Patents by Inventor Ellen Klegraf

Ellen Klegraf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparation of acetoacetylated polyols
    Patent number: 11802104
    Abstract: The invention discloses a method for preparation of an acetoacetylated polyol by reaction of a polyol with deketene in the presence of a base and in the absence of a solvent.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: October 31, 2023
    Assignee: ARXADA AG
    Inventors: Masaki Nakajima, Anja Bierstedt, Leo Schmid, Maximilian Kuehnle, Ulrich Mayerhoeffer, Ellen Klegraf
  • Method for Preparation of Acetoacetylated Polyols
    Publication number: 20220185762
    Abstract: The invention discloses a method for preparation of an acetoacetylated polyol by reaction of a polyol with deketene in the presence of a base and in the absence of a solvent.
    Type: Application
    Filed: April 3, 2020
    Publication date: June 16, 2022
    Inventors: Masaki Nakajima, Anja Bierstedt, Leo Schmid, Maximilian Kuehnle, Ulrich Mayerhoeffer, Ellen Klegraf
  • Method for Preparation of Potassium 5-Iodo-2-Carboxybenzene Sulfonate
    Publication number: 20210261501
    Abstract: The invention discloses a method for the preparation of potassium 5-iodo-2-carboxybenzene sulfonate by diazotization of 5-amino-2-carboxybenzene sulfonate and subsequent reaction with KI.
    Type: Application
    Filed: September 24, 2019
    Publication date: August 26, 2021
    Inventors: Ellen KLEGRAF, Patrick SCHANEN, Florencio ZARAGOZA DOERWALD
  • Process for the enzymatic production of carnitine from beta-lactones
    Patent number: 9523106
    Abstract: Subject of the invention is a process for the production of L-carnitine, wherein a ?-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into L-carnitine, wherein the process comprises an enzymatic conversion of the ?-lactone into (R)-4-halo-3-hydroxybutyric acid or (R)-4-halo-3-hydroxybutyric acid ester.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: December 20, 2016
    Assignee: LONZA LTD.
    Inventors: Ellen Klegraf, Manuela Avi
  • Process for the production of carnitine from ?-lactones
    Patent number: 9394238
    Abstract: The invention relates to a method for the production of L-carnitine, wherein a ?-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into carnitine with trimethylamine (TMA), wherein the ?-lactone is not subjected to a basic hydrolysis step before being contacted with the trimethylamine. The invention also relates to a carnitine having a unique impurity profile.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: July 19, 2016
    Assignee: LONZA LTD.
    Inventors: Paul Hanselmann, Ellen Klegraf
  • Process for the production of 4-chloroacetoacetyl chloride, 4-chloroacetoacetic acid esters, amides and imides
    Patent number: 9227905
    Abstract: The invention relates to process for the continuous production of 4-chloroacetoacetyl chloride, comprising the steps of (a) feeding diketene and chlorine into a thin film reactor and (b) reacting the diketene and chlorine to obtain 4-chloroacetoacetyl chloride. The invention also relates to a process for the production of 4-chloroacetoaceticacid ester, 4-chloroacetoaceticacid amide or 4-chloroacetoaceticacid imide from 4-chloroacetoacetyl chloride obtained according to the inventive process.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: January 5, 2016
    Assignee: LONZA LTD.
    Inventors: Ellen Klegraf, Miguel Angel Caraucan Davila
  • PROCESS FOR THE PRODUCTION OF CARNITINE FROM BETA-LACTONES
    Publication number: 20150126775
    Abstract: The invention relates to a method for the production of L-carnitine, wherein a ?-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into carnitine with trimethylamine (TMA), wherein the ?-lactone is not subjected to a basic hydrolysis step before being contacted with the trimethylamine. The invention also relates to a carnitine having a unique impurity profile.
    Type: Application
    Filed: October 23, 2014
    Publication date: May 7, 2015
    Applicant: LONZA LTD.
    Inventors: Paul Hanselmann, Ellen Klegraf
  • Process for the Production of 4-Chloroacetoacetyl Chloride, 4-Chloroacetoacetic Acid Esters, Amides and Imides
    Publication number: 20140039217
    Abstract: The invention relates to process for the continuous production of 4-chloroacetoacetyl chloride, comprising the steps of (a) feeding diketene and chlorine into a thin film reactor and (b) reacting the diketene and chlorine to obtain 4-chloroacetoacetyl chloride. The invention also relates to a process for the production of 4-chloroacetoaceticacid ester, 4-chloroacetoaceticacid amide or 4-chloroacetoaceticacid imide from 4-chloroacetoacetyl chloride obtained according to the inventive process.
    Type: Application
    Filed: April 25, 2012
    Publication date: February 6, 2014
    Applicant: LONZA LTD
    Inventors: Ellen Klegraf, Miguel Angel Caraucan Davila
  • Process for the production of carnitine by cycloaddition
    Patent number: 8563752
    Abstract: The invention relates to a method for the production of L-carnitine, wherein a chiral ?-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X—CH2—CHO, wherein X is selected from Cl, Br, I and trimethylamine, in the presence of a chiral catalyst.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: October 22, 2013
    Assignee: Lonza Ltd.
    Inventors: Paul Hanselmann, Ellen Klegraf, Stephan Elzner, Wilhelm Quittmann, Daniel Friedrich Fischer
  • PROCESS FOR THE ENZYMATIC PRODUCTION OF CARNITINE FROM BETA-LACTONES
    Publication number: 20130034885
    Abstract: Subject of the invention is a process for the production of L-carnitine, wherein a ?-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into L-carnitine, wherein the process comprises an enzymatic conversion of the ?-lactone into (R)-4-halo-3-hydroxybutyric acid or (R)-4-halo-3-hydroxybutyric acid ester.
    Type: Application
    Filed: July 25, 2012
    Publication date: February 7, 2013
    Inventors: Ellen Klegraf, Manuela Avi
  • Process for removing hydrogen cyanide from ethanedinitrile
    Patent number: 8337796
    Abstract: Process for removing hydrogen cyanide from ethanedinitrile by contacting hydrogen cyanide-containing ethanedinitrile with an organic reagent under formation of a covalent bond.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: December 25, 2012
    Assignee: Lonza AG
    Inventors: Paul Hanselmann, Ellen Klegraf, Wolfgang Wenger
  • Substituted sulfonamide compounds
    Patent number: 8268814
    Abstract: Substituted sulfonamide compounds corresponding to formula I processes for the preparation thereof, pharmaceutical compositions containing such compounds, and the use of such compounds for treating and/or inhibiting pain or other conditions at least partly mediated by the bradykinin 1 receptor.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: September 18, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Melanie Reich, Ellen Klegraf, Stefan Oberboersch, Stefan Schunk, Ruth Jostock, Sabine Hees, Tieno Germann, Michael Engels
  • PROCESS FOR THE PRODUCTION OF CARNITINE BY CYCLOADDITION
    Publication number: 20120022275
    Abstract: The invention relates to a method for the production of L-carnitine, wherein a chiral ?-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X—CH2—CHO, wherein X is selected from Cl, Br, I and trimethylamine, in the presence of a chiral catalyst.
    Type: Application
    Filed: July 20, 2011
    Publication date: January 26, 2012
    Inventors: Paul Hanselmann, Ellen Klegraf, Stephan Elzner, Wilhelm Quittmann, Daniel Friedrich Fischer
  • PROCESS FOR THE PRODUCTION OF CARNITINE FROM BETA-LACTONES
    Publication number: 20120022288
    Abstract: The invention relates to a method for the production of L-carnitine, wherein a ?-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into carnitine with trimethylamine (TMA), wherein the ?-lactone is not subjected to a basic hydrolysis step before being contacted with the trimethylamine. The invention also relates to a carnitine having a unique impurity profile.
    Type: Application
    Filed: July 20, 2011
    Publication date: January 26, 2012
    Inventors: Paul Hanselmann, Ellen Klegraf
  • Process for the preparation of ethanedinitrile
    Patent number: 8088351
    Abstract: The invention relates to a process for the preparation of ethanedinitrile, by reading hydrocyanic acid in the liquid phase with nitric acid in the presence of a cupric ion catalyst.
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: January 3, 2012
    Assignee: Lonza Ltd.
    Inventors: Ellen Klegraf, Thomas Grützner, Jan Keller
  • PROCESS FOR REMOVING HYDROGEN CYANIDE FROM ETHANEDINITRILE
    Publication number: 20110195012
    Abstract: Process for removing hydrogen cyanide from ethanedinitrile by contacting hydrogen cyanide-containing ethanedinitrile with an organic reagent under formation of a covalent bond.
    Type: Application
    Filed: September 15, 2009
    Publication date: August 11, 2011
    Inventors: Paul Hanselmann, Ellen Klegraf, Wolfgang Wenger
  • PROCESS FOR THE PREPARATION OF ETHANEDINITRILE
    Publication number: 20110171102
    Abstract: The invention relates to a process for the preparation of ethanedinitrile, by reading hydrocyanic acid in the liquid phase with nitric acid in the presence of a cupric ion catalyst.
    Type: Application
    Filed: November 10, 2009
    Publication date: July 14, 2011
    Inventors: Ellen Klegraf, Thomas Grützner, Jan Keller
  • SUBSTITUTED SULFONAMIDE COMPOUNDS
    Publication number: 20090275558
    Abstract: Substituted sulfonamide compounds corresponding to formula I processes for the preparation thereof, pharmaceutical compositions containing such compounds, and the use of such compounds for treating and/or inhibiting pain or other conditions at least partly mediated by the bradykinin 1 receptor.
    Type: Application
    Filed: April 9, 2009
    Publication date: November 5, 2009
    Applicant: GRUENENTHAL GmbH
    Inventors: Melanie Reich, Ellen Klegraf, Stefan Oberboersch, Stefan Schunk, Ruth Jostock, Sabine Hees, Tieno Germann, Michael Engels
  • ANTIBACTERIAL 1,4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS
    Publication number: 20080300199
    Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
    Type: Application
    Filed: April 10, 2008
    Publication date: December 4, 2008
    Applicant: Achaogen Inc.
    Inventors: Martin Linsell, Adam Aaron Goldblum, James Aggen, Heinz Ernst Moser, Stephen Hanessian, Kandasamy Pachamuthu, Ellen Klegraf