Abstract: Nanostructured model device of energy sensing and monitoring apparatus comprises arrays of orderly nanotubes parallel oriented forming 3D cross-bar with vertically oriented nanopillars membrane through self-assembly affixed onto an electrode; the membrane comprises active sites of an innate Heat Shock Protein (HSP) cross-linked with conductive polymers on an electrode to be able to monitor toxic protein ?-amyloid (A?) energy landscape change, and the reversed membrane potential was restored in the presence of an antibiotic drug. By depositing the HSP60 polymer mixtures on a top of a MMP-2 membrane, it promoted a moonlighting protein network that was able to 97.3% impaired A? refolding with imprecision 0.05%, which was not depending on antibiotic drug's concentration, wherein to be able to maintain the RMP.

Abstract: Topological superconductive and memristive nanostructured toroidal-tower array devices are invented for direct electrochemical sensing of multiple biomarkers based on the biomimetic glucose . . . pyruvate . . . acetyl CoA (ACoA) fuel energy pathway of mitochondria. The device comprises flexible fractional Josephson junctions (FFJJ) made of innate organometallic protein cross-linked with conductive polymers forming a first layer membrane on the electrode surface, a medium comprising of glucose and acetyl CoA (ACoA) molecules (as the GA medium), serves as an insulator or a conductor when pyruvate molecules activated the medium, and the second layer comprising of an innate Heat Shock Protein (HSP) cross-linked with the similar polymers on top of the first layer.

Abstract: An electromagnetic MEM-transformer includes arrays of nanometer sized first toroidal made by self-assembling organic polymer conductive membrane on top of the first electrode, a vertical solenoid was inserted in the cavity of the first toroid, made by second nano “donuts” cyclodextrin toroids, in the hollow cavity comprising of different electronegativity functional groups; an organic laminate agent forms a linen lining the first cavity of the arrayed toroids in cross bars that is perpendicular to the first and second toroid and leave nanometer space air gap between them, upon applied a DC voltage or a current cross the first electrode with membrane and the second electrode without a membrane, changing currents flow in the bipolar toroids in electron-relay circular forms provide electromagnetism flux and air gaps exists as dielectric substance providing meminductance to the toroids and the changing memcapacitance is also in a hysteresis wave form with on-off switches.

Abstract: The present invention provides a handheld electrochemical cancer monitoring and therapeutic device comprising a key component of a sensor compartment comprising an electrode with a substrate having a nanostructured biomimetic membrane attached thereto and an open window allows the electrode fixed in a socket of the sensor compartment to the window to be contacted to the human breast; in the base of the device there is a window for cancer heat release result displayed in a contour map format when the device applied a fixed current to induce cancer cell's bio-communication with the sensor membrane selectively under noninvasive, antibody-free and reagent-free conditions. Methods for therapeutic function and monitoring of early asymptomatic normal human breast in vivo and therapeutic treatment of breast cancer cell line in vitro are disclosed.

Abstract: The present invention provides a single cancer direct detection device comprises an electrode having a nanopore biomimetic membrane inducing a bio-communication signal by cancer cells selectively under antibody-free and label-free condition. Methods of detecting cancer cells and monitoring cancer progresses in a contour map format are also discussed. In particular, the cancer cell heat release map comprises multiple variables correlations, a ratio of “Action potential/Resting potential” (RAPRP) as a special biomarker for the variable along with other variables of current or concentration makes visual display cancer progresses possible compared with normal cells which have negligible heat release.

Abstract: Nanobiomimetic supercapacitors comprise an “Electron Well” and an “Electron-Dam” Membrane Electrode Assembling (MEA); the “Electron-Well” MEA compromises an electrode comprising a substrate of glassy carbon; a self-assembling membrane comprises a polymer matrix; wherein the polymer matrix is comprised of an electrically conductive copolymer; wherein the copolymer is further comprised of one or more first ?-cyclodextrin molecules having at least one or more free acetyl groups; one or more polyethylene glycol molecules; one or more poly(4-vinylpyridine) molecules; and one or more second ?-cyclodextrin molecules; the self-assembling membrane having a surface structure comprising one or more nanopores and pillars; the nanopores and pillars are vertically oriented on the substrate to form nanopore and pillar array; the “Electron-Dam” MEA compromises the nanopore/pillar layer sealed with an embedded hydrophobic aromatic substance having a flat lid structure; Wherein the MEA can be as either said positive or negativ

Abstract: The present invention provides a novel electrochemical device and a cancer cell heat release map method to visually display the cancer progresses. The novel device comprises an electrode having a nanopore biomimetic electron-relay network with imidazolium-ATP of cancer cell-water-pyridine at the active sites that mimic the electron-relaying between His 516 and N(5)-FAD of GOx for the purpose to selectively detect triple-negative breast cancer cell at single cell concentration and it rejects brain cancer cell. The device is fast in millisecond to detect cancers without sample preparation and without interference from other substances, such glucose and proteins under reagent-free conditions. A unique biomarker of the ratio of “Action/Resting” cell membrane potential can be used to monitor the cancer progress against the normal cells. A visual contour map of a multiple variable correlation method provided to assess the heat release from the cancer cells against the normal cells is presented.

Abstract: Nanobiomimetic supercapacitors comprise an “Electron Well” and an “Electron-Dam” Membrane Electrode Assembling (MEA); the “Electron-Well” MEA compromises an electrode comprising a substrate of glassy carbon; a self-assembling membrane comprises a polymer matrix; wherein the polymer matrix is comprised of an electrically conductive copolymer; wherein the copolymer is further comprised of one or more first ?-cyclodextrin molecules having at least one or more free acetyl groups; one or more polyethylene glycol molecules; one or more poly(4-vinylpyridine) molecules; and one or more second ?-cyclodextrin molecules; the self-assembling membrane having a surface structure comprising one or more nanopores and pillars; the nanopores and pillars are vertically oriented on the substrate to form nanopore and pillar array; the “Electron-Dam” MEA compromises the nanopore/pillar layer sealed with an embedded hydrophobic aromatic substance having a flat lid structure; Wherein the MEA can be as either said positive or negativ

Abstract: The present invention provides a novel biosensor and measuring method. The novel biosensor of the present invention comprises an electrode having a nanopore structured and catalytically active cyclodextrin attached thereto. The biosensor of the present invention has demonstrated robust analytical performance for direct glucose measurement without mediators or without using native enzyme, which is especially beneficial in the hypoglycemia range.

Abstract: The present invention provides a novel biosensor and measuring method. The novel biosensor of the present invention comprises an electrode having a nanopore structured and catalytically active cyclodextrin attached thereto. The biosensor of the present invention has demonstrated robust analytical performance for direct glucose measurement without mediators or without using native enzyme, which is especially beneficial in the hypoglycemia range.

Abstract: The present invention provides a novel biosensor for the detection of chemicals of interest. The novel biosensor of the present invention comprises an electrode having a catalytically active cyclodextrin attached thereto. The present invention will be useful for the detection of materials in a wide variety of samples. In particular, the present invention will permit the detection of nitrophenyl esters.