Patents by Inventor Elmar Heinzle
Elmar Heinzle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8148117Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.Type: GrantFiled: October 23, 2006Date of Patent: April 3, 2012Assignee: Evonik Degussa GmbHInventors: Oskar Zelder, Andrea Herold, Corinna Klopprogge, Hartwig Schröder, Stefan Haefner, Elmar Heinzle, Christoph Wittmann, Jens Kroemer, Janice G. Pero, R. Rogers Yocum, Thomas A. Patterson, Mark Williams, Theron Herman
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Patent number: 8048651Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.Type: GrantFiled: July 31, 2009Date of Patent: November 1, 2011Assignee: BASF SEInventors: Oskar Zelder, Corinna Klopprogge, Hartwig Schroder, Stefan Haefner, Burkhard Kröger, Patrick Kiefer, Elmar Heinzle, Christoph Wittmann
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Publication number: 20100015674Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.Type: ApplicationFiled: July 31, 2009Publication date: January 21, 2010Applicant: BASF SEInventors: Oskar Zelder, Corinna Klopprogge, Hartwig Schroder, Stefan Häfner, Burkhard Kröger, Patrick Kiefer, Elmar Heinzle, Christoph Wittmann
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Publication number: 20100009416Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-methionine. In particular, the present invention relates to processes in which the amount of serine available for the metabolism of the microorganism is increased.Type: ApplicationFiled: May 24, 2007Publication date: January 14, 2010Inventors: Oskar Zelder, Andrea Herold, Corinna Klopprogge, Hartwig Schröder, Elmar Heinzle, Christoph Wittmann, Jens Kroemer, Janice Pero, Rogers Yocum, Thomas Patterson, Mark Williams, Theron Hermann
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Publication number: 20090298137Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.Type: ApplicationFiled: October 23, 2006Publication date: December 3, 2009Applicant: BASF AGInventors: Oskar Zelder, Andreas Herold, Corinna Klopprogge, Hartwig Schröder, Stefan Haefner, Elmar Heinzle, Christoph Wittmann, Jens Kroemer, Janice G. Pero, R. Rogers Yocum, Thomas A. Patterson, Mark Williams, Theron Herman
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Publication number: 20090191610Abstract: The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.Type: ApplicationFiled: August 18, 2006Publication date: July 30, 2009Applicant: Evonik Degussa GmbHInventors: Oskar Zelder, Andrea Herold, Corinna Klopprogge, Hartwig Schroder, Stefan Haefner, Elmar Heinzle, Christoph Wittmann, Jens Kroemer, Janice G. Pero, R. Rogers Yocum, Thomas A. Patterson, Mark Williams, Theron Herman
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Patent number: 7445885Abstract: A process is described for analyzing enzyme-catalyzed conversions of nonpolymeric substrates to nonpolymeric products with the aid of MALDI-TOF mass spectrometry, preferably in the presence of an internal standard on a specific carrier material.Type: GrantFiled: June 6, 2001Date of Patent: November 4, 2008Assignee: BASF AktiengesellschaftInventors: Elmar Heinzle, Min-Jung Kang, Andreas Tholey, Klaus Hollemeyer, Bernhard Hauer
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Publication number: 20080160585Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.Type: ApplicationFiled: January 28, 2008Publication date: July 3, 2008Applicant: BASF AktiengesellschaftInventors: Oskar Zelder, Corinna Klopprogge, Hartwig Schroder, Stefan Hafner, Burkhard Kroger, Patrick Kiefer, Elmar Heinzle, Christoph Wittmann
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Publication number: 20080038787Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i. e., glycerol kinase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of glycerol kinase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.Type: ApplicationFiled: December 17, 2004Publication date: February 14, 2008Applicant: Basf AktiengesellschaftInventors: Oskar Zelder, Corinna Klopprogge, Hartwig Schroder, Stefan Hafner, Burkhard Kroger, Patrick Kiefer, Elmar Heinzle, Christoph Wittmann
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Publication number: 20080032374Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.Type: ApplicationFiled: December 17, 2004Publication date: February 7, 2008Applicant: Basf AktiengesellschaftInventors: Oskar Zelder, Corinna Klopprogge, Hartwig Schroder, Stefan Hafner, Burkhard Kroger, Patrick Kiefer, Elmar Heinzle, Christoph Wittmann
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Publication number: 20070134768Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., lactate dehydrogenase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of the expression of lactate dehydrogenase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.Type: ApplicationFiled: December 17, 2004Publication date: June 14, 2007Applicant: BASF AktiengesellschaftInventors: Oskar Zelder, Corinna Klopprogge, Hartwig Schroder, Stefan Hafner, Burkhard Kroger, Patrick Kiefer, Elmar Heinzle, Christoph Wittmann
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Publication number: 20040142383Abstract: A method for determining genus, species, race and/or geographical origin of biological materials, by directly cleaving with enzymatic methods the fibrillary structures such as feathers, down, hair or horn to form a pool of cleaved peptides, without prior dissolution of structure proteins; and wherein the pool of cleaved peptides obtained from fibillary structure proteins is preferably subjected to MALDI-TOF mass spectroscopy without the application of separating and isolating techniques, and wherein the mass spectrograms obtained are adjusted using reference mass spectrograms and the suitable specific mass peaks are used to quantify elements such as feathers, down, scales horn and/or hair which are foreign to the species.Type: ApplicationFiled: November 14, 2003Publication date: July 22, 2004Inventors: Wolfgang Altmeyer, Klaus Hollemeyer, Elmar Heinzle, Heiko Ewen
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Publication number: 20030164449Abstract: A process is described for analyzing enzyme-catalyzed conversions of nonpolymeric substrates to nonpolymeric products with the aid of MALDI-TOF mass spectrometry, preferably in the presence of an internal standard on a specific carrier material.Type: ApplicationFiled: November 25, 2002Publication date: September 4, 2003Inventors: Elmar Heinzle, Min-Jung Kang, Andreas Tholey, Klaus Hollemeyer, Bernhard Hauer
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Patent number: 4140741Abstract: The use of cyclic carbonic acid esters of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, are hydrogen or alkyl with 1 to 6 C-atoms, as a solvent for racemic or optically active poly-(.beta.-hydroxybutyric acid).The preferred embodiment uses hot (120 to 150.degree. C) ethylene carbonate or 1,2-propylene carbonate to extract poly-(.beta.-hydroxybutyric acid) from moist or dry fermentation masses. These solvents have the advantage that the extracted poly-(.beta.-hydroxybutyric acid) is precipitated in good yield from them on cooling. In addition they may be recycled without the need for a solvent regeneration step. These cyclic carbonic acid esters may also be used as the solvent in the processing of poly-(.beta.-hydroxybutyric acid) by e.g. wet spinning.Type: GrantFiled: January 12, 1978Date of Patent: February 20, 1979Assignee: Agroferm A.G.Inventors: Robert M. Lafferty, Elmar Heinzle
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Patent number: 4101533Abstract: The use of cyclic carbonic acid esters of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, are hydrogen or alkyl with 1 to 6 C-atoms, as a solvent for racemic or optically active poly-(.beta.-hydroxybutyric acid).The preferred embodiment uses hot (120.degree. to 150.degree. C) ethylene carbonate or 1,2-propylene carbonate to extract poly-(.beta.-hydroxybutyric acid) from moist or dry fermentation masses. These solvents have the advantage that the extracted poly-(.beta.-hydroxybutyric acid) is precipitated in good yield from them on cooling. In addition they may be recycled without the need for a solvent regeneration step. These cyclic carbonic acid esters may also be used as the solvent in the processing of poly-(.beta.-hydroxybutyric acid) by e.g. wet spinning.Type: GrantFiled: January 12, 1977Date of Patent: July 18, 1978Assignee: Agroferm AGInventors: Robert M. Lafferty, Elmar Heinzle