Patents by Inventor Else Marit INDERBERG
Else Marit INDERBERG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230355672Abstract: Provided herein are proteins comprising a novel antigen binding domain. Said antigen binding domain, and proteins comprising it, are able to bind to osteosarcoma cells under physiological conditions. The antigen binding domain comprises an antibody light chain variable domain (VL) and an antibody heavy chain variable domain (VH), each comprising three complementarity determining regions (CDRs) flanked by human framework sequences. The human framework sequences reduces the risk of triggering unwanted immunogenic responses against the antigen binding domain. This may be especially important in a therapeutic setting wherein a drug is administered repeatedly to a human osteosarcoma patient.Type: ApplicationFiled: June 24, 2021Publication date: November 9, 2023Inventors: Sébastian Wälchli, Øyvind S. Bruland, Darragh McCann, Samantha Crawford, Else Marit Inderberg, Monica Berrondo, Susana Kaufmann, Jacob Byerly
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Publication number: 20230277641Abstract: A polypeptide comprising the sequence of SEQ. ID NO. 2, 3, 4, 7 or 8. The polypeptide may have the sequence of an immunogenic fragment thereof comprising at least eight amino acids, wherein the immunogenic fragment is not one of SEQ. ID NOS. 6 or 11 to 16. The polypeptide may have a sequence having at least 80% sequence identity to the aforementioned polypeptide or immunogenic fragment. The polypeptide is less than 100 amino acids in length and does not comprise the sequence of any of SEQ. ID NOS. 10, 46, 56, 57 or 59 to 62 and does not consist of the sequence of SEQ ID NO. 58. The polypeptide is useful in the treatment or prophylaxis of cancer.Type: ApplicationFiled: December 15, 2022Publication date: September 7, 2023Inventors: Gustav Gaudernack, Anne-Marie Rasmussen, Else Marit Inderberg Suso
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Publication number: 20230192804Abstract: The present invention provides a nucleic acid molecule encoding a specific binding molecule capable of binding an h TERT peptide comprising the amino acid sequence set forth in SEQ ID NO: 1 when the peptide is presented by a Class II Major Histocompatibility Complex (MHC), wherein the specific binding molecule comprises a first polypeptide comprising a variable region of an ?-chain and a second polypeptide comprising a variable region of a ?-chain of a T-cell receptor (TCR), and wherein: (a) the variable region of an ?-chain comprises CDR sequences CDR1, CDR2 and CDR3 which respectively comprise the amino acid sequences set forth in SEQ ID NOs: 2, 3 and 4; and (b) the variable region of a ?-chain comprises CDR sequences CDR1, CDR2 and CDR3 which respectively comprise the sequences set forth in SEQ ID NOs: 5, 6 and 7. Recombinant constructs, vectors and host cells comprising such nucleic acid molecules are also provided, as are specific binding molecules encoded by such nucleic acid molecules.Type: ApplicationFiled: February 27, 2019Publication date: June 22, 2023Inventors: Gustav GAUDERNACK, Gunnar KVALHEIM, Else Marit INDERBERG, Sébastien WÄLCHLI
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Patent number: 11529403Abstract: A polypeptide comprising the sequence of SEQ. ID NO. 2, 3, 4, 7 or 8. The polypeptide may have the sequence of an immunogenic fragment thereof comprising at least eight amino acids, wherein the immunogenic fragment is not one of SEQ. ID NOS. 6 or 11 to 16. The polypeptide may have a sequence having at least 80% sequence identity to the aforementioned polypeptide or immunogenic fragment. The polypeptide is less than 100 amino acids in length and does not comprise the sequence of any of SEQ. ID NOS. 10, 46, 56, 57 or 59 to 62 and does not consist of the sequence of SEQ ID NO. 58. The polypeptide is useful in the treatment or prophylaxis of cancer.Type: GrantFiled: April 27, 2017Date of Patent: December 20, 2022Assignee: ULTIMOVACS ASInventors: Gustav Gaudernack, Anne-Marie Rasmussen, Else Marit Inderberg Suso
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Publication number: 20220177573Abstract: The present disclosure relates to compositions comprising compounds or cells able to specifically bind immunoglobulin kappa (IgKappa) and membrane molecule CD 19 under physiological conditions. In particular, the disclosure relates to a combinatorial chimeric antigen receptor (cCAR) with antigen binding domains specific for the antigen CD19 and the immunoglobulin (Ig) Kappa light chain and their expression in immune effector cells to target cells expressing CD19 and IgKappa, and such immune cells for use in treating B-cell cancers.Type: ApplicationFiled: July 8, 2019Publication date: June 9, 2022Inventors: Gunnar Kvalheim, Erlend Smeland, Else Marit Inderberg, Sébastien Wälchli, Harald Holte, June Helen Myklebust, Steinar Funderud, Hakan Köksal
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Publication number: 20220175897Abstract: Novel chimeric antigen receptors (CARs) are provided. When the CARs herein are expressed on the surface of immune cells, such immune cells may be directed to osteosarcoma cells as demonstrated with our in vivo data. In a murine intraperitoneal model, the tumor growth was significantly delayed for T cells expressing a CAR comprising a scFv from TP1 or TP3 antibodies. Immune cells expressing the CARs herein display therapeutic effect in the form of decreased tumor volume in a murine model simulating metastatic osteosarcoma. Combined with the finding that stem cells from healthy bone marrow were not significantly affected by T cells expressing any of the CARs, this disclosure provides an attractive cell therapeutic alternative for treatment of osteosarcoma.Type: ApplicationFiled: December 19, 2019Publication date: June 9, 2022Inventors: Else Marit Inderberg, Sébastian Wälchli, Øyvind S. Bruland
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Publication number: 20220127574Abstract: The present invention relates to a modified natural killer (NK) cell and its use in personalised medicine. The modified NK cells of the present invention are non-immunogenic, meaning that they are able to be administered to any recipient subject without being rejected by the host immune system (they are “universal”). In a first embodiment the non-immunogenic NK cells are modified to express CD3 to allow a T-cell Receptor (TcR) to be expressed. In a further embodiment the non-immunogenic NK cells are further modified to express a TcR together with the CD3 co-receptor. Co-expression of CD3 with a specific TcR results in the modified NK cells showing antigen-specific cytotoxicity towards target cells. Universal NK cells can thus be targeted against specific antigens, and may thus be used in personalised medicine, particularly in the field of oncology.Type: ApplicationFiled: September 23, 2021Publication date: April 28, 2022Inventors: Sébastien Wälchli, Else Marit Inderberg Suso, Gustav Gaudernack, Gunnar Kvalheim
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Patent number: 11155786Abstract: The present invention relates to a modified natural killer (NK) cell and its use in personalised medicine. The modified NK cells of the present invention are non-immunogenic, meaning that they are able to be administered to any recipient subject without being rejected by the host immune system (they are “universal”). In a first embodiment the non-immunogenic NK cells are modified to express CD3 to allow a T-cell Receptor (TcR) to be expressed. In a further embodiment the non-immunogenic NK cells are further modified to express a TcR together with the CD3 co-receptor. Co-expression of CD3 with a specific TcR results in the modified NK cells showing antigen-specific cytotoxicity towards target cells. Universal NK cells can thus be targeted against specific antigens, and may thus be used in personalised medicine, particularly in the field of oncology.Type: GrantFiled: January 22, 2016Date of Patent: October 26, 2021Assignee: Oslo Universitetssykehus HFInventors: Sébastien Wälchli, Else Marit Inderberg Suso, Gustav Gaudernack, Gunnar Kvalheim
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Publication number: 20200308279Abstract: Provided herein are compositions and methods for immunotherapy. In particular, provided herein are chimeric antigen receptors, cells expressing chimeric antigen receptors, and use of such cells in immunotherapy (e.g., cancer immunotherapy).Type: ApplicationFiled: March 5, 2018Publication date: October 1, 2020Inventors: Sébastien WÄLCHLI, Even WALSENG, Else Marit INDERBERG, Hakan KÖKSAL
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Publication number: 20200121771Abstract: A polypeptide comprising the sequence of SEQ. ID NO. 2, 3, 4, 7 or 8. The polypeptide may have the sequence of an immunogenic fragment thereof comprising at least eight amino acids, wherein the immunogenic fragment is not one of SEQ. ID NOS. 6 or 11 to 16. The polypeptide may have a sequence having at least 80% sequence identity to the aforementioned polypeptide or immunogenic fragment. The polypeptide is less than 100 amino acids in length and does not comprise the sequence of any of SEQ. ID NOS. 10, 46, 56, 57 or 59 to 62 and does not consist of the sequence of SEQ ID NO. 58. The polypeptide is useful in the treatment or prophylaxis of cancer.Type: ApplicationFiled: December 12, 2019Publication date: April 23, 2020Inventors: Gustav Gaudernack, Anne-Marie Rasmussen, Else Marit Inderberg Suso
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Publication number: 20190358263Abstract: The present invention relates to cancer immunotherapy. In particular, provided herein are compositions and methods for improving the efficacy of cell therapies cancer and other diseases.Type: ApplicationFiled: December 7, 2017Publication date: November 28, 2019Inventors: Sebastien Walchli, Else Marit Inderberg, Gunnar Kvalheim, Gustav Gaudernack, Nadia Mensali
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Publication number: 20190336529Abstract: The present invention relates to TCR molecules which recognise neopeptides produced as a result of the cancer-associated “?1A” frameshift mutation in human TGF?RII. The TCR molecules are capable of binding a peptide of SEQ ID NO: 1 when said peptide is presented by a Class I MHC, and comprise an ?-chain domain and a ?-chain domain, each chain domain comprising three CDR sequences, wherein a) CDRs 1, 2 and 3 of the ?-chain domain have the sequences of SEQ ID NOs: 2, 3 and 4 respectively; and b) CDRs 1, 2 and 3 of the ?-chain domain have the sequences of SEQ ID NOs: 5, 6 and 7 respectively, and wherein one or more of said CDR sequences may optionally be modified by substitution, addition or deletion of 1 or 2 amino acids. Nucleic acid molecules encoding such TCRs are provided, as are soluble TCR molecules with these CDR sequences.Type: ApplicationFiled: May 9, 2017Publication date: November 7, 2019Applicant: Oslo Universitetssykehus HFInventors: Else Marit Inderberg, Gustav Gaudernack, Sèbastien Wälchli, Gunnar Kvalheim
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Patent number: 10383928Abstract: A polypeptide comprising the sequence of SEQ. ID NO. 2, 3, 4, 7 or 8. The polypeptide may have the sequence of an immunogenic fragment thereof comprising at least eight amino acids, wherein the immunogenic fragment is not one of SEQ. ID NOS. 6 or 11 to 16. The polypeptide may have a sequence having at least 80% sequence identity to the aforementioned polypeptide or immunogenic fragment. The polypeptide is less than 100 amino acids in length and does not comprise the sequence of any of SEQ. ID NOS. 10, 46, 56, 57 or 59 to 62 and does not consist of the sequence of SEQ ID NO. 58. The polypeptide is useful in the treatment or prophylaxis of cancer.Type: GrantFiled: April 27, 2017Date of Patent: August 20, 2019Assignee: ULTIMOVACS ASInventors: Gustav Gaudernack, Anne-Marie Rasmussen, Else Marit Inderberg Suso
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Publication number: 20190048061Abstract: The present invention relates to nucleic acid molecules encoding chimeric antigen receptors (CARs) against the antigen CD37. The CARs disclosed herein have complementarity-determining regions (CDRs) derived from the potent monoclonal anti-CD37 antibody HH1, and may be used in immunotherapy to target cells expressing CD37. Such immunotherapy has a particular use in the treatment of B-cell cancers. The CARs of the present invention are highly functional in the redirection of immune cells to kill CD37+ cells, and include humanised CARs of particular use in medical therapy. The present invention also includes vectors comprising the above-described nucleic acid molecules, immune effector cells expressing the aforementioned CARs and the use of such immune effector cells in therapy, particularly adoptive transfer therapy, for cancer, including B-cell malignancies.Type: ApplicationFiled: January 6, 2017Publication date: February 14, 2019Inventors: Erlend SMELAND, Sebastien WALCHLI, Gunnar KVALHEIM, Harald HOLTE, June Helen MYKLEBUST, Steinar FUNDERUD, Else Marit INDERBERG
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Publication number: 20180010097Abstract: The present invention relates to a modified natural killer (NK) cell and its use in personalised medicine. The modified NK cells of the present invention are non-immunogenic, meaning that they are able to be administered to any recipient subject without being rejected by the host immune system (they are “universal”). In a first embodiment the non-immunogenic NK cells are modified to express CD3 to allow a T-cell Receptor (TcR) to be expressed. In a further embodiment the non-immunogenic NK cells are further modified to express a TcR together with the CD3 co-receptor. Co-expression of CD3 with a specific TcR results in the modified NK cells showing antigen-specific cytotoxicity towards target cells. Universal NK cells can thus be targeted against specific antigens, and may thus be used in personalised medicine, particularly in the field of oncology.Type: ApplicationFiled: January 22, 2016Publication date: January 11, 2018Inventors: Sébastien WÄLCHLI, Else Marit Inderberg SUSO, Gustav GAUDERNACK, Gunnar KVALHEIM
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Publication number: 20170232087Abstract: A polypeptide comprising the sequence of SEQ. ID NO. 2, 3, 4, 7 or 8. The polypeptide may have the sequence of an immunogenic fragment thereof comprising at least eight amino acids, wherein the immunogenic fragment is not one of SEQ. ID NOS. 6 or 11 to 16. The polypeptide may have a sequence having at least 80% sequence identity to the aforementioned polypeptide or immunogenic fragment. The polypeptide is less than 100 amino acids in length and does not comprise the sequence of any of SEQ. ID NOS. 10, 46, 56, 57 or 59 to 62 and does not consist of the sequence of SEQ ID NO. 58. The polypeptide is useful in the treatment or prophylaxis of cancer.Type: ApplicationFiled: April 27, 2017Publication date: August 17, 2017Inventors: Gustav Gaudernack, Anne-Marie Rasmussen, Else Marit Inderberg Suso
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Publication number: 20170232088Abstract: A polypeptide comprising the sequence of SEQ. ID NO. 2, 3, 4, 7 or 8. The polypeptide may have the sequence of an immunogenic fragment thereof comprising at least eight amino acids, wherein the immunogenic fragment is not one of SEQ. ID NOS. 6 or 11 to 16. The polypeptide may have a sequence having at least 80% sequence identity to the aforementioned polypeptide or immunogenic fragment. The polypeptide is less than 100 amino acids in length and does not comprise the sequence of any of SEQ. ID NOS. 10, 46, 56, 57 or 59 to 62 and does not consist of the sequence of SEQ ID NO. 58. The polypeptide is useful in the treatment or prophylaxis of cancer.Type: ApplicationFiled: April 27, 2017Publication date: August 17, 2017Inventors: Gustav Gaudernack, Anne-Marie Rasmussen, Else Marit Inderberg Suso
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Patent number: 9657068Abstract: A polypeptide comprising the sequence of SEQ. ID NO. 2, 3, 4, 7 or 8. The polypeptide may have the sequence of an immunogenic fragment thereof comprising at least eight amino acids, wherein the immunogenic fragment is not one of SEQ. ID NOS. 6 or 11 to 16. The polypeptide may have a sequence having at least 80% sequence identity to the aforementioned polypeptide or immunogenic fragment. The polypeptide is less than 100 amino acids in length and does not comprise the sequence of any of SEQ. ID NOS. 10, 46, 56, 57 or 59 to 62 and does not consist of the sequence of SEQ ID NO. 58. The polypeptide is useful in the treatment or prophylaxis of cancer.Type: GrantFiled: February 15, 2011Date of Patent: May 23, 2017Assignee: Ultimovacs ASInventors: Gustav Gaudernack, Anne-Marie Rasmussen, Else Marit Inderberg Suso
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Publication number: 20130129760Abstract: A polypeptide comprising the sequence of SEQ. ID NO. 2, 3, 4, 7 or 8. The polypeptide may have the sequence of an immunogenic fragment thereof comprising at least eight amino acids, wherein the immunogenic fragment is not one of SEQ. ID NOS. 6 or 11 to 16. The polypeptide may have a sequence having at least 80% sequence identity to the aforementioned polypeptide or immunogenic fragment. The polypeptide is less than 100 amino acids in length and does not comprise the sequence of any of SEQ. ID NOS. 10, 46, 56, 57 or 59 to 62 and does not consist of the sequence of SEQ ID NO. 58. The polypeptide is useful in the treatment or prophylaxis of cancer.Type: ApplicationFiled: February 15, 2011Publication date: May 23, 2013Inventors: Gustav Gaudernack, Anne-Marie Rasmussen, Else Marit Inderberg Suso