Abstract: The present invention provides a standard testing methodology for making quantitative determinations as to the chemical resistance of thermoplastics commonly used for non-disposable medical devices by evaluating the retention of tensile and/or impact properties of the thermoplastic materials after exposure to chemicals associated with healthcare grade disinfectants. Versions of the test methods may be used with any of a variety of different thermoplastic materials, each having a different stiffness or elastic modulus; and versions of the test methods may be used with any of a variety of different hospital grade cleaning agents or disinfectants. Using the methodology of embodiments of the present invention, different thermoplastic materials may be tested against different cleaners or disinfectants to provide a uniform basis for comparison.