Patents by Inventor Elliot Androphy

Elliot Androphy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS FOR USE IN SCREENING METHODS FOR SPINAL MUSCULAR ATROPHY
    Publication number: 20160052935
    Abstract: Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.
    Type: Application
    Filed: November 10, 2015
    Publication date: February 25, 2016
    Inventors: Elliot Androphy, Gregory D. Cuny, Jonathan Cherry, Marcie A. Glicksman
  • Screening methods for spinal muscular atrophy
    Patent number: 9212209
    Abstract: Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: December 15, 2015
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Elliot Androphy, Gregory D. Cuny, Jonathan Cherry, Marcie A. Glicksman
  • SCREENING METHODS FOR SPINAL MUSCULAR ATROPHY
    Publication number: 20140193906
    Abstract: Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.
    Type: Application
    Filed: July 12, 2013
    Publication date: July 10, 2014
    Inventors: Elliot Androphy, Gregory D. Cuny, Jonathan Cherry, Marcie A. Glicksman
  • Spinal Muscular Atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences
    Publication number: 20070292408
    Abstract: The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and methods of the instant invention include oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target the SMN2 ISS-N1 site in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The ISS-N1 blocking agents of the invention cause elevated expression of SMN protein, thus compensating for the loss of SMN protein expression commonly observed in subjects with spinal muscular atrophy (SMA).
    Type: Application
    Filed: December 5, 2005
    Publication date: December 20, 2007
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Ravindra Singh, Natalia Singh, Nirmal Singh, Elliot Androphy
  • Compounds for treating human papillomavirus
    Publication number: 20050250855
    Abstract: Methods and compositions for treating human papillomavirus infections are described.
    Type: Application
    Filed: April 7, 2005
    Publication date: November 10, 2005
    Inventors: Elliot Androphy, James Baleja
  • E6 binding proteins
    Patent number: 5821051
    Abstract: An assay for screening test compounds to indentify agents which modulate the binding of an E6-BP polypeptide with a papilloma virus E6 protein. The assay includes combining, as a cell-free system, an E6-binding protein or fragment thereof which binds to the E6 protein, and a test compound, and detecting the formation of a complex which includes the E6 protein and the E6-binding protein. A change in the formation of the complex in the presence of the test compound is indicative of an agent that modulates interaction between an E6 and an E6-binding protein.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: October 13, 1998
    Assignee: New England Medical Center Hospitals
    Inventors: Elliot Androphy, Jason J. Chen