Patents by Inventor Elsio WUNDER

Elsio WUNDER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VACCINE AGAINST LEPTOSPIROSIS
    Publication number: 20250152689
    Abstract: The disclosure provides a composition comprising an effective amount of a plurality of leptospiral proteins, or immunogenic fragments thereof. The disclosure further provides a method of generating an immune response against leptospirosis using a composition comprising the plurality of leptospiral proteins, or immunogenic fragments thereof, and an adjuvant.
    Type: Application
    Filed: January 24, 2023
    Publication date: May 15, 2025
    Inventors: Elsio Wunder, Albert Ko
  • Compositions and methods of preparing
    Patent number: 10603370
    Abstract: The present invention includes compositions and methods of preparing flagellar-coiling protein 1 (Fcp1)-deficient Leptospira bacterium. In one aspect, the invention includes an isolated, flagellar-coiling protein 1 (Fcp1)-deficient Leptospira bacterium. Another aspect includes a composition comprising a flagellar-coiling protein 1 (Fcp1) deficient Leptospira bacterium. Yet another aspect includes a method of producing a motility-deficient Leptospira bacterium comprising inhibiting expression of a wild-type flagellar-coiling protein 1 (Fcp1) gene. Methods of stimulating an immune response and reducing or treating an infectious disease caused by one or more Leptospira bacteria in a subject in need thereof comprising administering a composition comprising an effective amount of flagellar-coiling protein 1 (Fcp1) deficient Leptospira bacteria to the subject are also included.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: March 31, 2020
    Assignee: Yale University
    Inventors: Albert Ko, Elsio Wunder
  • COMPOSITIONS AND METHODS OF PREPARING LEPTOSPIRA
    Publication number: 20190105382
    Abstract: The present invention includes compositions and methods of preparing flagellar-coiling protein 1 (Fcp1)-deficient Leptospira bacterium. In one aspect, the invention includes an isolated, flagellar-coiling protein 1 (Fcp1)-deficient Leptospira bacterium. Another aspect includes a composition comprising a flagellar-coiling protein 1 (Fcp1) deficient Leptospira bacterium. Yet another aspect includes a method of producing a motility-deficient Leptospira bacterium comprising inhibiting expression of a wild-type flagellar-coiling protein 1 (Fcp1) gene. Methods of stimulating an immune response and reducing or treating an infectious disease caused by one or more Leptospira bacteria in a subject in need thereof comprising administering a composition comprising an effective amount of flagellar-coiling protein 1 (Fcp1) deficient Leptospira bacteria to the subject are also included.
    Type: Application
    Filed: October 22, 2018
    Publication date: April 11, 2019
    Inventors: Albert KO, Elsio WUNDER
  • Compositions and methods of preparing Leptospira
    Patent number: 10143735
    Abstract: The present invention includes compositions and methods of preparing flagellar-coiling protein 1 (Fcp1)-deficient Leptospira bacterium. In one aspect, the invention includes an isolated, flagellar-coiling protein 1 (Fcp1)-deficient Leptospira bacterium. Another aspect includes a composition comprising a flagellar-coiling protein 1 (Fcp1) deficient Leptospira bacterium. Yet another aspect includes a method of producing a motility-deficient Leptospira bacterium comprising inhibiting expression of a wild-type flagellar-coiling protein 1 (Fcp1) gene. Methods of stimulating an immune response and reducing or treating an infectious disease caused by one or more Leptospira bacteria in a subject in need thereof comprising administering a composition comprising an effective amount of flagellar-coiling protein 1 (Fcp1) deficient Leptospira bacteria to the subject are also included.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: December 4, 2018
    Assignee: Yale University
    Inventors: Albert Ko, Elsio Wunder
  • COMPOSITIONS AND METHODS OF PREPARING LEPTOSPIRA
    Publication number: 20170014500
    Abstract: The present invention includes compositions and methods of preparing flagellar-coiling protein 1 (Fcp1)-deficient Leptospira bacterium. In one aspect, the invention includes an isolated, flagellar-coiling protein 1 (Fcp1)-deficient Leptospira bacterium. Another aspect includes a composition comprising a flagellar-coiling protein 1 (Fcp1) deficient Leptospira bacterium. Yet another aspect includes a method of producing a motility-deficient Leptospira bacterium comprising inhibiting expression of a wild-type flagellar-coiling protein 1 (Fcp1) gene. Methods of stimulating an immune response and reducing or treating an infectious disease caused by one or more Leptospira bacteria in a subject in need thereof comprising administering a composition comprising an effective amount of flagellar-coiling protein 1 (Fcp1) deficient Leptospira bacteria to the subject are also included.
    Type: Application
    Filed: March 11, 2015
    Publication date: January 19, 2017
    Inventors: Albert KO, Elsio WUNDER