Abstract: A prepolymer comprising an acid group is made by a process comprising the step of contacting: (i) a di-isocyanate, (ii) a polyol containing an acid group, and (iii) a polyol without an acid group, the contacting conducted under reaction conditions and in a solvent consisting essentially of: (A) a first component consisting essentially of at least one glycol ether ketone, and (B) optionally, a second component consisting of at least one aprotic glycol ether. The prepolymer is useful in the preparation of water-based polyurethane dispersions.

Abstract: The Chair Exerciser is an apparatus and method to exercise one's core, back, and legs while working on tasks that are normally performed seated. These tasks include computer work, watching television, or computer gaming. The Chair Exerciser fits on a regular chair and one sits upon it. The Chair Exerciser's resistance can be adjusted to the suit the needs of the user. The multitasking of work and exercise is an attractive benefit to the Chair Exerciser. The Chair Exerciser can also be formed as an integral part of the chair as opposed to a portable unit.

Abstract: A system is disclosed. The system has a remediation module, comprising computer-executable code stored in non-volatile memory, a processor, a buyer device of a buyer, and a seller device of a seller. The remediation module, the processor, the buyer device, and the seller device are configured to receive asset data of the seller, receive exception rules of the buyer, determine exceptions of the asset data based on the exception rules, display the exceptions via at least one of the buyer device or the seller device, and update the asset data based on the displayed exceptions.

Abstract: Viscoelastic hydrogel microparticles are used for repair of tissue defects and injuries or filling and occlusion of anatomical structures. These are administered as a microparticle suspension using a catheter, syringe, steerable catheter tip, or comparable technology into the site, where they can be further stabilized by crosslinking or sealing, or through incorporation of a support or encapsulating structure. Materials and methods for solidifying, stabilizing and sealing these materials can be used that are also biocompatible and easily deployed with catheters in the body. The micron sized interstitial spacing provides a scaffold for ingrowth and migration of cells into the gel matrices.

Abstract: The invention generally relates to dosage regimes of anti-Cluster of Differentiation 73 (CD73) antibodies and/or anti-ectoenzyme ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) antibodies, used in methods of treatment of cancer in a subject, as well as dosage regimes of anti-CD73 antibodies for use in treating cancer. The invention further generally relates to dosage regimes of combinations of agents, such as combinations comprising anti-CD73 antibodies and/or anti-ENTPD2 antibodies and at least one or more of a PD-1 inhibitor, and an adenosine A2AR antagonist.

Abstract: An absorbent article can have a topsheet layer, a liquid impermeable layer, and an absorbent core positioned between the topsheet layer and the liquid impermeable layer. The absorbent article can further include an exudate management layer in fluid communication with the topsheet layer. In various embodiments, the exudate management layer can be positioned on a body facing surface of the topsheet layer. In various embodiments, the exudate management layer can be positioned between the topsheet layer and the absorbent core. The exudate management layer has a first component which defines an opening for direct passage of body exudates into the absorbent core. The exudate management layer has a second component which at least partially overlaps the first component of the exudate management layer and further extends in the longitudinal direction of the absorbent article in a direction towards the posterior region of the absorbent article.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TfR1. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, and multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder through TfR1 mediated delivery of a therapeutic agent.

Abstract: The invention relates to an immunomodulatory substance(s) and/or a skin-conditioning agent for use in a method for treating and/or preventing an inflammatory disease, immunological disease and/or autoimmunological disease in a subject, wherein the method comprises a step (A) selected from one or more of: generating an accumulation of PBMCs within the skin, generating a vasodilation of the capillaries within the skin, generating an increased blood volume within the skin, generating an increased sO2 within the skin, generating an increased rHb within the skin, generating an increased temperature on the skin, generating a redness on the skin, administering conditioning energy to the skin, administering a skin-conditioning agent to the skin or administering PBMCs to the skin of the subject; and the method further comprises step (B) administering a first immunomodulatory substance(s) to the skin of the subject and/or step (C) administering a second immunomodulatory substance(s) to the skin of the subject.

Abstract: A method and system for automated and semi-automated predictable, consistent, safe, effective, and lumen-specific and patient-specific cryospray treatment of airway tissue in which treatment duration is automatically set by the system following entry of patient information and treatment location information into the system by the user, and treatment spray is automatically stopped by the system when the automatically selected treatment duration has been achieved as determined by the system.

Abstract: A method and system for automated and semi-automated predictable, consistent, safe, effective, and lumen-specific and patient-specific cryospray treatment of airway tissue in which treatment duration is automatically set by the system following entry of patient information and treatment location information into the system by the user, and treatment spray is automatically stopped by the system when the automatically selected treatment duration has been achieved as determined by the system.

Abstract: The present disclosure concerns methods of detecting viral respiratory infections by analyzing biomarkers in a viral transport medium sample. In various embodiments the biomarkers are assessed by measuring mRNA or protein. In certain embodiments the biomarkers are nasal-virus induced molecules.

Abstract: Storage array health scores based on alerts are auto-corrected by using alert validation and alert matching to identify missed, stale, and redundant alerts. In response to restoration of an event daemon or reboot of a storage management server, each alert associated with each storage array is validated to determine whether current state of storage array hardware or a logical object differs from the state indicated in the alert. Alerts that differ from current state are updated or invalidated and the health score is recalculated. Responsive to receipt of a new alert, existing alerts associated with the same storage array hardware or logical object are identified and Jaro-Winkler distance between the identified alerts and the new alert is calculated. Any existing alert for which the Jaro-Winkler distance relative to the new alert is greater than or equal to 0.9 is deleted and the health score is recalculated.

Abstract: A financial close automation (FCA) system receives or retrieves account data from one or more enterprise resource planning products (ERPs). The FCA examines the balance sheet for a given account and determines whether the account is auto-certifiable, and whether the unknown balance is below a threshold amount. If the answer to either inquiry is no, the FCA generates a task for the general ledger owner to provide an explanation for the discrepancy. A task is the created for a manager to review the provided explanation. If the manager does not approve of the provided explanation, additional information may be required. Once the manager approves the provided explanation for the discrepancy, the account is certified. If the account is auto-certifiable and the unknown balance is below the threshold amount, the account is auto-certified.

Abstract: A method of forming an etched part includes forming a substrate including a thermoset resin and etching a surface of the substrate. The thermoset resin includes a vat photopolymerization (VPP) thermoset resin and at least one of an etchable phase and etchable particles disposed within the VPP thermoset resin. The etching removes the etchable phase from the VPP thermoset resin at the surface of the substrate such that a plurality of micro-mechanical bonding sites are formed on an etched surface of the substrate.

Abstract: Techniques for clustering a plurality of virtual space servers based on communication platform data are discussed herein. In some examples, a user may post a message to a virtual space of a communication platform. The communication platform may transmit the message to virtual space servers configured to manage the virtual space within which the message originated. In such examples, the communication platform may identify clusters of virtual space servers and determine within which cluster the corresponding virtual space server is located. Virtual space servers may be clustered based on attribute data associated with communication platform data. In some examples, the communication platform may send the message to the virtual space server which may send the message to subscribing gateway servers. Further, the gateways servers may send the message to the recipient client devices. The recipient client devices may display the message via a user interface of the communication platform.

Abstract: A method for controlling a printer includes receiving a set of first variables for the printer, determining, using a machine-learning program, one or more second variables based on the set of first variables, and controlling a printer to perform a print job based on the set of first variables and the one or more second variables. The first and second variables may correspond to different types of printer settings. The machine-learning program may determine the second variables using a classifier model that may prevent partial curing or drying, print media deformation and/or other defects.

Abstract: An electronic device includes a device housing and a blade assembly carrying a blade and slidably coupled to the device housing. The electronic device includes a translation mechanism operable to slide the blade assembly relative to the device housing. The electronic device includes one or more processors operable with the translation mechanism. The one or more processors can automatically cause the blade assembly to translate in response to one or more triggers, some of which may be learned by an artificial intelligence classifier.

Abstract: A connector assembly includes a plurality of receptacle modules configured to be received in corresponding module channels in a receptacle cage. Each receptacle module has a housing holding a contact assembly. The housing has a card slot at a front of the housing. The contact assembly has contacts terminated to ends of cables. The contacts have mating ends at the card slot to mate with a pluggable module received in the receptacle cage. The connector assembly includes an integrator having integrator walls forming a plurality of chambers. Each chamber receives the corresponding receptacle module. The connector assembly includes a latch coupled to the integrator. The latch configured to be latchably coupled to the receptacle cage.

Abstract: The disclosed technology teaches a method for interactively generating a graphical summary of a meeting that provides a reflection of a group's conversation with textual and graphical elements in a tapestry. The method comprises a combination of transcript analysis using natural language processing or other machine learning models and automatic selection of graphic symbols detected as relevant to the transcript by statistical analyses. The method further includes the ability to interact with a generated tapestry for additional customization, wherein a user's customization selection is fed back into the machine learning models to fine tune the result.

Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.