Abstract: A method for inhibiting device thrombosis for a patient may include circulating blood through an extracorporeal circuit coupled to the patient, infusing nitrite into the flow of blood such that the nitrite is bioactivated by red blood cells to form nitric oxide, and illuminating the flow of blood with far-red light to increase bioactivation of the nitrite by the red blood cells. A system for inhibiting device thrombosis for a patient may include an extracorporeal circuit configured to circulate a flow of blood, a nitrite infusion device coupled to the extracorporeal circuit and configured to infuse nitrite into the flow of blood, and one or more light sources disposed along the extracorporeal circuit and configured to illuminate the flow of blood with far-red light.