Abstract: Disclosed are methods, systems, devices, apparatus, media, design structures, and other implementations, including a method that includes receiving a source document, applying one or more pre-processes to the source document to produce contextual information representative of the structure and content of the source document, and transforming the source document, based on the contextual information, to generate a question-and-answer searchable document.

Abstract: The invention relates to 1,5-benzothiazepine and 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.

Abstract: A cut warning system can include a valve sleeve defining a cavity, the valve sleeve defining a bottom sealing surface within the cavity; a pipeline extending through the cavity; a drilling machine including a shell cutter, the shell cutter defining a bottom edge, the drilling machine configured to axially advance the shell cutter from a pre-engagement position towards the bottom sealing surface, the pipeline positioned between the shell cutter and the bottom sealing surface in the pre-engagement position; and a signaling element positioned within the cavity, the signaling element configured to produce a signal when the shell cutter reaches a post-engagement position, the bottom edge being axially positioned between the pipeline and the bottom sealing surface.

Abstract: A system and method for displaying dynamic time-based ranging over a moving map determines position, heading, and airspeed information of an ownship. Based on the positioning information of the ownship, the moving map projects the ownship forward in time and superimposes on the moving map (which may already include distance-based ranging information) time-based ranging information indicating a projected range of positions of the ownship at future or subsequent times relative to the current time. The displayed time-based ranging indicators may be arcuate in shape but adjusted to account for dynamic factors such as headwinds or tailwinds that may affect the time required for the ownship to reach a target at a given distance.

Abstract: A system to automatically detect at least one physiological state is disclosed. The system includes a single probe for insertion within a subject that has an analyte sensor array for continuous monitoring of at least glucose and a second analyte. The system further includes an electronics module that includes a power supply, a processor, memory and a bi-directional communications module. When the electronics module is coupled with the analyte sensor array the power supply delivers power to the analyte sensor array and the processor. The processor analyzing glucose and the second analyte data to detect a first physiological state from a plurality of physiological states.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2.

Abstract: An ultrasonic surgical instrument and method of assembly with a predetermined alignment includes first and second modular assemblies and an electrical lockout. The first modular assembly includes at least a portion of an end effector configured to manipulate a tissue. The second modular assembly includes a transducer power circuit and an activation switch electrically connected to the transducer power circuit. The electrical lockout is electrically connected to the transducer power circuit and configured to inhibit the activation switch from powering the ultrasonic transducer with the first and second modular assemblies misaligned from the predetermined alignment such that the first and second modular assemblies are in a locked-out state. The electrical lockout is further configured to allow the activation switch to power the ultrasonic transducer with the first and second modular assemblies in the predetermined alignment such that the first and second modular assemblies are in an operational state.

Abstract: Methods, apparatuses, and computing systems are provided for integrating logic services with a group communication service. In an implementation, a method may include receiving a spoken message from a communication node in a communication group and determining that the spoken message relates to a logic service and transferring the spoken message to a voice assistant service with an indication that the spoken message relates to the logic service. The method also includes receiving status information from the logic service indicative of a status of a networked device associated with the logic service. The further method includes sending an audible announcement to the communication nodes in the commutation group expressive of the status of the networked device.

Abstract: Green bean plants exhibiting resistance to Sclerotinia sclerotiorum are provided, together with kits and methods for controlling Sclerotinia sclerotiorum infection. Such methods include the application of fungicidal Bacillus subtilis strains to plants exhibiting resistance to Sclerotinia sclerotiorum.

Abstract: Radiopharmaceutical compounds of general Formula (I) are based on a sarcophagine cage having a PEG linker-group X through to a group Y capable of binding to a biological receptor and an albumin-binding group Z for the treatment, diagnosis or imaging of diseases including cancer, and the production of such compounds and their complexes.

Abstract: A computer system for testing a user interface includes a memory circuit and a processor circuit configured to execute instructions including obtaining a state of the user interface. The instructions include setting a current position to a specified location within the user interface. The instructions include executing user interface tests to generate multiple paths. The instructions include determining a shortest path toward a goal location by identifying a path having a minimum distance that satisfies criteria. A distance for the path is based on two-dimensional distances between pairs of consecutive positions that include the current position as well as positions, along the particular path, of user interface elements requiring interaction to satisfy the criteria.

Abstract: A durable absorbent pant is disclosed. The pant includes an outer pant structure and a gusset assembly disposed at least partially in a crotch portion. The gusset assembly includes an absorbent layer, a barrier layer beneath the absorbent layer, and an edge barrier overlying portions of a wearer-facing surface of the gusset assembly along a perimeter edge of the gusset assembly, and effectively continuing over and around the perimeter edge to an outward-facing surface of the gusset assembly. The edge barrier may be formed of a liquid impermeable edge sealing strip material joined to the barrier layer, or, the edge barrier may be formed of an extension of the barrier layer. The gusset assembly may be affixed within the crotch portion by various disclosed mechanisms.

Abstract: A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.

Abstract: A composite pressure vessel assembly includes a plurality of lobes, each of the lobes having at least one interior wall and at least one curved wall, the plurality of lobes being positioned in a side by side arrangement and extending in a longitudinal direction from a first end to a second end. Also included is a plurality of end caps disposed at the ends of the lobes, wherein the plurality of lobes and end caps are formed of at least one fiber-reinforced polymer. A method of manufacturing a composite pressure vessel assembly is provided. The method includes forming a plurality of lobes consisting of at least one fiber-reinforced polymer. The method also includes forming a main body with the plurality of lobes, the lobes disposed in a side by side arrangement.

Abstract: Disclosed is a process for producing a propylene polymer composition comprising a long chain branched propylene polymer, wherein the propylene polymer composition has a) a melt flow rate MFR2 (230° C., 2.16 kg) of 0.8 to 6.0 g/10 min b) a xylene hot insolubles (XHU) fraction in an amount of not more than 0.80 wt %, based on the total weight amount of the propylene polymer composition, c) a melting temperature Tm of at least 160.0° C., d) a F30 melt strength of from 5.0 to less than 30.0 cN, and e) a heat distortion temperature (HDT) of at least 108° C., the process comprising reactive modification of a propylene polymer in the presence of a peroxide. Also disclosed is an article comprising said propylene polymer composition.

Abstract: A printer includes: a body defining a media enclosure configured to receive a media supply; an indicator assembly supported by an outer wall of the body, the indicator assembly including a plurality of substantially contiguous illumination surfaces illuminated by respective ones of a set of lights supported within the body; a controller supported by the body, the controller configured to: (i) obtain an operational status of the printer, (ii) retrieve, from a mapping repository, a set of notification control parameters corresponding to the operational status, and (iii) control the set of lights according to the notification control parameters.

Abstract: Provided herein are immunomodulatory proteins and compositions (e.g., pharmaceutical compositions) comprising the same; as well as methods of making the immunomodulatory proteins and compositions. The immunomodulatory proteins provided herein are useful in pharmaceutical compositions and methods of treating IL-10 responsive diseases.

Abstract: A solid compounded fertilizer in the form of discrete particles, the solid fertiliser having a biological release profile, the solid fertilizer comprising, in a single particle a torrefied organic waste comprising labile carbon and a binder. The torrefied organic material is bound by the binder into the single particle thereby the labile carbon of the organic material is readily available for metabolism by microbes following application of the compounded fertilizer composition to soil or growing media.

Abstract: An ultrasonic surgical instrument includes a first modular assembly including at least one operator input feature an ultrasonic transducer supported by the first modular assembly, and a second modular assembly configured to be removably coupled with the first modular assembly. The second modular assembly includes at least a portion of an end effector extending distally from a distal end portion of the second modular assembly. The instrument includes a mechanical lockout assembly configured to switch between at least an unlocked configuration and a locked configuration. In the locked configuration, the first modular assembly and the second modular assembly are partially coupled together such that the operator is physically prevented from activating the instrument using the operator input feature. In the unlocked configuration, the first modular assembly and the second modular assembly are completely coupled together and the operator is able to activate the instrument using the operator input feature.

Abstract: The present disclosure provides novel nucleic acid-guided nucleases and methods of using the nucleases for genome editing. The present disclosure further provides a system for editing a target region in a genome comprising a nucleic acid-guided nuclease, a heterologous guide nucleic acid for complexing with the nucleic acid-guided nuclease, and an editing polynucleotide configured to bind to the target region.