Abstract: An endovascular device includes a thin film polymer strip having an electrode array. The thin film polymer strip includes a thin film polymer shaped into a strip having a distal end and a proximal end and a plurality of exposed metal electrodes positioned at the distal end of the thin film polymer. Each metal electrode is composed of a metal film. The thin film polymer strip also includes a plurality of bond pads positioned at the proximal end of the thin film polymer. A plurality of insulated traces connect each electrode to a single bond pad. The thin film polymer strip also includes insulated micro-wires connected to bond pads and recording or stimulation equipment. Characteristically, the thin film polymer strip has a helical or cylindrical shape configured to fit around a commercial vascular guide wire.

Abstract: A flexible implantable electrode array is disclosed, comprising: a shank formed from a flexible polymer material. In an example embodiment, the shank comprises: a waveguide; and a number of chipsets disposed in the shank along the length of the shank, wherein each chipset is configured to measure neural activity in tissue surrounding the shank near the respective chipset, and to communicate signals representative of the measured neural activity via the waveguide. A method for powering and receiving neuronal information from a flexible implantable electrode array comprises: wirelessly communicating power and commands from a backplane to a plurality of chipsets disposed along the length of a shank via a waveguide disposed within the shank; monitoring neural activity proximate each chipset and sending a signal representative of said neural activity from the corresponding chipset transceiver to the backplane via the waveguide.

Abstract: A multi-sensor system may include a catheter that has lumen, is flexible, is made of a polymer, and has a circular cross section that has an outer diameter of no more than 0.5 cm; and one or more sensors that sense multiple characteristics of material flowing within the lumen, including at least two of the following: flow rate, pressure, and composition of the material. A multi-sensor system may include a catheter that has lumen, is flexible, is made of a polymer, and has a circular cross section that has an outer diameter of no more than 0.5 cm; and one or more sensors that sense multiple characteristics of material flowing within the lumen, including at least two of the following: flow rate, pressure, and composition of the material.

Abstract: A new class of peripheral nerve interfaces that combines microfluidics with microelectronics. A peripheral nerve interface that allows intraneural targeting through the combined use and sequential application of lysing agents and neurotrophic factors.

Abstract: A new class of peripheral nerve interfaces that combines microfluidics with microelectronics. A peripheral nerve interface that allows intraneural targeting through the combined use and sequential application of lysing agents and neurotrophic factors.

Abstract: A self-monitoring catheter system may detect an obstruction during use of a catheter. The system may include a catheter with an interior lumen that has one or more ports into the lumen; a first and a second electrode; and an impedance measurement instrument that measures changes in the impedance between the first and the second electrodes after the first electrode is exposed to fluid within the catheter lumen, thereby signaling an obstruction during use of the catheter.

Abstract: A self-monitoring catheter system may detect an obstruction during use of a catheter. The system may include a catheter with an interior lumen that has one or more ports into the lumen; a first and a second electrode; and an impedance measurement instrument that measures changes in the impedance between the first and the second electrodes after the first electrode is exposed to fluid within the catheter lumen, thereby signaling an obstruction during use of the catheter.

Abstract: Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. When a predetermined cracking pressure is reached, a valve opens and allows the liquid to flow through the cannula.

Abstract: Electrochemical impedance may be used for accurate and real-time tracking and control of fluid delivery from fluid-filled chambers, such as from drug delivery devices. At least two measurement electrodes may be placed within the chamber in contact with the fluid to be sensed. Application of a small alternating current using these electrodes through the fluid/drug may allow measurement of electrochemical impedance. Volumetric changes of the compressible chamber due to movement of at least one surface within the compressible chamber (such as an actuating bellows or flexible diaphragm), may induce changes in the measured electrochemical impedance. Measuring these changes may allow for tracking of ejected liquid volumes from the compressible chamber. By taking the time-derivative of this signal, the rate of volume change can be tracked and therefore the rate of ejected fluid (flow rate) can be deduced.

Abstract: An implantable fluid delivery system may include a fluid reservoir configured to hold a supply of fluid, dispense that fluid under the control of an actuator, and be implanted within the body of a living host. The actuator may include a bellows configured to expand in a direction when inflated. The bellows may have folds with surfaces which run substantially perpendicular to the direction of expansion in a collapsed state and which define a stacked set of convolutions. Each convolution may have a collapsed height of no more than 1 mm and a width perpendicular to the direction of expansion of no more than 8 mm. Electrodes may be configured to come in electrical contact with an electrolyte within the bellows and to cause electricity to run through the electrolyte, thereby causing the electrolyte to break down into a gas and, in turn, to cause the bellows to expand.

Abstract: Provided is a micro electro mechanical systems (MEMS) device for use with an elongate structure. The MEMS device includes a generally planar substrate, a device wall layer formed upon the substrate, a septum cavity formed in the device wall layer, a channel formed in the device wall layer in fluid communication with the septum cavity, and a septum element disposed in the septum cavity. The septum element is formed of a viscoelastic material. The septum element defines a septum entry surface and a septum exit surface with the septum exit surface being exposed to the channel and disposed between the septum entry surface and the channel. The septum element is without any openings formed through the septum element extending between the septum entry and exit surfaces. Methods of manufacturing and interacting with the MEMS device are also provided.

Abstract: A pressure transducer for measuring pressure may include an all-polymer chamber that has no dimension greater than 1 mm. There may be fluid within the chamber, a gaseous bubble trapped within the fluid, and electrodes in contact with the fluid. The electrodes may enable a measurement of changes in the impedance of the fluid caused by changes in the volume of the gaseous bubble caused by changes in the pressure to be measured. The pressure transducer may be made by depositing the chamber, placing the fluid within the chamber, and generating the gaseous bubble within the fluid with electrolysis.

Abstract: A drug delivery device may include a drug reservoir configured to contain and controllably deliver a fluidic drug. A tube may be configured to deliver the fluid from the drug reservoir through a lumen in the tube to another location. A valve wholly within the lumen of the tube may regulate the flow of the fluid through the tube without substantially diverting the direction in which the fluid flows through the tube. The valve may contain only a single member which moves during operation of the valve. The valve may be configured to regulate the flow of fluid in a bandpass manner by allowing fluid to flow through the valve only when the pressure of the fluid is above a minimum and below a maximum. The valve may be held in place within the tube solely by frictional force between the valve and a wall of the tube.

Abstract: Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball.

Abstract: Electrochemical impedance may be used for accurate and real-time tracking and control of fluid delivery from fluid-filled chambers, such as from drug delivery devices. At least two measurement electrodes may be placed within the chamber in contact with the fluid to be sensed. Application of a small alternating current using these electrodes through the fluid/drug may allow measurement of electrochemical impedance. Volumetric changes of the compressible chamber due to movement of at least one surface within the compressible chamber (such as an actuating bellows or flexible diaphragm), may induce changes in the measured electrochemical impedance. Measuring these changes may allow for tracking of ejected liquid volumes from the compressible chamber. By taking the time-derivative of this signal, the rate of volume change can be tracked and therefore the rate of ejected fluid (flow rate) can be deduced.

Abstract: Provided is a micro electro mechanical systems (MEMS) device for use with an elongate structure. The MEMS device includes a generally planar substrate, a device wall layer formed upon the substrate, a septum cavity formed in the device wall layer, a channel formed in the device wall layer in fluid communication with the septum cavity, and a septum element disposed in the septum cavity. The septum element is formed of a viscoelastic material. The septum element defines a septum entry surface and a septum exit surface with the septum exit surface being exposed to the channel and disposed between the septum entry surface and the channel. The septum element is without any openings formed through the septum element extending between the septum entry and exit surfaces. Methods of manufacturing and interacting with the MEMS device are also provided.

Abstract: Provided is a micro electro mechanical systems (MEMS) device for use with an elongate structure. The MEMS device includes a generally planar substrate, a device wall layer formed upon the substrate, a septum cavity formed in the device wall layer, a channel formed in the device wall layer in fluid communication with the septum cavity, and a septum element disposed in the septum cavity. The septum element is formed of a viscoelastic material. The septum element defines a septum entry surface and a septum exit surface with the septum exit surface being exposed to the channel and disposed between the septum entry surface and the channel. The septum element is without any openings formed through the septum element extending between the septum entry and exit surfaces. Methods of manufacturing and interacting with the MEMS device are also provided.

Abstract: Embodiments of the present disclosure are directed to MEMS-based medical devices including a flexible housing that forms a chamber for encapsulating a fluid or liquid. The devices also include encapsulated electrodes, portions of which are exposed to the fluid or liquid within the chamber for sensing and/or physical actuation (controlled movement). Such medical devices can function specifically as: contact force sensors; and/or out-of-plane actuators. Device function is enabled by the encapsulation of liquid within the microchamber. Depending on the kind of electrical input applied, the encapsulated electrodes can function as electrochemical sensing elements; and/or electrolytic generation electrodes. Devices according to the present disclosure can have a fluidic coupling to the external environment or can be isolated. Fluidic isolation from the surrounding environment can be accomplished by the inclusion of an annular-plate stiction valve within the device.

Abstract: A pressure transducer for measuring pressure may include an all-polymer chamber that has no dimension greater than 1 mm. There may be fluid within the chamber, a gaseous bubble trapped within the fluid, and electrodes in contact with the fluid. The electrodes may enable a measurement of changes in the impedance of the fluid caused by changes in the volume of the gaseous bubble caused by changes in the pressure to be measured. The pressure transducer may be made by depositing the chamber, placing the fluid within the chamber, and generating the gaseous bubble within the fluid with electrolysis.

Abstract: Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. A valve for maintaining a constant flow rate through the cannula independent of the pressure applied to the device may be included.