Abstract: A sensor may include a housing configured to couple to a machine; at least one processor within the housing; a battery within the housing; a communication adapter within the housing and coupled to the at least one processor; and a measurement device within the housing and coupled to the at least one processor and the battery. The communication adapter may be configured to wirelessly connect to a communication network. The measurement device may be configured to: obtain measurements of a physical characteristic of the machine to which the housing is coupled and transmit the measurements via the communication adapter, and automatically switch between a first measurement mode comprising a first sampling rate and a second measurement mode comprising a second sampling rate, different from the first sampling rate, without human intervention.

Abstract: A sensor may include a housing configured to couple to a machine; at least one processor within the housing; a battery within the housing; a communication adapter within the housing and coupled to the at least one processor; and a measurement device within the housing and coupled to the at least one processor and the battery. The communication adapter may be configured to wirelessly connect to a communication network. The measurement device may be configured to: obtain measurements of a physical characteristic of the machine to which the housing is coupled and transmit the measurements via the communication adapter, and automatically switch between a first measurement mode comprising a first sampling rate and a second measurement mode comprising a second sampling rate, different from the first sampling rate, without human intervention.

Abstract: Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.

Abstract: Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group, and end-capped forms ranging in ratios from 100/0 to 1/99.

Abstract: Biodegradable pharmaceutical compositions and method for treating bacterial infections therein.

Abstract: Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group and end-capped forms ranging in ratios from 100/0 to 1/99.

Abstract: For use with a reserve battery couplable to a charging circuit capable of providing a charging current to the reserve battery, a mode selection circuit and a method of operation thereof. The mode selection circuit includes, in one embodiment, (1) a signal generator that generates a signal based on a temperature of the reserve battery and (2) a mode-changing circuit, coupled to the signal generator, that accepts the signal and selects an alternative one of: (a) a non-charge mode in which the charging current is substantially interrupted when the temperature is greater than a reference temperature and (b) a charge mode in which the charging current is provided to the reserve battery when the temperature is less than the reference temperature.

Abstract: For use with a reserve battery couplable to a charging circuit capable of providing a charging current to the reserve battery, a mode selection circuit and a method of operation thereof. The mode selection circuit includes, in one embodiment, (1) a signal generator that generates a signal based on a temperature of the reserve battery and (2) a mode-changing circuit, coupled to the signal generator, that accepts the signal and selects an alternative one of: (a) a non-charge mode in which the charging current is substantially interrupted when the temperature is greater than a reference temperature and (b) a charge mode in which the charging current is provided to the reserve battery when the temperature is less than the reference temperature.

Abstract: Apparatus and methods for dispensing medicinals encapsulated in a biodegrble polymer in surgical and other wounds are described. The apparatus, a microcapsule drug applicator, allows the caregiver to implant or spread measured and uniform quantities of microencapsulated medicinals in or on surgical or traumatic wounds to prevent and/or treat infections. Specific examples where microencapsulated antibiotics may prove useful include, soft-tissue wounds, following debridement and reduction or fixation of open fractures, to osteomyelitic bone after surgical debridement, after surgical insertion of prostheses such as hip/knee replacements (arthroplasty), and following vascular surgery or grafting.