Abstract: The invention concerns a Proteolysis Targeting Chimera (PROTAC) or a pharmaceutically acceptable salt thereof for degradation of Aurora A-kinase in cells of a mammal which PROTAC has the chemical structure AAB-L-E3B, wherein AAB is a binding unit for Aurora A-kinase, L is a linker and E3B is a binding unit for E3-ubiquitin ligase Cereblon, wherein E3B comprises the structure of thalidomide or of one of its analogs lenalidomide, pomalidomide, and apremilast, wherein L comprises or consists of an alkyl ether residue or a polyalkyl ether residue or an alkyl ether residue or a polyalkyl ether residue in which at least one C—C bond is replaced by a C?C double bond, which polyalkyl ether residue has at least two ether groups or at least two ether groups in which one O-atom is replaced by an S-atom or a part of the O-atoms is replaced by S-atoms or wherein L comprises or consists of an alkyl thioether residue or a polyalkyl thioether residue or an alkyl thioether residue or a polyalkyl thioether residue in which at

Abstract: Process for the preparation of (cyclo)aliphatic uretdiones of improved color quality by reaction of (cyclo)aliphatic diisocyanates, if desired in an inert solvent, with the aid of from 0.5 to 3% by weight of a catalyst of formula (I) in the presence of from 0.

Abstract: Partially or completely blocked polyisocyanates having an built-in HALS stabilizer.

Abstract: Moisture-crosslinking PU hot-melt adhesives produced by reacting an --NCO containing prepolymer and a sterically hindered polyamine which have a very high initial strength.

Abstract: Partially or completely blocked polyisocyanates having a built-in HALS stabilizer.

Abstract: A process for the preparation of an isocyanurate-free uretdione of isophorphone diisocyanate, comprising dimerizing an isophorone diisocyanate of the general formula: ##STR1## in an inert organic solvent or in the absence of a solvent, with the aid of a catalysts, at a temperature of 0 to 80.degree. C.; isolating the uretdione formed from the reaction mixture after a conversion of 5-70%, without prior deactivation of the catalyst, by thin film distillation at 100-180.degree. C. under 0.01-0.5 mbar; wherein the isophorone diisocyanate has a purity of .gtoreq.99.9% by weight, and the concentration of the unknown first runnings component in a gas chromatogram of the isophorone diisocyanate employed for the dimerization is not greater than 0.05 area%; and wherein R.sup.1 and R.sup.2 are identical or different alkyl radicals having 1-8 C atoms, or with the N atom bonded to the ring, can form a common 5- or 6-membered ring which can contain a CH--CH.sub.3 group, an N--CH.sub.3 group or an O atom instead of a CH.

Abstract: A power coating and a substrate coated with the coating are provided, wherein the coating contains a mixture ofA) a pulverulent polyisocyanate component which is a solid at temperatures of less than 50.degree. C. and a liquid at temperatures above 160.degree. C., of the formula I ##STR1## where R, R.sup.1 and n are as described herein, and B) a pulverulent, organic polyhydroxy component which is a solid at temperatures of less than 50.degree. C. and a liquid at temperatures above 160.degree. C. and having a ratio of secondary to primary OH groups of at least 3.1,wherein components A and B are present in a ratio of equivalents of NCO:OH groups of from 0.5:1 to 1.3:1,and wherein component B is selected from the group consisting of bisphenol A-containing epoxy resin, oligoamides containing secondary hydroxyl groups, and mixtures thereof.

Abstract: A Polyaddition product, containing uretdione groups, which is obtainable by reaction of (A) a diisocyanate mixture which contains uretdione groups and comprises (1) at least 40 mol % to not more than 80 mol % of isophorone diisocyanate containing uretdione groups and (2) not more than 60 mol % and not less than 20 mol % of hexamethylene diisocyanate containing uretdione groups, with (B) a disecondary diamine, in an NCO/NH ratio of 1:0.5 to 1:0.9 at room temperature to 60.degree. C. in a solvent which is inert towards isocyanates.

Abstract: Uretdione-functional polyaddition compounds of the formula: ##STR1## Y and Y' are O, NH, or NR.sup.5 ; n is 1-20;R is ##STR2## R.sup.1 is a divalent hydrocarbon radical of 2-16 carbon atoms; R.sup.2 is H, identical or different hydrocarbon radicals of 1-14 carbon atoms;R.sup.3, R.sup.4 and R.sup.5 are identical or different hydrocarbon radicals of 1-14 carbon atoms, by reacting IPDI uretdione with at least one reactant selected from the group consisting of diols, amino alcohols and diamines in a solution (L1) thereby forming the product (UD-DA) polyaddition compound, and adding the solution (L1) to a second solvent (L2) in which the uretdione polyaddition compound is insoluble, thereby precipitating said polyaddition compound (UD-DA).

Abstract: Uretdione-functional polyaddition compounds of the formula: ##STR1## where: ##STR2## R.sup.1 is R or linear, branched or cyclic alkylene radicals of 2-16 carbon atoms,R.sup.2 and R.sup.3 are identical or different hydrocarbon radicals of 1-14 carbon atoms,R.sup.4 is R.sup.

Abstract: The invention relates to cold-curing, low-solvent or solvent-free 2-component polyurethane/polyurea compositions comprising a reaction product of:a) a diamine of the following composition ##STR1## where R is a linear, branched or cyclic alkylene radical having 2-16 carbon atoms which may be optionally substituted by C.sub.1 -C.sub.4 alkyl, wherein in said alkylene radical 1-3 CH.sub.2 groups may optionally be replaced by ##STR2## groups; and b) one or more NCO prepolymers prepared from reaction of one or more linear, branched or cyclic aliphatic isocyanates and one or more branched polyetherpolyols or polyesterpolyols, wherein the NCO prepolymer has an NCO functionality .gtoreq.2;wherein reactants a) and b) are reacted in an NCO:NH equivalent ratio of (1.5-1):1 and their use as coatings and reaction coating materials.

Abstract: Isocyanurate- and uretdione-group-containing polyaddition product of an isophorone diisocyanate comprising the reaction product of:i) an isophorone diisocyanate which contains isocyanurate groups and uretdione groups; andii) a diol component selected from the group consisting of a diol, a disecondary diamine, a linear hydroxyl-containing polyester and a mixture thereof,wherein said isophorone diisocyanate comprises not more than 2% by weight of free isophorone diisocyanate and .gtoreq.5 wt. % of isophorone diisocyanate isocyanurate,wherein said isophorone diisocyanate is reacted with said diol component in an NCO/OH ratio of 1:0.5-1:0.95 and/or an NCO/NH ratio of 0.5:1 0.95:1.

Abstract: A liquid one-component PU stoving enamel is provided along with its synthesis, where the stoving enamel containsa) a hydroxyl-containing polymer;b) a partially or totally blocked isophorone-based polyisocyanate containing uretdione groups;c) an organic bismuth compound catalyst, andd) an organic solvent or mixture of two or more organic solvents,wherein components a and b are present in a total (a+b) amount of from 40 to 70 parts by weight based on total composition weight, component c is present in an amount of from 0.5 to 5 parts by weight based on total composition weight; and component d is present in an amount of from 30 to 60 parts by weight based on total composition weight; andwherein a and b are each present in amounts sufficient to provide an OH/NCO equivalents ratio of from 0.8 to 1.2 NCO equivalents of component b per OH equivalent of component a.

Abstract: Polyamines containing tert-butyl (meth)acrylate groups and having the general formula I ##STR1## wherein R.sup.1 represents a (cyclo)alkylene radical having 2-14 carbon atoms, which may optionally be substituted by 1-3 CH.sub.3 or C.sub.2 H.sub.5 groups and 1-3 CH.sub.2 groups may be substituted by oxygen or --NH--, --NCH.sub.3 -- or --C(O)NH-- groups, R.sup.2 denotes hydrogen or methyl and x may be a number between 1 and 0 with the proviso that 2(1-x).gtoreq.0.1, are effective epoxy curing agents.

Abstract: A compound containing cyclic amidine groups and uretdione groups, having the formula: ##STR1## wherein X is O or NR.sup.2, R is the hydrocarbon radical of isophorone diisocyanate: ##STR2## R.sup.1 is a substituted (cyclo)alkylene radical which is substituted with O-3 CH.sub.3 groups and has 2-14 carbon atoms @R.sup.2 and R.sup.

Abstract: A flexible epoxy resin system is prepared by incorporating a combination of hardeners (A) and (B) in an epoxy resin, wherein the amounts of the two hardeners are varied to adjust the flexibility of the epoxy resin.

Abstract: Low-viscosity (cyclo)-aliphatic polyamines containing urea groups and having more than two amino groups may be prepared by reacting (cyclo)aliphatic diamines with polyisocyanates containing isocyanurate groups or biuret groups. Such polyamines are useful as components in PUR reaction finishes and coating and adhesive compositions.

Abstract: (Cyclo)aliphatic polyisocyanates are provided which are completely or partially blocked with malonic esters, the malonic ester containing at least one tert-butyl group. The blocked polyisocyanates may be deblocked at a reduced temperature.

Abstract: A curing agent for a composition useful for the production of matt epoxy resin and hybrid powder coatings, comprising a mixture ofa) salts of phthalic acid, isophthalic acid and terephthalic acid with the following amines ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 are identical or different aliphatic, cycloaliphatic, araliphatic or aromatic hydrocarbon radicals having 1-20 carbon atoms and in which one or more CH.sub.2 groups in the carbon chain may be replaced by 0 atoms, by NR.sub.4 groups where R.sub.4 =C.sub.1-6 -alkyl, CH--OH groups, and/or one or more terminal methyl groups may be replaced by dialkyl-substituted amino groups having 1 to 6 carbon atoms, and R.sub.1 and R.sub.2 may form a joint ring in which one CH.sub.2 group may be replaced by an O atom or by an NR.sub.4 group, and R.sub.1 =R.sub.2 =R.sub.3 --CH.sub.2 --CH.sub.2 -- attached via a common nitrogen atom, and n=3-11, and 0.5-2 mol of amine A)-C) per mole of acid, andb) pyromellitic acid and/or trimellitic acid, 0.