Patents by Inventor Elliot D. Rosen

Elliot D. Rosen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombianant Hepatitis a virus
    Patent number: 5294548
    Abstract: The present invention is directed to genetically engineered expression systems which encode a recombinant Hepatitis A virus (HAV) proteins capable of forming capsid particles. By way of example baculovirus vectors were utilized in order to express recombinant HAV proteins. The recombinant baculoviruses of the invention are formed by replacing regions of the polyhedrin structural gene coding sequences with HAV DNA by recombinant DNA techniques. Additionally, the polyhedrin transcriptional initiation site is altered in these recombinant baculoviruses such that only HAV proteins and not polyhedrin protein sequences are expressed from the polyhedrin promoter. The recombinant HAV capsid particles produced in accordance with the present invention can be particularly useful as vaccines.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: March 15, 1994
    Assignees: American Biogenetic Sciences, Inc, University of Iowa Research Foundation
    Inventors: James H. McLinden, Elliot D. Rosen, Patricia L. Winokur, Jack T. Stapleton
  • Heliothis expression systems
    Patent number: 5041379
    Abstract: The present invention relates to recombinant vector/host systems which can direct the expression of foreign genes under the control of the Heliothis polyhedrin promoter. Using the systems of the present invention, a heterologous gene of interest can be expressed as an unfused peptide or protein, a fusion protein, or as a recombinant occlusion body which comprises crystallized polyhedrin fusion proteins bearing the heterologous gene product on the surface of or within the occlusion body. The recombinant proteins or occlusion bodies of the present invention have uses in vaccine formulations and immunoassays, as biological insecticides, and as expression systems for the production of foreign peptides or proteins.
    Type: Grant
    Filed: March 14, 1988
    Date of Patent: August 20, 1991
    Assignee: American Biogenetic Science, Inc.
    Inventors: Malcolm J. Fraser, Elliot D. Rosen, Victoria A. Ploplis
  • Recombinant baculovirus occlusion bodies in vaccines and biological insecticides
    Patent number: 4870023
    Abstract: The present invention is directed to recombinant baculoviruses which encode fusion polyhedrin proteins capable of forming occlusion bodies containing foreign peptides. The recombinant baculoviruses of the invention are formed by insertion into or replacement of regions of the polyhedrin gene that are not essential for occlusion body formation, with foreign DNA fragments by recombinant DNA techniques. The recombinant occlusion bodies produced in accordance with the present invention have uses in vaccine formulations, immunoassays, immobilized enzyme reactions, as biological insecticides, and as expression vectors.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: September 26, 1989
    Assignee: American Biogenetic Sciences, Inc.
    Inventors: Malcolm J. Fraser, Elliot D. Rosen, Victoria A. Ploplis