun LI, Liwen LIANG, Li DANG, Senbo LIU, Cong FANG, Peng GAO, Ellen HE, Sven Isac SKOG, Ji ZHOU
  • Publication number: 20210190780
    Abstract: Disclosed are a kit and use thereof. The kit includes a first polyclonal antibody that has been immobilized or suitable for immobilization on a solid carrier, a second polyclonal antibody labeled with a marker. Both the first polyclonal antibody and the second polyclonal antibody are both chicken anti human-thymidine kinase IgY-polyclonal antibodies. Both the first polyclonal antibody and the second polyclonal antibody are suitable for specifically binding to thymidine kinase 1. The kit is suitable for the risk assessment of micro malignant tumors/precancerous diseases and tumors that are not detectable by human population screening images.
    Type: Application
    Filed: March 3, 2021
    Publication date: June 24, 2021
    Inventors: Li DANG, Liwen LIANG, Zuosheng LI, Huijun LI, Hu CHEN, Cong FANG, Lu CHEN, Ellen HE, Sven Isac SKOG, Ji ZHOU