Patents by Inventor Else Frohlich

Else Frohlich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microfluidic tissue model
    Patent number: 10018620
    Abstract: The present disclosure describes systems and methods for mimicking body tissue and the function thereof. The mimicked body tissue can include kidney tissue, the blood brain barrier, and other tissues. In some implementations, the systems described herein are used to test the impact of controlled factors on the tissue. The controlled factors can include flow rates, shear rates, and test chemicals (e.g., therapeutics and toxins). In some implementations, the system and methods are used to test pharmaceutical and biological therapies, characterize healthy or diseased tissue, and observe phenomena of the tissue in vitro.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: July 10, 2018
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Joseph L. Charest, Else Frohlich, Christopher DiBiasio, Kenneth Vandevoordt
  • Systems, methods, and devices relating to a biomimetic cellularized nephron unit
    Patent number: 9657261
    Abstract: Disclosed herein are systems and devices for culturing cells in a biomimetic environment of a cellularized nephron unit, and methods for fabricating and using the cellularized nephron unit.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: May 23, 2017
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Joseph L. Charest, Else Frohlich, Jeffrey T. Borenstein
  • MICROFLUIDIC TISSUE MODEL
    Publication number: 20150301027
    Abstract: The present disclosure describes systems and methods for mimicking body tissue and the function thereof. The mimicked body tissue can include kidney tissue, the blood brain barrier, and other tissues. In some implementations, the systems described herein are used to test the impact of controlled factors on the tissue. The controlled factors can include flow rates, shear rates, and test chemicals (e.g., therapeutics and toxins). In some implementations, the system and methods are used to test pharmaceutical and biological therapies, characterize healthy or diseased tissue, and observe phenomena of the tissue in vitro.
    Type: Application
    Filed: April 16, 2015
    Publication date: October 22, 2015
    Inventors: Joseph L. Charest, Else Frohlich, Christopher DiBiasio, Kenneth Vandevoordt
  • SYSTEMS, METHODS, AND DEVICES RELATING TO A BIOMIMETIC CELLULARIZED NEPHRON UNIT
    Publication number: 20120318726
    Abstract: Disclosed herein are systems and devices for culturing cells in a biomimetic environment of a cellularized nephron unit, and methods for fabricating and using the cellularized nephron unit.
    Type: Application
    Filed: June 15, 2012
    Publication date: December 20, 2012
    Inventors: Joseph L. Charest, Else Frohlich, Jeffrey T. Borenstein
  • DEVICE AND METHOD FOR CULTURING CELLS IN A BIOMIMETIC ENVIRONMENT
    Publication number: 20120322097
    Abstract: Devices and methods are disclosed herein for a biomimetic flow apparatus. The biomimetic flow apparatus includes a microfluidic flow channel and an inlet in fluid connection with the flow channel for allowing fluid to flow into the flow channel. The flow channel has at least one surface with a topography formed therein. The topography of the at least one surface of the flow channel is selected to cause cells in a cell layer above the surface to achieve an arrangement, behavior, or morphology. The cell arrangement, behavior, or morphology is determined at least in part by the topography of the at least one surface.
    Type: Application
    Filed: June 15, 2012
    Publication date: December 20, 2012
    Inventors: Joseph L. Charest, Else Frohlich, Jeffrey T. Borenstein