Patents by Inventor Elles Steensma

Elles Steensma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of urea variants as affinity ligands
    Patent number: 7645903
    Abstract: The present invention relates to an IgG-binding compound, which more specifically has affinity for human IgGs of ?-type and functional derivatives thereof. More specifically, the compound according to the invention comprises an N,N-alkylated urea moiety located between an aromatic part and another part, which is a linear or cyclic substituted or unsubstituted aliphatic group. The compound binds to a pocket-shaped binding site present on all human IgG ?-Fabs, which site is located between the two domains (CH1 and CL) of its constant part. Accordingly, the compound according to the invention is a ligand for human IgGs of ?-type, and consequently, the invention also relates to a separation matrix for affinity chromatography, which matrix comprises said compound, as well as to other uses of the compound.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: January 12, 2010
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Andreas Axén, Herbert Baumann, Enrique Carredano, Anna Grönberg, Elles Steensma
  • Use of urea variants as affinity ligands
    Publication number: 20060014735
    Abstract: The present invention relates to an IgG-binding compound, which more specifically has affinity for human IgGs of ?-type and functional derivatives thereof. More specifically, the compound according to the invention comprises an N,N-alkylated urea moiety located between an aromatic part and another part, which is a linear or cyclic substituted or unsubstituted aliphatic group. The compound binds to a pocket-shaped binding site present on all human IgG ?-Fabs, which site is located between the two domains (CH1 and CL) of its constant part. Accordingly, the compound according to the invention is a ligand for human IgGs of ?-type, and consequently, the invention also relates to a separation matrix for affinity chromatography, which matrix comprises said compound, as well as to other uses of the compound.
    Type: Application
    Filed: September 12, 2003
    Publication date: January 19, 2006
    Inventors: Andreas Axen, Herbert Baumann, Enrique Carredano, Anna Gronberg, Elles Steensma