Patents by Inventor Ellen T. Roche
Ellen T. Roche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230248566Abstract: An oral appliance and method for treating a sleep disorder in a subject are disclosed. The appliance includes, among other elements, a palatal overlay element that engages a portion of the dorsal surface of the subject's tongue, stabilizing the tongue in a superior direction toward the hard palate. The method generally involves stabilizing the dorsal surface of a subject's tongue in a superior direction toward the subject's hard palate.Type: ApplicationFiled: June 17, 2021Publication date: August 10, 2023Inventors: RAVI RASALINGAM, TARSHA WARD, JOSE VENEGAS, Ellen T. Roche
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Patent number: 11627949Abstract: An insertable catheter device includes a shaft including a proximal end and a distal end, an expandable balloon, and an actuator configured to expand and retract the expandable balloon. The actuator includes a fluid conduit that extends through the shaft and is coupled with the expandable balloon to enable inflation and retraction of the expandable balloon via injection or withdrawal of a fluid to or from the expandable balloon via the fluid conduit. The expandable balloon is displaceably retractable into the shaft and extendable from the shaft. A fluid pump is coupled with the fluid conduit to pump the fluid through the fluid conduit. A patch is positioned to be displaced by the expandable balloon when the expandable balloon is inflated, and the expandable balloon is displaceably retractable into the shaft and displaceably extendable from the shaft.Type: GrantFiled: February 4, 2020Date of Patent: April 18, 2023Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey Michael Karp, Yuhan Lee, Pedro J. del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman
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Patent number: 11197944Abstract: The present invention provides methods and compositions for promoting regeneration of a tissue, methods for preventing or reducing inflammation of a tissue, methods for preventing or reducing fibrosis of a tissue, methods for increasing a mass of a tissue, methods for increasing a level of oxygen available to a tissue, methods for increasing a rate of metabolic waste removal from a tissue, methods for increasing blood perfusion to a tissue, and methods of treating severe muscle tissue damage in a subject in need thereof by contacting the tissue with a composition that is suitable for applying cyclic mechanical compression to the tissue.Type: GrantFiled: November 18, 2016Date of Patent: December 14, 2021Assignees: President and Fellows of Harvard College, CHARITÉ UNIVERSITÄTSMEDIZIN BERLINInventors: Christine A. Cezar, Conor J. Walsh, David J. Mooney, Ellen T. Roche, Herman H. Vandenburgh, Georg N. Duda
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Publication number: 20210350725Abstract: A biorobotic hybrid heart that preserves organic intracardiac structures and mimics cardiac motion by image-guided replication of the cardiac myofiber architecture of the left ventricle with an active synthetic myocardium that drives the motion of the heart. The active soft tissue mimic is adhered to the organic endocardial tissue in a helical fashion using a custom-designed adhesive to form a flexible, conformable, and watertight organosynthetic interface.Type: ApplicationFiled: March 5, 2021Publication date: November 11, 2021Inventors: Clara Park, Xuanhe Zhao, Hyunwoo Yuk, Christopher Tam Nguyen, Ellen T. Roche
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Publication number: 20200222582Abstract: The present invention provides methods and compositions for promoting regeneration of a tissue, methods for preventing or reducing inflammation of a tissue, methods for preventing or reducing fibrosis of a tissue, methods for increasing a mass of a tissue, methods for increasing a level of oxygen available to a tissue, methods for increasing a rate of metabolic waste removal from a tissue, methods for increasing blood perfusion to a tissue, and methods of treating severe muscle tissue damage in a subject in need thereof by contacting the tissue with a composition that is suitable for applying cyclic mechanical compression to the tissue.Type: ApplicationFiled: November 18, 2016Publication date: July 16, 2020Inventors: Christine A. Cezar, Conor J. Walsh, David J. Mooney, Ellen T. Roche, Herman H. Vandenburgh, Georg N. Duda
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Publication number: 20200179050Abstract: An insertable catheter device includes a shaft including a proximal end and a distal end, an expandable balloon, and an actuator configured to expand and retract the expandable balloon. The actuator includes a fluid conduit that extends through the shaft and is coupled with the expandable balloon to enable inflation and retraction of the expandable balloon via injection or withdrawal of a fluid to or from the expandable balloon via the fluid conduit. The expandable balloon is displaceably retractable into the shaft and extendable from the shaft. A fluid pump is coupled with the fluid conduit to pump the fluid through the fluid conduit. A patch is positioned to be displaced by the expandable balloon when the expandable balloon is inflated, and the expandable balloon is displaceably retractable into the shaft and displaceably extendable from the shaft.Type: ApplicationFiled: February 4, 2020Publication date: June 11, 2020Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey Michael Karp, Yuhan Lee, Pedro J. del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman
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Patent number: 10588695Abstract: An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect (e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.Type: GrantFiled: May 13, 2015Date of Patent: March 17, 2020Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey Michael Karp, Yuhan Lee, Pedro J. del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman
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Patent number: 10058647Abstract: A biomimetic actuation device includes a flexible substrate, conformable for disposition about an object, defining an apex and a base, bearing at least one soft actuator configured to change state from a first state to a second state upon introduction of a pressurized fluid to an internal volume of the at least one soft actuator.Type: GrantFiled: October 6, 2014Date of Patent: August 28, 2018Assignees: President and Fellows of Harvard College, The Children's Medical Center CorporationInventors: Ellen T. Roche, Steven Obiajulu, Conor J. Walsh, David J. Mooney, Frank A. Pigula
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Publication number: 20180104059Abstract: Therapy is provided to living tissue by contacting the living tissue with at least one reservoir loaded with cells or a therapeutic composition, wherein the reservoir is in fluid communication with at least one conduit that includes a refilling port. A constituent selected from (a) cells, (b) bioagents from the cells or (c) the therapeutic composition is released from the reservoir to the living tissue. The reservoir is then refilled with (i) cells, (ii) nutrients for cells, or (iii) additional therapeutic composition; and (a) cells, (b) bioagents from the cells or (c) the therapeutic composition continue to be released from the reservoir to the living tissue after the refilling.Type: ApplicationFiled: March 11, 2016Publication date: April 19, 2018Applicants: President and Fellows of Harvard College, Royal College of Surgeons in IrelandInventors: Ellen T. Roche, Kevin C. Galloway, William Whyte, Conor J. Walsh, Hugh O'Neill, David J. Mooney, Garry P. Duffy
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Publication number: 20170079717Abstract: An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect (e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.Type: ApplicationFiled: May 13, 2015Publication date: March 23, 2017Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey Michael Karp, Yuhan Lee, Pedro J. del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman
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Publication number: 20160346449Abstract: A biomimetic actuation device includes a flexible substrate, conformable for disposition about an object, defining an apex and a base, bearing at least one soft actuator configured to change state from a first state to a second state upon introduction of a pressurized fluid to an internal volume of the at least one soft actuator.Type: ApplicationFiled: October 6, 2014Publication date: December 1, 2016Inventors: Ellen T. Roche, Steven Obiajulu, Conor J. Walsh, David J. Mooney, Frank A. Pigula