Patents by Inventor Ellen M. Berman

Ellen M. Berman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted quinazolinones as anticancer agents
    Patent number: 4857530
    Abstract: Novel 6-substituted-4(3H)-quinazolinones are described as well as methods for the preparation and pharmaceutical composition of same, which inhabit the enzyme thymidylate synthase (TS) and are thus useful as anticancer agents.
    Type: Grant
    Filed: November 3, 1987
    Date of Patent: August 15, 1989
    Assignee: Warner-Lambert Company
    Inventors: Ellen M. Berman, Leslie M. Werbel, Dennis J. McNamara
  • Substituted benzonitriles
    Patent number: 4677219
    Abstract: An improved process for the preparation of 6-substituted-5-alkyl-2,4-quinazolinediamines, useful in the production of trimetrexate and similar antifolate agents, together with several novel intermediates are disclosed.
    Type: Grant
    Filed: July 17, 1986
    Date of Patent: June 30, 1987
    Assignee: Warner-Lambert Company
    Inventors: Ellen M. Berman, Mark J. Suto
  • Antibacterial benzo(chalcogeno)[4,3,2-cd]indazoles
    Patent number: 4604390
    Abstract: Substituted 2H-[1]benzopyrano[4,3,2-cd]indazoles, 2H-[1]benzothiopyrano[4,3,2-cd]indazoles, and 2H-[1]benzoselenino[4,3,2-cd]indazoles have demonstrated pharmacological activity against a broad spectrum of Gram-positive and Gram-negative bacteria, yeasts, and fungi, as well as activity against the L1210 and P388 murine leukemia cells lines.Pharmaceutical compositions containing the compounds and methods of employing the compounds in methods of treating bacterial or fungal infections and of inhibiting the growth of neoplasms in mammals are also disclosed.
    Type: Grant
    Filed: May 24, 1985
    Date of Patent: August 5, 1986
    Assignee: Warner-Lambert Company
    Inventors: Edward F. Elslager, Leslie M. Werbel, Daniel F. Ortwine, Donald F. Worth, Howard D. H. Showalter, David B. Capps, Ellen M. Berman, Vlad E. Gregor, Anthony D. Sercel