Patents by Inventor Elsie May Williams

Elsie May Williams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacterial nitroreductase enzymes and methods relating thereto
    Patent number: 10357577
    Abstract: The invention relates generally to bacterial nitroreductase enzymes and methods of use thereof: more particularly, although not exclusively, the enzymes have use in non-invasive imaging techniques, monitoring of therapeutic cell populations and gene-directed enzyme prodrug therapy. The invention also relates to the use of bacterial nitroreductase enzymes in radioimaging and/or ablation of biological agents and to compositions of use in such methods.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: July 23, 2019
    Assignees: AUCKLAND UNISERVICES LIMITED, VICTORIA LINK LIMITED
    Inventors: Christopher Paul Guise, David Francis Ackerley, Amir Ashoorzadeh, Janine Naomi Copp, Jack Urquhart Flanagan, Alexandra Marie Mowday, Adam Vorn Patterson, Gareth Adrian Prosser, Jeffrey Bruce Smaill, Sophie Phillipa Syddall, Elsie May Williams
  • Novel Prodrugs And Methods Of Use Thereof
    Publication number: 20190153002
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Application
    Filed: January 18, 2019
    Publication date: May 23, 2019
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • Prodrugs and methods of use thereof
    Patent number: 10202408
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: February 12, 2019
    Assignee: Health Innovation Ventures B.V.
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • Novel Prodrugs And Methods Of Use Thereof
    Publication number: 20180148463
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Application
    Filed: January 22, 2018
    Publication date: May 31, 2018
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • Prodrugs and methods of use thereof
    Patent number: 9873710
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: January 23, 2018
    Assignee: Health Innovation Ventures B.V.
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • Novel Prodrugs And Methods Of Use Thereof
    Publication number: 20170044191
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Application
    Filed: October 31, 2016
    Publication date: February 16, 2017
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • Prodrugs and methods of use thereof
    Patent number: 9505791
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: November 29, 2016
    Assignee: Health Innovation Ventures B.V.
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • Novel Prodrugs And Methods Of Use Thereof
    Publication number: 20150299230
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Application
    Filed: August 22, 2013
    Publication date: October 22, 2015
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • Compounds And Methods For Selective Imaging And/Or Ablation
    Publication number: 20150010474
    Abstract: The invention relates generally to compounds and methods for imaging and/or selective ablation of nitroreductase-expressing cells and/or biological agents. More particularly, although not exclusively, the invention provides compounds that are selectively metabolised by bacterial nitroreductases and are substantially insensitive to metabolism under oxic or hypoxic conditions by human nitroreductase enzymes.
    Type: Application
    Filed: December 21, 2012
    Publication date: January 8, 2015
    Inventors: Robert Forbes Anderson, Jeffery Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, David Francis Ackerley, Janine Naomi Copp, Alexandra Marie Mowday, Elsie May Williams, Christopher Paul Guise, Cameron Koch, Alex Kachur, William R. Dolbier, JR.
  • BACTERIAL NITROREDUCTASE ENZYMES AND METHODS RELATING THERETO
    Publication number: 20130295011
    Abstract: The invention relates generally to bacterial nitroreductase enzymes and methods of use thereof: More particularly, although not exclusively, said enzymes have use in non-invasive imaging techniques, monitoring of therapeutic cell populations and gene-directed enzyme prodrug therapy. The invention also relates to the use of bacterial nitroreductase enzymes in radioimaging and/or ablation of biological agents and to compositions of use in such methods.
    Type: Application
    Filed: July 18, 2011
    Publication date: November 7, 2013
    Applicants: VICTORIA LINK LIMITED, AUCKLAND UNISERVICES LIMITED
    Inventors: Christopher Paul Guise, David Francis Ackerley, Amir Ashoorzadeh, Janine Naomi Copp, Jack Urquhart Flanagan, Alexandra Marie Mowday, Adam Vorn Patterson, Gareth Adrian Prosser, Jeffrey Bruce Smaill, Sophie Phillipa Syddall, Elsie May Williams