Patents by Inventor Elliot V. Plotkin
Elliot V. Plotkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7807031Abstract: An improved disposable glucose test strip for use in a test meter of the type which receives a disposable test strip and a sample of blood from a patient and performs an electrochemical analysis is made using a non-conductive integrated reagent/blood separation layer containing a filler, an enzyme effective to oxidize glucose, e.g., glucose oxidase, and a mediator effective to transfer electrons from the enzyme. The integrated layer formulation is printed over a conductive carbon element to form a working electrode. The filler, for example a silica filler, is selected to have a balance of hydrophobicity and hydrophilicity such that one drying it forms a two-dimensional network on the surface of the conductive element. The response of this test strip is essentially temperature independent over relevant temperature ranges and is substantially insensitive to the hematocrit of the patient.Type: GrantFiled: June 13, 2006Date of Patent: October 5, 2010Assignee: Diabetes Diagnostics, Inc.Inventors: Jerome F. McAleer, Manuel Alvarez-Icaza, Geoff Hall, Elliot V. Plotkin, David Scott, Oliver W. H. Davies
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Patent number: 7112265Abstract: An improved disposable glucose test strip for use in a test meter of the type which receives a disposable test strip and a sample of blood from a patient and performs an electrochemical analysis using a non-conductive integrated reagent/blood separation layer (17) containing a filler, an enzyme effective to oxidize glucose, e.g., glucose oxidase, and a mediator effective to transfer electrons from the enzyme. The integrated layer formulation is printed over a conductive carbon element (16) to form a working electrode. The filler, for example a silica filler, is selected to have a balance of hydrophobicity such that on drying it forms a two-dimensional network on the surface of the conductive element. The response of this test strip is essentially temperature independent over relevant temperature ranges and is substantially insensitive to the hematocrit of the patient.Type: GrantFiled: January 11, 2000Date of Patent: September 26, 2006Assignee: Lifescan Scotland LimitedInventors: Jerome F. McAleer, Manuel Alvarez-Icaza, Geoff Hall, Elliot V. Plotkin, David Scott, Oliver W. H. Davies
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Patent number: 6241862Abstract: An improved disposable glucose test strip for use in a test meter of the type which receives a disposable test strip and a sample of blood from a patient and performs an electrochemical analysis is made using a non-conductive integrated reagent/blood separation layer containing a filler, an enzyme effective to oxidize glucose, e.g., glucose oxidase, and a mediator effective to transfer electrons from the enzyme. The integrated layer formulation is printed over a conductive carbon element to form a working electrode. The filler, for example a silica filler, is selected to have a balance of hydrophobicity and hydrophilicity such that one drying it forms a two-dimensional network on the surface of the conductive element. The response of this test strip is essentially temperature independent over relevant temperature ranges and is substantially insensitive to the hematocrit of the patient.Type: GrantFiled: January 12, 1999Date of Patent: June 5, 2001Assignee: Inverness Medical Technology, Inc.Inventors: Jerome F. McAleer, Manuel Alvarez-Icaza, Geoff Hall, Elliot V. Plotkin, David Scott, Oliver W. H. Davies
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Patent number: 5951836Abstract: An improved disposable glucose test strip for use in a test meter of the type which receives a disposable test strip and a sample of blood from a patient and performs an electrochemical analysis is made using a working formulation containing a filler, an enzyme effective to oxidize glucose, e.g., glucose oxidase, and a mediator effective to transfer electrons from the enzyme. The working formulation is printed over a conductive carbon base layer to form a working electrode. The filler, for example a silica filler, is selected to have a balance of hydrophobicity and hydrophilicity such that one drying it forms a two-dimensional network on the surface of the conductive base layer. The response of this test strip is essentially temperature independent over relevant temperature ranges and is substantially insensitive to the hematocrit of the patient.Type: GrantFiled: January 12, 1998Date of Patent: September 14, 1999Assignee: Selfcare, Inc.Inventors: Jerome F. McAleer, David Scott, Geoff Hall, Manuel Alvarez-Icaza, Elliot V. Plotkin
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Patent number: 5708247Abstract: An improved disposable glucose test strip for use in a test meter of the type which receives a disposable test strip and a sample of blood from a patient and performs an electrochemical analysis is made using a working formulation containing a filler, an enzyme effective to oxidize glucose, e.g., glucose oxidase, and a mediator effective to transfer electrons from the enzyme. The working formulation is printed over a conductive carbon base layer to form a working electrode. The filler, for example a silica filler, is selected to have a balance of hydrophobicity and hydrophilicity such that one drying it forms a two-dimensional network on the surface of the conductive base layer. The response of this test strip is essentially temperature independent over relevant temperature ranges and is substantially insensitive to the hematocrit of the patient.Type: GrantFiled: February 14, 1996Date of Patent: January 13, 1998Assignee: Selfcare, Inc.Inventors: Jerome F. McAleer, David Scott, Geoff Hall, Manuel Alvarez-Icaza, Elliot V. Plotkin
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Patent number: 4711245Abstract: This invention relates to equipment and methods for detecting the presence of, measuring the amount of, and/or monitoring the level of, one or more selected components in a liquid mixture, employing an electrode sensing system.We have discovered that a class of mediating compounds has extremely useful properties for mediating the transfer of charge between enzyme-catalyzed reactions and electrode surfaces (15) in electrode sensing systems.Specifically, the specification discloses as electrode sensor mediators, organometallic compounds composed of at least two organic rings, each of which has at least two double bonds in a conjugated relationship; a metal atom is in electron-sharing contact with those rings.Type: GrantFiled: May 7, 1984Date of Patent: December 8, 1987Assignee: Genetics International, Inc.Inventors: Irving J. Higgins, Hugh A. O. Hill, Elliot V. Plotkin
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Patent number: 4545382Abstract: A sensor electrode to detect one or more components in a liquid mixture comprises an electrically conductive material having at least an an external surface, the combination of an enzyme catalytic for a reaction of the desired component, and a mediator compound which transfers electrons from the enzyme to the electrode when such catalytic activity takes place. It can be used as an in vivo glucose sensor either with a silver electrode coated with e.g. glucose oxidase and a polyviologen as the mediators, or with a particulate carbon electrode, glucose oxidase and chloranil or fluoranil as mediator. Another system is to use bacterial glucose dehydrogenase or glucose oxidase as the enzyme and/or ferrocene or a ferrocene derivative as the mediators compound to give electrodes with improved linearity, speed of response and insensitivity to oxygen.Type: GrantFiled: October 22, 1982Date of Patent: October 8, 1985Assignee: Genetics International, Inc.Inventors: Irving J. Higgins, Hugh A. O. Hill, Elliot V. Plotkin