Patents by Inventor Elodie Crublet

Elodie Crublet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MGMT-based method for obtaining high yeilds of recombinant protein expression
    Patent number: 10017769
    Abstract: The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: July 10, 2018
    Assignee: INSTITUT PASTEUR
    Inventors: Philippe Despres, Sylvie Paulous, Elodie Crublet
  • MGMT-BASED METHOD FOR OBTAINING HIGH YEILDS OF RECOMBINANT PROTEIN EXPRESSION
    Publication number: 20170088843
    Abstract: The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.
    Type: Application
    Filed: December 13, 2016
    Publication date: March 30, 2017
    Applicant: INSTITUT PASTEUR
    Inventors: Philippe DESPRES, Sylvie PAULOUS, Elodie CRUBLET
  • MGMT-based method for obtaining high yields of recombinant protein expression
    Patent number: 9546380
    Abstract: The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: January 17, 2017
    Assignee: INSTITUT PASTEUR
    Inventors: Philippe Despres, Sylvie Paulous, Elodie Crublet
  • MGMT-BASED METHOD FOR OBTAINING HIGH YEILDS OF RECOMBINANT PROTEIN EXPRESSION
    Publication number: 20160017367
    Abstract: The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.
    Type: Application
    Filed: July 28, 2015
    Publication date: January 21, 2016
    Applicant: INSTITUT PASTEUR
    Inventors: Philippe DESPRES, Sylvie PAULOUS, Elodie CRUBLET
  • MGMT-based method for obtaining high yields of recombinant protein expression
    Patent number: 9109219
    Abstract: The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: August 18, 2015
    Assignee: INSTITUT PASTEUR
    Inventors: Philippe Despres, Sylvie Paulous, Elodie Crublet
  • MGMT-BASED METHOD FOR OBTAINING HIGH YEILDS OF RECOMBINANT PROTEIN EXPRESSION
    Publication number: 20130309747
    Abstract: The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.
    Type: Application
    Filed: December 9, 2011
    Publication date: November 21, 2013
    Inventors: Philippe Despres, Sylvie Paulous, Elodie Crublet