Patents by Inventor Ellen Vitetta

Ellen Vitetta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for modifying toxic effects of proteinaceous compounds
    Publication number: 20060100135
    Abstract: The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS.
    Type: Application
    Filed: October 31, 2005
    Publication date: May 11, 2006
    Inventors: Ellen Vitetta, Victor Ghetie, Joan Smallshaw, Roxana Baluna
  • Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
    Publication number: 20060099213
    Abstract: This invention discloses monoclonal antibodies (MAbs) which have little or no signaling activity as monomers become potent anti-tumor agents when they are converted into homoconjugates. The homoconjugates exert anti-growth activity by signaling G0/G1 arrest or apoptosis, depending upon which cell surface molecule they bind. This activity is specific and does not require an Fc portion. These conjugates are potent, anti-tumor agents.
    Type: Application
    Filed: April 8, 2002
    Publication date: May 11, 2006
    Applicant: Board of Regents, The University of Texas System
    Inventors: Maria-Ana Ghetie, Jonathan Uhr, Ellen Vitetta