Patents by Inventor Ellen M. Arruda
Ellen M. Arruda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11944532Abstract: The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free, 3-dimensional engineered tendon constructs.Type: GrantFiled: December 7, 2022Date of Patent: April 2, 2024Assignee: The Regents of the University of MichiganInventors: Lisa M. Larkin, Ellen M. Arruda, Michael Smietana, Asheesh Bedi, Stoyna Novakova
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Patent number: 11898132Abstract: A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.Type: GrantFiled: July 20, 2021Date of Patent: February 13, 2024Assignee: The Regents of the University of MichiganInventors: Lisa M. Larkin, Ellen M. Arruda, Michael J. Smietana, Pablo Moncada-Larrotiz
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Publication number: 20230101406Abstract: The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free, 3-dimensional engineered tendon constructs.Type: ApplicationFiled: December 7, 2022Publication date: March 30, 2023Inventors: Lisa M. Larkin, Ellen M. Arruda, Michael Smietana, Asheesh Bedi, Stoyna Novakova
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Patent number: 11547551Abstract: The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free 3-dimensional engineered tendon constructs.Type: GrantFiled: March 2, 2017Date of Patent: January 10, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Lisa M. Larkin, Ellen M. Arruda, Michael Smietana, Asheesh Bedi, Stoyna Novakova
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Publication number: 20220243156Abstract: A bioreactor capable of producing complex, three-dimensional tissue constructs has improved media transfer and increased controllability with regard to exposure to the external environment. The bioreactor includes an external surface, a first tissue culture side for culturing a first cell source in a first tissue culture support region, a second tissue culture side for culturing a second cell source in a second tissue culture support region, and a plurality of ports. At least one of the ports of the plurality of ports extend from the first tissue culture support region of the first tissue culture side to the external surface. The plurality of ports can include an external port that is configured to be a liquid inlet when the bioreactor is in a first orientation and a gas outlet when the bioreactor is in a second orientation.Type: ApplicationFiled: May 24, 2020Publication date: August 4, 2022Inventors: LISA M. LARKIN, ELLEN M. ARRUDA, MICHAEL J. SMIETANA, PABLO MONCADO-LARROTIZ, HALEY TITINGER
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Publication number: 20210348105Abstract: A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.Type: ApplicationFiled: July 20, 2021Publication date: November 11, 2021Inventors: Lisa M. LARKIN, Ellen M. ARRUDA, Michael J. SMIETANA, Pablo MONCADA-LARROTIZ
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Patent number: 11078454Abstract: A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.Type: GrantFiled: November 21, 2018Date of Patent: August 3, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Lisa M. Larkin, Ellen M. Arruda, Michael J. Smietana, Pablo Moncada-Larrotiz
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Publication number: 20190153375Abstract: A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.Type: ApplicationFiled: November 21, 2018Publication date: May 23, 2019Inventors: Lisa M. LARKIN, Ellen M. ARRUDA, Michael J. SMIETANA, Pablo MONCADA-LARROTIZ
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Publication number: 20190091007Abstract: The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free 3-dimensional engineered tendon constructs.Type: ApplicationFiled: March 2, 2017Publication date: March 28, 2019Inventors: Lisa M. Larkin, Ellen M. Arruda, Michael Smietana, Asheesh Bedi, Stoyna Novakova
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Patent number: 10167444Abstract: A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.Type: GrantFiled: July 15, 2016Date of Patent: January 1, 2019Assignee: The Regents of The University of MichiganInventors: Lisa M. Larkin, Ellen M. Arruda, Michael J. Smietana, Pablo Moncada-Larrotiz
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Patent number: 10160833Abstract: Dissociation of a macroscale version of an aramid fiber leads to the nanofiber form of this polymer. Indefinitely stable dispersions of uniform high-aspect-ratio aramid nanofibers (ANFs) with diameters between 3 and 30 nm controlled by the media composition and up to 10 ?m in length are obtained. ANFs can be processed in transparent thin films using layer-by-layer assembly (LBL) with superior mechanical performance.Type: GrantFiled: April 26, 2013Date of Patent: December 25, 2018Assignee: The Regents of the University of MichiganInventors: Nicholas A. Kotov, Ming Yang, Keqin Cao, Michael D. Thouless, Ellen M. Arruda, Anthony M. Waas, Carlos A. Pons Siepermann, Ryan M. Anderson
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Patent number: 10101129Abstract: A protective device and method of design to protect against multiple blast and impact events for use in any application in which a delicate target has to be protected. The protective device for mitigating the effects of blast or impact employs a first layer having a first acoustic impedance and a second layer having a second acoustic impedance. The second acoustic impedance is different than the first acoustic impedance. The second layer is proximate to the first layer. The first layer and the second layer are chosen collectively to tune the stress waves from the blast or impact events to one or more specific tuned frequencies. A third layer of a visco-elastic material is employed having a critical damping frequency that matches one or more specific tuned frequencies to dissipate the stress waves of the blast and impact event. The third layer is proximate to the second layer.Type: GrantFiled: April 9, 2018Date of Patent: October 16, 2018Assignee: The Regents of The University of MichiganInventors: Michael Thouless, Ellen M. Arruda, Tanaz Rahimzadeh, Anthony M. Waas
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Patent number: 10094641Abstract: A tuning and mitigation system and method for mitigating a blast or impact event having an elastic layer having an acoustic impedance chosen to tune stress waves resulting from the blast or impact to one or more specific tuned frequencies, and a dissipative layer made of a viscoelastic material having a critical damping frequency that matches at least one or more specific tuned frequencies.Type: GrantFiled: April 9, 2018Date of Patent: October 9, 2018Assignee: The Regents of The University of MichiganInventors: Michael Thouless, Ellen M. Arruda, Tanaz Rahimzadeh, Levon Cimonian, Marie Rice
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Publication number: 20180224245Abstract: A protective device and method of design to protect against multiple blast and impact events for use in any application in which a delicate target has to be protected. The protective device for mitigating the effects of blast or impact employs a first layer having a first acoustic impedance and a second layer having a second acoustic impedance. The second acoustic impedance is different than the first acoustic impedance. The second layer is proximate to the first layer. The first layer and the second layer are chosen collectively to tune the stress waves from the blast or impact events to one or more specific tuned frequencies. A third layer of a visco-elastic material is employed having a critical damping frequency that matches one or more specific tuned frequencies to dissipate the stress waves of the blast and impact event. The third layer is proximate to the second layer.Type: ApplicationFiled: April 9, 2018Publication date: August 9, 2018Inventors: Michael THOULESS, Ellen M. ARRUDA, Tanaz RAHIMZADEH, Anthony M. WAAS
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Publication number: 20180224246Abstract: A tuning and mitigation system and method for mitigating a blast or impact event having an elastic layer having an acoustic impedance chosen to tune stress waves resulting from the blast or impact to one or more specific tuned frequencies, and a dissipative layer made of a viscoelastic material having a critical damping frequency that matches at least one or more specific tuned frequencies.Type: ApplicationFiled: April 9, 2018Publication date: August 9, 2018Inventors: Michael THOULESS, Ellen M. ARRUDA, Tanaz RAHIMZADEH, Levon CIMONIAN, Marie RICE
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Patent number: 10041767Abstract: A tuning and mitigation system for mitigating a blast or impact event having a tuning layer assembly having an acoustic impedance chosen to tune stress waves resulting from the blast or impact to one or more specific tuned frequencies, and a dissipative layer assembly made of a viscoelastic material having a critical damping frequency that matches at least one or more specific tuned frequencies.Type: GrantFiled: June 15, 2016Date of Patent: August 7, 2018Assignee: The Regents of The University of MichiganInventors: Michael Thouless, Ellen M. Arruda, Tanaz Rahimzadeh, Levon Cimonian, Marie Rice
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Patent number: 9958238Abstract: A protective device and method of design to protect against multiple blast and impact events for use in any application in which a delicate target has to be protected. The protective device for mitigating the effects of blast or impact employs a first layer having a first acoustic impedance and a second layer having a second acoustic impedance. The second acoustic impedance is different than the first acoustic impedance. The second layer is proximate to the first layer. The first layer and the second layer are chosen collectively to tune the stress waves from the blast or impact events to one or more specific tuned frequencies. A third layer of a visco-elastic material is employed having a critical damping frequency that matches one or more specific tuned frequencies to dissipate the stress waves of the blast and impact event. The third layer is proximate to the second layer.Type: GrantFiled: November 14, 2014Date of Patent: May 1, 2018Assignee: The Regents of The University of MichiganInventors: Michael Thouless, Ellen M. Arruda, Tanaz Rahimzadeh, Anthony M. Waas
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Patent number: 9592255Abstract: The invention relates to scaffold-free three dimensional nerve fibroblast constructs and method of generating the nerve fibroblast constructs. The invention also relates to methods or repairing nerve transection and replacing damaged nerve tissue using the nerve fibroblast constructs of the invention.Type: GrantFiled: July 1, 2011Date of Patent: March 14, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Lisa M. Larkin, Ellen M. Arruda, Jennifer Baltich, Aaron Adams, Leah Hatch-Vallier
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Publication number: 20170037354Abstract: A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.Type: ApplicationFiled: July 15, 2016Publication date: February 9, 2017Inventors: Lisa M. LARKIN, Ellen M. ARRUDA, Michael J. SMIETANA, Pablo MONCADA-LARROTIZ
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Publication number: 20170016700Abstract: A tuning and mitigation system for mitigating a blast or impact event having a tuning layer assembly having an acoustic impedance chosen to tune stress waves resulting from the blast or impact to one or more specific tuned frequencies, and a dissipative layer assembly made of a viscoelastic material having a critical damping frequency that matches at least one or more specific tuned frequencies.Type: ApplicationFiled: June 15, 2016Publication date: January 19, 2017Inventors: Michael THOULESS, Ellen M. ARRUDA, Tanaz RAHIMZADEH, Levon CIMONIAN, Marie RICE